Antibody repertoire development in fetal and neonatal piglets. XI. The relationship of variable heavy chain gene usage and the genomic organization of the variable heavy chain locus

Journal of Immunology

Volumn 184, Issue 7, 2010, Pages 3734-3742

  Eguchi Ogawa, Tomoko ^a   Wertz, Nancy ^b   Sun, Xiu Zhu ^b   Puimi, Francois ^c   Uenishi, Hirohide ^a   Wells, Kevin ^d   Chardon, Patrick ^c   Tobin, Gregory J ^e   Butler, John E ^b  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^b UNIVERSITY OF IOWA   (United States)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

^d UNIVERSITY OF MISSOURI   (United States)

^e Biological Mimetics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G3; IMMUNOGLOBULIN HEAVY CHAIN;

ANTIBODY PRODUCTION; ARTICLE; CHROMOSOME 7; FETUS; GENE DUPLICATION; GENE LOCUS; GENE MAPPING; GENETIC ORGANIZATION; GENETIC VARIABILITY; IMMUNOGLOBULIN VARIABLE REGION; MUTATION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGLET; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; BACTERIAL ARTIFICIAL CHROMOSOME; CHROMOSOME MAP; GENETICS; HUMAN; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOLOGY; MOLECULAR GENETICS; PHYLOGENY; SEQUENCE HOMOLOGY; SWINE;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, ARTIFICIAL, BACTERIAL; FETUS; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; SWINE;

EID: 77951627839     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903616     Document Type: Article

References (59)

1. Butler, J. E. 2006. Preface: why I agreed to do this. Dev. Comp. Immunol. 30: 1-17.
2. Schroeder, H. W., Jr. 2006. Similarity and divergence in the development and expression of the mouse and human antibody repertoires. Dev. Comp. Immunol. 30: 119-135.
3. Das, S., M. Nozawa, J. Klein, and M. Nei. 2008. Evolutionary dynamics of the immunoglobulin heavy chain variable region genes in vertebrates. Immunogenetics 60: 47-55.
4. Lefranc, M.-P., and G. Lefranc. 2001. The Immunoglobulin Facts Book. Academic Press, New York.
5. Brodeur, P. H., and R. Riblet. 1984. The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14: 922-930.
6. Schroeder, H. W., Jr., J. L. Hillson, and R. M. Perlmutter. 1990. Structure and evolution of mammalian VH families. Int. Immunol. 2: 41-50.
7. Marchalonis, J. J., M. K. Adelman, S. F. Schluter, and P. A. Ramsland. 2006. The antibody repertoire in evolution: chance, selection, and continuity. Dev. Comp. Immunol. 30: 223-247.
8. HIII. J. Immunol. 153: 5618-5627.
9. Butler, J. E., P. Weber, and N. Wertz. 2006. Antibody repertoire development in fetal and neonatal piglets. XIII. Hybrid VH genes and the preimmune repertoire revisited. J. Immunol. 177: 5459-5470.
10. Meselson, M. S., and C. M. Radding. 1975. A general model for genetic recombination. Proc. Natl. Acad. Sci. USA 72: 358-361.
11. Szostak, J. W., T. L. Orr-Weaver, R. J. Rothstein, and F. W. Stahl. 1983. The double-strand-break repair model for recombination. Cell 33: 25-35.
12. Yancopoulos, G. D., S. V. Desiderio, M. Paskind, J. F. Kearney, D. Baltimore, and F. W. Alt. 1984. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 311: 727-733.
13. Perlmutter, R. M., J. F. Kearney, S. P. Chang, and L. E. Hood. 1985. Developmentally controlled expression of immunoglobulin VH genes. Science 227: 1597-1601.
14. Malynn, B. A., G. D. Yancopoulos, J. E. Barth, C. A. Bona, and F. W. Alt. 1990. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J. Exp. Med. 171: 843-859.
15. Freitas, A. A., A.-C. Viale, A. Sundblad, C. Heusser, and A. A. Coutinho. 1991. Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires. Proc. Natl. Acad. Sci. USA 88: 5640-5644.
16. Varade, W. S., E. Marin, A. M. Kittelberger, and R. A. Insel. 1993. Use of the most JH-proximal human Ig H chain V region gene, VH6, in the expressed immune repertoire. J. Immunol. 150: 4985-4995.
17. Cuisinier, A. M., V. Guigou, L. Boubli, M. Fougereau, and C. Tonnelle. 1989. Preferential expression of VH5 and VH6 immunoglobulin genes in early human B-cell ontogeny. Scand. J. Immunol. 30: 493-497.
18. Knight, K. L., and R. S. Becker. 1990. Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity. Cell 60: 963-970. (Pubitemid 20103878)
19. Becker, R. S., and K. L. Knight. 1990. Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits. Cell 63: 987-997.
20. Kraj, P., S. P. Rao, A. M. Glas, R. R. Hardy, E. C. Milner, and L. E. Silberstein. 1997. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J. Immunol. 158: 5824-5832. (Pubitemid 127483989)
21. Ollo, R., J.-L. Sikorav, and F. Rougeon. 1983. Structural relationships among mouse and human immunoglobulin VH genes in the subgroup III. Nucleic Acids Res. 11: 7887-7897.
22. Adderson, E. E., P. G. Shackelford, A. Quinn, and W. L. Carroll. 1991. Restricted Ig H chain V gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide. J. Immunol. 147: 1667-1674.
23. Fulton, R. J., M. H. Nahm, and J. M. Davie. 1983. Monoclonal antibodies to streptococcal group A carbohydrate. II. The VK1GAC light chain is preferentially associated with serum IgG3. J. Immunol. 131: 1326-1331.
24. Oliver, A. M., F. Martin, G. L. Gartland, R. H. Carter, and J. F. Kearney. 1997. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27: 2366-2374.
25. Milili, M., M. Fougereau, P. Guglielmi, and C. Schiff. 1991. Early occurrence of immunoglobulin isotype switching in human fetal liver. Mol. Immunol. 28: 753-761.
26. Fagarasan, S., and T. Honjo. 2000. T-independent immune responses: new aspects of B cell biology. Science 290: 89-92.
27. Manis, J. P., M. Tian, and F. W. Alt. 2002. Mechanism and control of classswitch recombination. Trends Immunol. 23: 31-39.
28. Butler, J. E., and N. Wertz. 2006. Antibody repertoire development in fetal and neonatal piglets. XVII. IgG subclass transcription revisited with emphasis on new IgG3. J. Immunol. 177: 5480-5489.
29. Reynaud, C. A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80: 115-125.
30. Zhang, J., F. W. Alt, and T. Honjo. 1995. Regulation of class switch recombination of the immunoglobulin heavy chain genes. In Immunoglobulin Genes. T. Honjo, and F. W. Alt, eds. Academic Press, New York. p. 235-265.
31. Honjo, T., and F. Matsuda. 1995. Immunoglobulin heavy chain locus of mouse and humans. In Immunoglobulin Genes. T. Honjo, and F. W. Alt, eds. Academic Press, New York. p. 145-171.
32. Brambell, F. W. R. 1970. The Transmission of Passive Immunity from Mother to Young. North-Holland Publishers, Amsterdam.
33. Butler, J. E. 1974. Immunoglobulins of the mammary secretions. In Lactation, A Comprehensive Treatise, Vol. III. B. L. Larson, and V. Smith, eds. Academic Press, New York, p. 217-255.
34. Butler, J. E. 1998. Immunoglobulins and immune cells in animal milks. In Mucosal Immunology, P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee, and J. Bienenstock, eds. Academic Press, New York, p. 1531-1554.
35. Yamaguchi, N., S. Shimizu, A. Hara, and T. Saito. 1983. The effect of maternal antigenic stimulation upon the active immune responsiveness of their offspring. Immunology 50: 229-238. (Pubitemid 13004250)
36. Wikler, M., C. Demeur, G. Dewasme, and J. Urbain. 1980. Immunoregulatory role of maternal idiotypes. Ontogeny of immune networks. J. Exp. Med. 152: 1024-1035.
37. Butler, J. E., and M. Sinkora. 2007. The isolator piglet: a model for studying the development of adaptive immunity. Immunol. Res. 39: 33-51.
38. Butler, J. E., J. Sun, and P. Navarro. 1996. The swine Ig heavy chain locus has a single JH and no identifiable IgD. Int. Immunol. 8: 1897-1904.
39. Sun, J., C. Hayward, R. Shinde, R. Christenson, S. P. Ford, and J. E. Butler. 1998. Antibody repertoire development in fetal and neonatal piglets. I. Four VH genes account for 80 percent of VH usage during 84 days of fetal life. J. Immunol. 161: 5070-5078.
40. Sun, J., and J. E. Butler. 1996. Molecular characteristics of VDJ transcripts from a newborn piglet. Immunology 88: 331-339. (Pubitemid 26225154)
41. Butler, J. E., N. Wertz, N. Deschacht, and I. Kacskovics. 2009. Porcine IgG: structure, genetics, and evolution. Immunogenetics 61: 209-230.
42. Rogel-Galliard, C., N. Bourgeaux, A. Billault, M. Vaiman, and P. Chardon. 1999. Construction of a swine BAC library: application to the characterization and mapping of porcine type C endoviral elements. Cytogenet. Cell Genet. 85: 205-211.
43. Ewing, B., and P. Green. 1998. Base-calling of automated sequencer traces using phred. II. Error probabilities. Genome Res. 8: 186-194.
44. Ewing, B., L. Hillier, M. C. Wendl, and P. Green. 1998. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res. 8: 175-185.
45. Tatusova, T. A., and T. L. Madden. 1999. BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences. FEMS Microbiol. Lett. 174: 247-250.
46. Jurka, J. 2000. Repbase update: a database and an electronic journal of repetitive elements. Trends Genet. 16: 418-420.
47. Schwartz, S., Z. Zhang, K. A. Frazer, A. Smit, C. Riemer, J. Bouck, R. Gibbs, R. Hardison, and W. Miller. 2000. PipMaker - a web server for aligning two genomic DNA sequences. Genome Res. 10: 577-586. (Pubitemid 30259089)
48. Thompson, J. D., T. J. Gibson, F. Plewniak, F. Jeanmougin, and D. G. Higgins. 1997. The CLUSTAL-X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25: 4876-4882.
49. Sun, J., and J. E. Butler. 1997. Sequence analysis of pig switch μ, C μ, and C μ m. Immunogenetics 46: 452-460.
50. Li, W. H., T. Gojobori, and M. Nei. 1981. Pseudogenes as a paradigm of neutral evolution. Nature 292: 237-239.
51. Zhao, Y., Q. Pan-Hammarström, I. Kacskovics, and L. Hammarström. 2003. The porcine Ig delta gene: unique chimeric splicing of the first constant region domain in its heavy chain transcripts. J. Immunol. 171: 1312-1318. (Pubitemid 36900062)
52. Sasso, E. H., K. Willems van Dijk, A. Bull, S. M. van der Maarel, and E. C. B. Milner. 1992. VH genes in tandem array comprise a repeated germline motif. J. Immunol. 149: 1230-1236.
53. Navarro, P., R. K. Christenson, G. Ekhardt, B. Bosworth, J. K. Lunney, M. Rothschild, J. Lemke, and J. E. Butler. 2000. Genetic differences in the frequency of the hinge variants of porcine IgA is breed dependent. Vet. Immunol. Immunopathol. 73: 287-295.
54. Sinkora, M., and J. E. Butler. 2009. The ontogeny of the porcine immune system. Dev. Comp. Immunol. 33: 273-283.
55. Melchers, F. 1995. The role of B cell and pre-B cell receptors in development and growth control of the B-lymphocyte cell lineage. In Immunoglobulin Genes. T. Honjo, and F. W. Alt, eds. Academic Press, New York, p. 33-56.
56. Pospisil, R., G. O. Young-Cooper, and R. G. Mage. 1995. Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits. Proc. Natl. Acad. Sci. USA 92: 6961-6965.
57. Padlan, E. A. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31: 169-217.
58. Xu, J. L., and M. M. Davis. 2000. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 13: 37-45.
59. Butler, J. E., P. Weber, M. Sinkora, J. Sun, S. J. Ford, and R. Christenson. 2000. Antibody repertoire development in fetal and neonatal piglets. II. Characterization of heavy chain complimentarity-determining region 3 diversity in the developing fetus. J. Immunol. 165: 6999-7011.