Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice

Journal of Hepatology

Volumn 52, Issue 5, 2010, Pages 705-711

  McNeilly, Alison D ^a   Macfarlane, David P ^a   O'Flaherty, Emmett ^a   Livingstone, Dawn E ^a   Mitić, Tijana ^a   McConnell, Kirsty M ^a   McKenzie, Scott M ^b   Davies, Eleanor ^b   Reynolds, Rebecca M ^a   Thiesson, Helle C ^c   Skøtt, Ole ^c   Walker, Brian R ^a   Andrew, Ruth ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

5 reductase; Adrenal; Bile acid; Glucocorticoid; Jaundice

Indexed keywords

3ALPHA,11BETA,17ALPHA,21 TETRAHYDROXY 5BETA PREGNAN 20 ONE; 3ALPHA,5BETA TETRAHYDROCORTICOSTERONE; BILE ACID; CHENODEOXYCHOLIC ACID; CORTICOSTERONE DERIVATIVE; GLUCOCORTICOID; STEROID 5BETA REDUCTASE; UNCLASSIFIED DRUG;

ADRENAL INSUFFICIENCY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; CELL STRAIN HEPG2; CHOLELITHIASIS; CHOLESTASIS; CLINICAL ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; DIET SUPPLEMENTATION; FEMALE; HEPATOMA CELL; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CYTOSOL; MALE; NONHUMAN; OBSTRUCTIVE JAUNDICE; PRIORITY JOURNAL; PROMOTER REGION; RAT; URINE LEVEL;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BASE SEQUENCE; BILE ACIDS AND SALTS; BILE DUCTS; CYTOSOL; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; JAUNDICE, OBSTRUCTIVE; KINETICS; LIGATION; LIVER; MALE; PITUITARY-ADRENAL SYSTEM; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; TETRAHYDROCORTISOL; TRANSCRIPTION, GENETIC;

EID: 77951621825     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.10.037     Document Type: Article

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