LOCF Approach to Handling Missing Data Overestimates the Pain Score Improvement of Drop-Outs

Journal of Pain

Volumn 11, Issue 5, 2010, Pages 500-501

  O'Connor, Alec B ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HARKOSERIDE; PLACEBO;

BASELINE OBSERVATION CARRIED FORWARD; CHRONIC PAIN; CLINICAL TRIAL; DIABETIC NEUROPATHY; DRUG EFFICACY; DRUG WITHDRAWAL; HUMAN; LAST OBSERVATION CARRIED FORWARD; LETTER; NEUROPATHIC PAIN; PAIN ASSESSMENT; SCORING SYSTEM; STATISTICAL PARAMETERS; UNSPECIFIED SIDE EFFECT;

ACETAMIDES; ANALGESICS; CLINICAL TRIALS AS TOPIC; DATA INTERPRETATION, STATISTICAL; DIABETIC NEUROPATHIES; HUMANS; MODELS, STATISTICAL; NEURALGIA; PAIN MEASUREMENT; PATIENT DROPOUTS; TREATMENT OUTCOME; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 77951620503     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2010.01.001     Document Type: Letter

References (4)

1. O'Connor A.B. The need for improved access to FDA reviews. JAMA 302 (2009) 191-193
2. Shaibani A., Fares S., Selam J.L., Arslanian A., Simpson J., Sen D., and Bongardt S. Lacosamide in painful diabetic neuropathy: An 18-week double-blind placebo-controlled trial. J Pain 10 (2009) 818-828
3. US FDA. Approval package for: Application number 21-446 medical review(s). http://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/021446_LyricaTOC.cfm Accessed September 7, 2009
4. Wymer J.P., Simpson J., Sen D., and Bongardt S. Efficacy and safety of lacosamide in diabetic neuropathic pain: An 18-week double-blind placebo-controlled trial of fixed-dose regimens. Clin J Pain 25 (2009) 376-385