Evaluation of ventricular arrhythmias in early clinical pharmacology trials and potential consequences for later development

American Heart Journal

Volumn 159, Issue 5, 2010, Pages 716-729

  Min, Sherene S ^a   Turner, J Rick ^b   Nada, Adel ^c   DiMino, Tara L ^a   Hynie, Ivo ^d   Kleiman, Robert ^e   Kowey, Peter ^f   Krucoff, Mitchell W ^g   Mason, Jay W ^h   Phipps, Alex ⁱ   Newton Cheh, Christopher ^j   Pordy, Robert ^k   Strnadova, Colette ^d   Targum, Shari ^l   Uhl, Kathleen ^l   Finkle, John ^a  

^a GLAXOSMITHKLINE   (United States)

^b IQVIA   (United States)

^c ABBOTT LABORATORIES   (United States)

^d HEALTH CANADA   (Canada)

^e ERT   (United States)

^f LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h UNIVERSITY OF UTAH   (United States)

ⁱ PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k HOFFMANN LA ROCHE INC   (United States)

^l CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT;

CLINICAL EVALUATION; CLINICAL RESEARCH; ELECTROCARDIOGRAPHY MONITORING; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HEMODYNAMIC MONITORING; HOLTER MONITORING; HUMAN; NONHUMAN; PATIENT SAFETY; PREVALENCE; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL; RESEARCH SUBJECT; REVIEW; SIDE EFFECT; SUPRAVENTRICULAR TACHYCARDIA; TELEMETRY;

ARRHYTHMIAS, CARDIAC; CLINICAL TRIALS, PHASE I AS TOPIC; COST-BENEFIT ANALYSIS; DRUG DISCOVERY; ELECTROCARDIOGRAPHY; HUMANS; MONITORING, PHYSIOLOGIC; PATIENT SELECTION; PREVALENCE; RISK ASSESSMENT; TELEMETRY;

EID: 77951612629     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2010.02.004     Document Type: Review

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