Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders

Phytotherapy Research

Volumn 24, Issue 4, 2010, Pages 553-558

  Gilani, Syed Naeemuddin ^a,b   Khan, Arif Ullah ^a,c   Gilani, Anwarul Hassan ^a  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b Industrial Research Laboratories   (Pakistan)

^c KOHAT UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Pakistan)

Author keywords

Antispasmodic; Bronchodilator; Ca++ channel blocker; Cardio depressant; Vasodilator; Zanthoxylum armatum

Indexed keywords

ANTIDIARRHEAL AGENT; CALCIUM ION; CARBACHOL; CASTOR OIL; LOPERAMIDE; PHENYLEPHRINE; PLANT EXTRACT; POTASSIUM ION; UNCLASSIFIED DRUG; VERAPAMIL; ZANTHOXYLUM ARMATUM EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG ACTIVITY; ENTEROPATHY; FEMALE; GUINEA PIG; HEART ATRIUM; HEART ATRIUM CONTRACTION; JEJUNUM; MALE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; RABBIT; RESPIRATORY TRACT DISEASE; SPASMOLYSIS; TRACHEA; VASCULAR RING; VASODILATATION; ZANTHOXYLUM; ZANTHOXYLUM ARMATUM;

ACUTE TOXICITY TESTS; ANIMALS; ANTIDIARRHEALS; AORTA; BRONCHODILATOR AGENTS; CASTOR OIL; CATHARTICS; DIARRHEA; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HEART ATRIA; JEJUNUM; MICE; PARASYMPATHOLYTICS; PHYTOTHERAPY; PLANT EXTRACTS; RABBITS; TRACHEA; VASODILATOR AGENTS; ZANTHOXYLUM;

CAVIA; MUS; ORYCTOLAGUS CUNICULUS; RUTACEAE; ZANTHOXYLUM ARMATUM;

EID: 77951605332     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2979     Document Type: Article

References (31)

1. Baquar SR. 1989. Medicinal and poisonous plants of Pakistan. Printas: Karachi; 478.
2. Bolton TB. 1979. Mechanism of action of transmitter and other substances on smooth muscles. Physiol Rev 59: 606-718.
3. Brading AF. 1981. How do drugs initiate contractions in smooth muscles. Trends Pharmacol Sci 2: 261-265.
4. Croci T, Landi M, Elmonds-Alt X, Le Fur G, Maffrand JP, Manara L. 1997. Role of tachykinins in castor oil-induced diarrhea in rats. Br J Pharmacol 121: 375-380. (Pubitemid 27226287)
5. nd edn. CRC Press: Boca Raton; 786-787.
6. Edeoga HO, Okwu DE, Mbaebie BO. 2005. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 4: 685-688. (Pubitemid 41032246)
7. Epstein M. 1992. Calcium antagonists in the management of hypertension. In Calcium Antagonists in Clinical Medicine, Epstein M (ed.). Hanley and Belfus: Philadelphia; 213-230.
8. Fleckenstein A. 1977. Specific pharmacology of calcium in myocardium, cardiac pacemakers and vascular smooth muscle. Rev Pharmacol Toxicol 17: 149-166.
9. Ghayur MN, Gilani AH. 2005. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J Cardiovasc Pharmacol 45: 74-80. (Pubitemid 40039759)
10. ++ channel blocking activity of Artemesia scoparia extract. Phytother Res 8: 161-165.
11. Gilani AH, Shah AJ, Ghayur MN, Majeed K. 2005a. Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sci 76: 3089-3105. (Pubitemid 40585710)
12. Gilani AH, Ghayur MN, Khalid A, Zaheer-ul-Haq Q, Choudhary MI, Atta-ur-Rahman 2005b. Presence of antispasmodic, antidiarrhoeal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna. Planta Med 71: 1-6.
13. Gilani AH, Bashir S, Khan A. 2007. Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders. J Ethnopharmacol 114: 393-399. (Pubitemid 350026217)
14. Godfraind T, Miller R, Wibo M. 1986. Calcium antagonism and calcium entry blockade. Pharmacol Rev 38: 321-416.
15. 1- adrenergic receptor subtypes, molecular structure, function and signalling. Cir Res 78: 737-749.
16. +2 in the contractility of rabbit small intestine in vitro. J Physiol Pharmacol 55: 639-650.
17. Kapoor LD. 1990. Handbook of Ayurvedic medicinal plants. CRC Press: Boca Raton; 339-340.
18. Khan A, Gilani AH. 2008. Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect. J Food Drug Anal 16: 6-14.
19. Kokate SD, Venkatachalam SR, Hassarajani SA. 2001. Zanthoxylum armatum extract as mosquito larvicide. Proc Nat Acad Sci Allahbad 71B: 229-232.
20. Kumar S, Muller K. 1999. Inhibition of Keratinocyte growth by different nepalese Zanthoxylum species. Phytother Res 13: 214-217. (Pubitemid 29229449)
21. Mathewson HS. 1985. Anti-asthmatic properties of calcium antagonists. Respir Care 30: 779-781.
22. Mehta MB, Kharya MD, Srivastava R, Verma KC. 1981. Antimicrobial and anthelmintic activities of the essential oil of Zanthoxylum alatum Roxb. Ind Perfum 25: 19-21.
23. Nadkarni KM. 1976. Indian Materia Medica, 3rd edn. Popular Prakashan: Bombay; 1302.
24. National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press: Washington; 1-7.
25. Revuelta MP, Cantabrana B, Hidalgo A. 1997. Depolarizationdependent effect of flavonoids in rat uterine smooth muscle contraction elicited by CaCl2. Gen Pharmacol 29: 847-857. (Pubitemid 27475177)
26. Reynolds IJ, Gould RJ, Snyder SH. 1984. Loperamide: blockade of calcium channels as a mechanism for antidiarrhoeal effects. J Pharmacol Exp Ther 231: 628-632.
27. Shinwari ZK, Khan AA, Nakaike T. 2003. Medicinal and Other Useful Plants of District Swat Pakistan. Al-Aziz Communications: Peshawar; 107.
28. Tiwary M, Naika SN, Tewaryb DK, Mittalc PK, Yadav S. 2007. Chemical composition and larvicidal activities of the essential oil of Zanthoxylum armatum DC. (Rutaceae) against three mosquito vectors. J Vect Borne Dis 44: 198-204. (Pubitemid 47353759)
29. Triggle DJ. 1992. Drugs affecting calcium-regulation and actions. In Text Book of Pharmacology, Smith GM, Reynard AM (eds). W. B. Saunders Co: Philadelphia; 453-479.
30. Usmanghani K, Saeed A, Alam MT. 1997. Indusyunic Medicine, University of Karachi Press: Karachi; 450-451.
31. Williamson EM, Okpako DT, Evans FJ. 1998. Selection, preparation and pharmacological evaluation of plant material. John Wiley & Sons: Chichester; 15-23.