Aspirin dosing for the prevention and treatment of ischemic stroke: An indication-specific review of the literature

Annals of Pharmacotherapy

Volumn 44, Issue 5, 2010, Pages 851-862

  Ansara, Alexander J ^a,b   Nisly, Sarah A ^a,b   Arif, Sally A ^c,d   Koehler, Julia M ^a,b   Nordmeyer, Sarah T ^e  

^a METHODIST HOSPITAL   (United States)

^b BUTLER UNIVERSITY   (United States)

^c James J Peters Veterans Affairs Medical Center   (United States)

^d LONG ISLAND UNIVERSITY   (United States)

^e UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

Author keywords

Acetylsalicylic acid; Antiplatelet; Aspirin; Atrial fibrillation; Carotid endarterectomy; Ischemic stroke; Post myocardial infarction; Prevention

Indexed keywords

ACETYLSALICYLIC ACID; ANTIVITAMIN K; CLOPIDOGREL; DIPYRIDAMOLE; HEPARIN; PLACEBO; SULFINPYRAZONE; WARFARIN;

ATHEROSCLEROSIS; CAROTID ARTERY DISEASE; CAROTID ENDARTERECTOMY; CEREBROVASCULAR ACCIDENT; CLINICAL PRACTICE; CLINICAL TRIAL; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG WITHDRAWAL; GASTROINTESTINAL HEMORRHAGE; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HIGH RISK POPULATION; HUMAN; MONOTHERAPY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; TRANSIENT ISCHEMIC ATTACK;

ASPIRIN; ATHEROSCLEROSIS; CAROTID ARTERY DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; ISCHEMIA; MYOCARDIAL INFARCTION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STROKE; THROMBOXANE A2;

EID: 77951579916     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M346     Document Type: Review

References (68)

1. American Heart Association. Heart disease and stroke statistics - 2010 update. Circulation 2010;121:e1-e170. DOI 10.1161/Circulationaha.109.19266
2. Samsa GP, Matchar DB, Goldstein L, et al. Utilities for major stroke: results from a survey of preferences among persons at increased risk for stroke. Am Heart J 1998;136:703-713 (Pubitemid 28483514)
3. Alarcon M, Palomo I, Toro C. The role of platelets in the pathophysiology of atherosclerosis. Mol Med Rep 2008;1:179-184
4. Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007;357:2482-2494
5. Lange R, Hillis L. Antiplatelet therapy for ischemic heart disease. N Engl J Med 2004;350:277.
6. Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982;69:1366-1372
7. Patrono C, Ciabottoni G, Patriguani P, et al. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation 1985;72:1177-1184
8. Patrono C, Baigent C, Hirsh J, Roth G. Antiplatelet drugs. Chest 2008;133(suppl):199S-233S. DOI 10.1378/chest.08-0672
9. Majerus P. Arachidonate metabolism in vascular disorders. J Clin Invest 1983;72:1521-1525
10. 2 synthase. Nat Struct Biol 1995;2:637-643
11. Peto R, Gray R, Collins R, et al. Randomised trial of prophylactic daily aspirin in British male doctors. BMJ 1988;296:313-316
12. Steering Committee of the Physicians' Health Study Group. Final report of the aspirin component of the ongoing physicians' health study. N Engl J Med 1989;321:129-135
13. Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the hypertension optimal treatment randomised trial. Lancet 1998;351:1755-1762 DOI 10.1016/S0140-6736(98)04311-6 (Pubitemid 28269185)
14. Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001;357:89-95. DOI 10.1016/S0140-6736(00)03539-X
15. The Medical Research Council's General Practice Research Framework. Thrombosis prevention trial: randomised trial of low-intensity oral anti-coagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. Lancet 1998;351:233-241 DOI 10.1016/S0140-6736(97)11475-1
16. Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005;352:1293-1304
17. Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association stroke council. Stroke 2006;37:1583-1633 DOI 10.1161/01.STR. 0000223048.70103.F1
18. Fraker TD, Fihn SD, Gibbons RJ, et al. 2007 Chronic Angina Focused Update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina. Circulation 2007;116;2762-2772 DOI 10.1161/CIRCULATIONAHA.107. 187930)
19. CAST (Chinese Acute Stroke Trial) Collaborative Group. Randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischemic stroke. Lancet 1997;349:1641-1649 DOI 10.1016/S0140-6736(97)04010-5
20. Libman RB, Sacco RL, Shi T, et al. Neurologic improvement in pure motor hemiparesis: implications for clinical trials. Neurology 1992;42: 1713-1716
21. International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 1997;349:1569-1581 DOI 10.1016/S0140-6736(97)04011-7
22. Albers GW, Amarenco P, Easton JD, et al. Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 2008;133(6 suppl):630S-69S. DOI 10.1378/chest.08-0720
23. Adams HP, Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke. Circulation 2007;115;e478-534. DOI 10.1161/CIRCULATIONAHA.107.181486
24. Fields WS, Lemak NA, Frankowski RF, et al. Controlled trial of aspirin in cerebral ischemia. Stroke 1977;8:301-314
25. Canadian Co-operative Study Group. A randomized trial of aspirin and sulfinpyrazone in treated stroke. N Engl J Med 1978;299:53-59
26. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86.
27. Farrell B, Godwin J, Richards S, Warlow C. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 1991;54:1044-1054
28. The Dutch TIA trial: protective effects of low-dose aspirin and atenolol in patients with transient ischemic attacks or nondisabling stroke: the Dutch TIA Study Group. Stroke 1988;19:512-517
29. Bousser GM, Eschwege E, Haguenau M, et al. "AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of atherothrombotic cerebral ischemia. Stroke 1983;14:5-14.
30. The ESPS Group. The European Stroke Prevention Study (ESPS): principal endpoints. Lancet 1987;2:1351-1354 DOI 10.1016/S0140-6736(87)91254-2
31. Diener HC, Cunha L, Forbes C, et al. European Stroke Prevention Study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996;143:1-13.
32. EAFT Study Group. Secondary prevention in non-rheumatic AF after transient ischaemic attack or minor stroke. Lancet 1993;342:1255-1262 DOI 10.1016/0140-6736(93)92358-Z
33. Product information. Aggrenox (extended-release aspirin and dipyridamole). Ridgefield, CT: Boehringer Ingelheim, March 2001.
34. Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischemic stroke or TIA in high-risk patients (MATCH): randomized, double-blind, placebo-controlled trial. Lancet 2004;364:331-337 DOI 10.1016/S0140-6736(04)16721-4
35. CAPRIE Steering Committee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-1339 DOI 10.1016/S0140-6736(96)09457-3
36. Sacco RL, Diener HC, Yusuf S, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med 2008;359:1238-1251
37. Sacco RL, Adams R, Albers G, et al. Guidelines for the prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention. Stroke 2006;37:577-617. DOI 10.1161/01.STR.0000199147.30016.74 (Pubitemid 43732031)
38. Witt BJ, Brown RD, Jacobsen SJ, et al. A community-based study of stroke incidence after myocardial infarction. Ann Intern Med 2005;143:785-792
39. Lichtman JH, Krumholz HM, Wang Y, et al. Risks and predictors of stroke after MI among the elderly. Results from the co-operative cardiovascular project. Circulation 2002;105:1082-1087 DOI 10.1161/hc0902.104708
40. Boden WE, McKay RG. Optimal treatment of acute coronary syndromes - an evolving strategy. N Engl J Med 2001;344:1939-1942
41. The CURE Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345:494-502.
42. Sabatine MS, Cannon CP, Gibson CM, et al., for the CLARITY-TIMI 28 investigators. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005;352:1179-1189
43. COMMIT collaborative group. Addition of clopidogrel to ASA in 45,852 patients with acute MI. Randomized placebo trial. Lancet 2005;366:1607-1621 DOI 10.1016/S0140-6736(05)67660-X
44. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction. Circulation 2007;116:803-877 DOI 10.1161/CIRCULATIONAHA.107.185752
45. 2007 focused update of the ACC/AHA2004 guidelines for the management of patients with ST-elevation myocardial infarction. J Am Coll Cardiol 2008;51:210-247 DOI10.1016/j.jacc.2007.10.001
46. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. J Am Coll Cardiol 2006;48:e149-246. DOI 10.1016/j.jacc.2006.07.018
47. Singer DE, Albers GW, Dalen JE, et al. Antithrombotic therapy in atrial fibrillation. Chest 2008;133;546-592 DOI 10.1378/chest.08-0678
48. SPAF Investigators. Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation 1991;84:527-539
49. Petersen P, Boysen G, Godtfredsen J, et al. Placebo-controlled randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. Lancet 1989;1:175-179 DOI 10.1016/S0140-6736(89) 91200-2
50. Posada IS, Barriales V, for the LASAF Study group. Alternate-day dosing of aspirin in atrial fibrillation. Am Heart J 1999;138:137-143
51. Sato H, Ishikawa K, Kitabatake A, et al. Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation. Stroke 2006;37:447-451 DOI 10.1161/01.STR.0000198839.61112.ee
52. Hart RG, Benavente O, McBride R, et al. Antithrombotic therapy to prevent stroke in patients with AF: a meta analysis. Ann Intern Med 1999;131:492-501.
53. Aguilar MI, Hart R. Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient attacks. Cochrane Database Syst Rev 2005;(4):CD001925. DOI 10.1002/14651858.CD001925.pub2
54. Segal J, NcNamara RL, Miller MR. Prevention of thromboembolism in atrial fibrillation: a meta-analysis of trials of anticoagulants and antiplatelet drugs. Gen Intern Med 2000;15:56-67.
55. Prati P, Vanuzzo D, Casaroli M, et al. Prevalence and determinants of carotid atherosclerosis in a general population. Stroke 1992;23:1705-1711
56. O'Leary DH, Polak JF, Kronmal RA, et al. Distribution and correlates of sonographically detected carotid artery disease in the cardiovascular health study. The CHS collaborative research group. Stroke 1992;23:1752-1760
57. Ricci S, Flamini FO, Celani MG. Prevalence of internal carotid artery stenosis in subjects older than 49 years: a population study. Cerebrovasc Dis 1991;1:16-19
58. Chaturvedi S, Yadav JS. The role of antiplatelet therapy in carotid stenting for ischemic stroke prevention. Stroke 2006;27:1572-1577 DOI 10.1161/01.STR.0000221298.43117.be
59. Norris JW, Zhu CZ, Bornstein NM, Chambers BR. Vascular risks of asymptomatic carotid stenosis. Stroke 1991;22:1485-1490
60. Inzitari D, Eliasziw M, Gates P, et al. The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 2000;342:1693-1700
61. Barnett HJ, Gunton RW, Eliasziw M, et al. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis. J Am Med Assoc 2000;283:1429-1436 (Pubitemid 30151821)
62. Biller J, Feinberg WM, Castaldo JE, et al. Guidelines for carotid endarterectomy: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Circulation 1998;97:501-509 (Pubitemid 28090224)
63. Boysen G, Sorensen PS, Juhler M, et al. Danish very low dose aspirin after carotid endarterectomy trial. Stroke 1988;19:1211-1215
64. Lindblad B, Persson NH, Takolander R, Bergqvist D. Does low-dose acetylsalicylic acid prevent stroke after carotid surgery? A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1125-1128
65. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis: North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1991;325:445-453
66. Taylor DW, Barnett HJM, Haynes RB, et al. for the ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomized controlled trial. Lancet 1999;353:2179-2184 DOI 10.1016/S0140-6736(99)05388-X
67. Adams RJ, Albers G, Alberts MJ, et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke 2008;39:1647-1652 DOI 10.1161/STROKEAHA.107. 189063
68. Serebruany VL, Steinhubl SR, Berger PB, et al. Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Am J Cardiol 2005;95:1218-1222 DOI.10.1016/j.amjcard.2005.01.049