Preliminary results of a phase I/II clinical trial using in situ photoimmunotherapy combined with imiquimod for metastatic melanoma patients

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7565, Issue , 2010, Pages

  Li, Xiaosong ^a,b   Naylor, Mark F ^c   Nordquist, Robert E ^d   Teague, T Kent ^c,e,f   Howard, C Anthony ^c   Murray, Cynthia ^a   Chen, Wei R ^a  

^a UNIVERSITY OF CENTRAL OKLAHOMA   (United States)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c University of Oklahoma Tulsa College of Medicine   (United States)

^d Wound Healing of Oklahoma   (United States)

^e UNIVERSITY OF OKLAHOMA COLLEGE OF PHARMACY   (United States)

^f OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Cancer immunotherapy; Imiquimod; Immune responses; In situ photoimmunotherapy; Melanoma

Indexed keywords

805-NM LASERS; ADVERSE EFFECT; CANCER IMMUNOTHERAPY; CANCER THERAPY; CLINICAL TRIAL; COMPLETE RESPONSE; IMMUNE RESPONSE; IMMUNOADJUVANTS; IN-SITU; INDOCYANINE GREEN; LEAST ONE CYCLE; MAIN COMPONENT; METASTATIC MELANOMA; OVERALL SURVIVAL; PHOTOIMMUNOTHERAPY; THERAPEUTIC EFFECTS;

DERMATOLOGY; EXPERIMENTS; IMMUNOLOGY;

ONCOLOGY;

EID: 77951579520     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.843260     Document Type: Conference Paper

References (13)

1. Belch, C. M., Buzzard, A. C., Song, S-J., Atkins, M. B., Cascinelli N, Coit, D. G., Fleming, I. D., Gershenwald, J. E., Houghton, A. Jr., Kirkwood, J. M., McMasters, K. M., Mihm, M. F., Morton, D. L., Reintgen, D. S., Ross, M. I., Sober, A., Thompson, J. A., and Thompson, J. F., "Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma," J Clin Oncol 19(16), 3635-3648 (2001). (Pubitemid 32786276)
2. Markovic, S. N., Erickson, L. A., Rao, R. D., Weenig, R. H., Pockaj, B. A., Bardia, A., Vachon, C. M., Schild, S. E., McWilliams, R. R., Hand, J. L., Laman, S. D., Kottschade, L. A., Maples, W. J., Pittelkow, M. R., Pulido, J. S., Cameron, J. D., and Creagan, E. T., "Malignant melanoma in the 21st century, part 2: staging, prognosis, and treatment," Mayo Clin Proc 82(4):364-380 (2007). (Pubitemid 46348938)
3. Tsao, H, Atkins, M. B., and Sober, A. J., "Management of cutaneous melanoma," Nat Clin Pract Oncol 5(1):4-5 (2008).
4. Hill, G. J. 2nd, Krementz, E. T., and Hill H. Z., "Dimethyl triazeno imidazole carboxamide and combination therapy for melanoma. IV. Late results after complete response to chemotherapy (Central Oncology Group protocols 7130, 7131, and 7131A)," Cancer 53(6):1299-1305 (1984).
5. Chen, W. R., Adams, R. L., Carubelli, R., and Nordquist, R. E., "Laser-photosensitizer assisted immunotherapy: A novel modality in cancer treatment," Cancer Lett 115(1):25-30 (1997). (Pubitemid 27139852)
6. den Brok, M. H., Sutmuller, R. P., van der Voort, R., Bennink, E. J., Figdor, C. G., Ruers, T. J., and Adema G. J., "In situ tumor ablation creates an antigen source for the generation of antitumor immunity," Cancer Res 64(11):4024-4029 (2004).
7. Chen, W. R., Zhu, W. G., Dynlacht J. R., Liu H., and Nordquist R. E., "Long-term tumor resistance induced by laser photo-immunotherapy," Int J Cancer 81(5):808-812 (1999). (Pubitemid 29214394)
8. Chen, W. R., Singhal, A. K., Liu, H., and Nordquist, R. E., "Antitumor immunity induced by laser immunotherapy and its adoptive transfer," Cancer Res 61(2):459-461 (2001). (Pubitemid 32128597)
9. Chen, W. R., Jeong, S. W., Lucroy, M. D., Wolf, R. F., Eric Howard, W, Liu, H., and Nordquist, R. E., "Induced antitumor immunity against DMBA-4 metastatic mammary tumors in rats using laser immunotherapy," Int J Cancer 107(6):1053-1057 (2003). (Pubitemid 37429850)
10. Baldridge, J. R., McGowan, P., Evans, J. T., Cluff, C., Mossman, S., Johnson, D., and Persing, D., "Taking a toll on human disease: toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents," Expert Opin Biol Ther 4(7):1129-1138 (2004). (Pubitemid 38937554)
11. Wolf, I. H., Smolle, J., Binder, B., Cerroni, L., Richtig, E., and Kerl, H., "Topical imiquimod in the treatment of metastatic melanoma to skin," Arch Dermatol 139(3):273-276 (2003). (Pubitemid 36330572)
12. Bong, A. B., Bonnekoh, B., Franke, I., Schön, M. P., Ulrich, J., and Gollnick, H., "Imiquimod, a topical immune response modifier, in the treatment of cutaneous metastases of malignant melanoma," Dermatology 205(2):135-138 (2002).
13. http://ctep.cancer.gov/protocolDevelopment/electronic-applications/ docs/ctcaev3.pdf