Determination of minor quantities of polymorph in drug substance: Comparison of near-infrared spectroscopy and x-ray powder diffraction

American Pharmaceutical Review

Volumn 13, Issue 2, 2010, Pages 68-73

  Severdia, Anthony ^a,b   Bhandarkar, Satej ^c   Fogarty, Daniel ^c   Rocco, William ^a,d  

^a Sanofi aventis US R and D   (United States)

^b Delaware County Community College   (United States)

^c Sanofi aventis US Research and Development   (United States)

^d Merck Research and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ARTICLE; CRYSTAL STRUCTURE; DATA ANALYSIS; DRUG FORMULATION; DRUG SYNTHESIS; INTERMETHOD COMPARISON; NEAR INFRARED SPECTROSCOPY; X RAY POWDER DIFFRACTION;

EID: 77951563651     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

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3. Polymorphism in Pharmaceutical Solids, Second Edition (Drugs and the Pharmaceutical Sciences) Harry G. Brittain (Editor) Informa HealthCare; 2nd edition (July 27, 2009)
4. Otsuka, M., Kato, F. and Matsuda, Y., Determination of indomethacin polymorphic contents by chemometric near-infrared spectroscopy and conventional powder X-ray diffractometry, Analyst, 2001, 126, 1578-1582. (Pubitemid 32897043)
5. Patel, A.D., Luner, P. E. and Kemper, M. S., Low-level Determination of Polymorph composition in Physical Mixtures by Near-Infrared Reflectance Spectroscopy, J Pharm Sci 2001, 90, 360-370.
6. Agatonovic-Kustrin S, Wu V, Rades, T, Saville, D, Tucker, I G, Powder diffractometric assay of two polymorphic forms of ranitidine hydrochloride Int J Pharm 1999, 184, 107.
7. Hurst, V.J., Schroeder, P.A., and Styron, R.W. Accurate quantification of quartz and other phases by powder X-ray diffractometry. Analytica Chimica. Acta, 1997, 337, 233-252
8. Campbell Roberts, S.N., Williams A.C., Grimsey, I.M., and Booth S.W., Quantitative analysis of mannitol polymorphs. X-ray powder diffractometry - exploring preferred orientation effects J. Pharm. Biomed. Anal., 2002, 28, 1149-1159.