Assay method for polymer-controlled antibiotic release from allograft bone to target orthopaedic infections

Biomedical Sciences Instrumentation

Volumn 46, Issue , 2010, Pages

  Sevy, Justin O ^a   Slawson, Matthew H ^a   Grainger, David W ^a   Brooks, Amanda E ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Allograft bone; Antibiotic; Controlled drug release; Orthopaedic infection; Polycaprolactone; Tobramycin

Indexed keywords

ALLOGRAFT BONE; ANTIBIOTIC RELEASE; ANTIBIOTIC THERAPY; ASSAY METHODS; BONE FRAGMENTS; BONE GRAFT; BURST RELEASE; CANCELLOUS BONE; CONTROL RELEASE; CONTROL STRATEGIES; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE; DELIVERY VEHICLE; DERIVATIZATION OF; DRUG LOAD; DRUG RELEASE; DRUG RESERVOIR; DRUG RESISTANCE; DYNAMIC RANGE; FLUORESCENT REAGENT; IN-VITRO; LOCAL DELIVERY; LOCAL DRUG DELIVERY; PATIENT COMPLIANCE; POROUS STRUCTURES; PRIMARY AMINE GROUPS; REASONABLE ACCURACY; RELEASE MEDIA; RESISTANT BACTERIA; SIDE EFFECT; STANDARD CURVES; TOBRAMYCIN; WOUND SITE;

BACTERIOLOGY; BONE; CONTROLLED DRUG DELIVERY; GRAFTING (CHEMICAL); PLASTIC COATINGS; POLYCAPROLACTONE; POLYMERS;

ANTIBIOTICS;

PHTHALALDEHYDE; POLYCAPROLACTONE; TOBRAMYCIN;

ACCURACY; ARTICLE; ASSAY; BONE ALLOGRAFT; BONE INFECTION; CANCELLOUS BONE; DRUG CONTROL; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SCREENING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFECTION RISK; MATERIAL COATING; METHODOLOGY; ORTHOPEDICS;

EID: 77951542338     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. A. Nix and D. Wilson, "Assay detection limits: concept, definition, and estimation.," Eur J Clin Pharmacol, vol.39, pp. 203-206, 1990.
2. T. Li, et al., "Development and validation of a third generation allergen-specific IgE assay on the continuous random access IMMULITE 2000 analyzer.," Ann Clin Lab Sci, vol.34, pp. 67-74, 2004.
3. Epsicom 2006 market report Available: https://www.espicom.com/prodcat. nsf/Product-ID-Lookup/00001955?OpenDocument
4. Complications of Orthopedic Surgery. Available: http://www.ofc-oregon. com/assets-ofc/COMPLICATIONS-OF-ORTHOPEDIC-SURGERY.pdf
5. C. Landersdorfer, et al., "Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations.," Clin Pharmacokinet, vol.48, pp. 89-124, 2009.
6. E. Witsø, et al., "Cancellous bone as an antibiotic carrier.," Acta Orthop Scand, vol.71, pp. 80-84, Feb 2000.
7. H. Winkler, et al., "In vitro release of vancomycin and tobramycin from impregnated human and bovine bone grafts.," J Antimicrob Chemother, vol.46, pp. 423-428, Sep 2000.
8. S. C. a. G. M. G. Sivalingam. Enzymatic degradation of poly (-caprolactone), poly (vinyl acetate) and their blends by lipases [Online]. Available: http://www.sciencedirect.com/science?-ob=ArticleURL&
9. A. Aneja, et al., "Analysis of tobramycin release from beta tricalcium phosphate drug delivery system.," Biomed Sci Instrum, vol.44, pp. 88-93, 2008.
10. C. Feng, et al., "Trace analysis of tobramycin in human plasma by derivatization and high-performance liquid chromatography with ultraviolet detection.," J Chromatogr B Analyt Technol Biomed Life Sci, vol.780, pp. 349-354, Nov 2002.
11. M. E. J. Erling B. Pedersen, Michael B. Pedersen , Charlotte Siggaard , Tina B. Sørensen , Gert Mulvad , Jens C. Hansen , Anne M. Torstensen , Ole Aagaard , Henning Skjoldborg, "Plasma amino acids in Greenlanders and Danes. influence of seasons, residence, ethnicity, and diet," American Journal of Human Biology, vol.18, pp. 99-111.
12. A. Carcas, et al., "Tobramycin penetration into epithelial lining fluid of patients with pneumonia.," Clin Pharmacol Ther, vol.65, pp. 245-250, Mar 1999.