Synthesis of 2-(3,4-dihydro-3-oxo-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl) acetic acid derivatives as potential antioxidants in nitrosative stress model

Farmacia

Volumn 58, Issue 2, 2010, Pages 145-157

  Kovalenko, Sergey I ^a   Belenichev, Igor F ^a   Galitsa, Vadim V ^a   Krivoshey, Oksana V ^a  

^a ZAPORIZHZHIA STATE MEDICAL UNIVERSITY   (Ukraine)

Author keywords

2 (3,4 dihydro 3 oxo 2H 1,2,4 triazino 4,3 c quinazolin 4 yl)acetic acid derivatives; Antioxidant activity; Nitrosative stress

Indexed keywords

2 [3,4 DIHYDRO 3 OXO 2H (1,2,4)TRIAZINO(4,3 C) QUINAZOLIN 4 YL]ACETIC ACID; ANTIOXIDANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG SYNTHESIS; FEMALE; MALE; NITROSATIVE STRESS; NONHUMAN; RAT;

EID: 77951532099     PISSN: 00148237     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Claesen, M., Vanderhaeghe, H. Bull. Soc. Chim. Belg. 1959, 68, 220-224
2. (Chem. Abstr. 1960, 54, 9939b).
3. Boldyrev A.A., Role of reactive oxygen species in Functional activity of neuronal cells, Success of physiological science. 2005, 34(3), 21-34 (Rus. Ed.).
4. Fridovich I., Handbook of Methods for Oxygen Radical Research. Boca Raton, EL: CRC. 1987, 256.
5. Gubsky Yu.I., Dunaev V.V., Belenichev I.F., Levitsky E.L., Litvinova N.V., Kovalenko S.I., Buhtiyarova N.V., Afanasenko O.V., Methods of Evaluation of Antioxidant Activity of Compounds at Free Radical Processes Initiation in Experiments In vitro, Methodical Recommendation, State Pharmacological Center of Ministry of Health, Kyiv: Avicenna. 2002, 26 (Ukr. Ed.).
6. Gubsky Yu.I., Belenichev I.F., Levitsky E.L., Kovalenko S.I., Pavlov S.V., Gancheva O.V., Marchenko A.N., Toxicological concequences of protein oxidative modification (POM) at different pathological conditions (literature review), Mod. probl. Toxicology. 2005, 3, 4-20 (Ukr. Ed.).
7. Hausladen A.N. NO and metalloproteins Eur. Cell. Biol.: Suppl. 1998, 48(75), 32-38.
8. Kovalenko S.I., Krivoshey O.V. Substituted (3H-quinazoline-4-yliden) hydrazines in reaction with maleic acid anhydride, Jornal organic and phamaceutical chemistry. 2008, 6, 49-54 (Ukr. Ed.).
9. Misra H.P, Fridovich I., The role of superoxide anione in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol.Chem. 1972, 247, 3170-3175.
10. Parkins C.S., Halder A.L., Dennis M.F., Involvement of oxygen free radicals in ischemia-reperfusion: role of nitric oxide, Free Radical. Res. 1998, 28, 271-281.
11. Pou S., Pou W. Generation of superoxide by brain nitric oxide synthase, J. Biol. Chem. 1992, 267, 24173-24176.
12. Shaban M.A.E., Taha M.A.M., Nasr A.Z., Synthesis of 1,2,4-triazino[4,3-c] quinazolines and 4-(pyrazol-1-yl)quinazolines, Heterocycl. Commun. 1998, 4(5), 473-478.
13. Szobo C. Physiological and pathophysiological role of nitric oxide in the central nervous system, Brain Res. Bull. 1996, 41, 131-141. (Pubitemid 26315139)
14. Trepanier D.L., Sunder S., 1,2,4-Triazino[4,3-c]- and [2,3-c]quinazolines, J. Heterocycl. Chem. 1975, 12, 321-326.
15. Trepanier D.L., Sunder S. 6-(Alkyl)-3,4,6,7-tetrahydro-1,2,4- triazinoquinazolines. Pat. USA 3,919,216. C07D 253/08 The Dow Chemical Company (USA); Chem. Abstr. 1975, 84, 121903.
16. Trepanier D.L., Sunder S. 6-Pyridyl-tetrahydro-1,2,4- triazinoquinazolines. Pat. USA 3,919,219. C07D 253/08 The Dow Chemical Company (USA); Chem. Abstr. 1975, 84, 121906.
17. Trepanier D.L., Sunder S. 6-(Phenyl and substituted phenyl)tetrahydro-1, 2,4-triazinoquinazolines. Pat. USA 3,919,220. C07D 253/08. The Dow Chemical Company (USA); Chem. Abstr. 1975, 84, 121907.
18. Victorov I.V. Role of Nitric oxide and other free radicals in brain ischemic lesions, Herald of Rus. Academy of Med. Sci. 2000, 6, 5-9 (Rus. Ed.).