Pharmaceutical salts optimization of solubility or even more?

American Pharmaceutical Review

Volumn 13, Issue 2, 2010, Pages 18-22

  Saal, Christoph ^a  

^a MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COUNTERION; INORGANIC SALT; SOLVENT;

CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE FORM; DRUG PURITY; DRUG RESEARCH; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; MELTING POINT; PARTICLE SIZE; PHYSICAL CHEMISTRY; SHORT SURVEY; SOLID STATE; STOMACH JUICE; THERMODYNAMICS; THERMOGRAVIMETRY; WETTABILITY;

EID: 77951522350     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (10)

1. R. Hilfiker (Editor), "Polymorphism", Wiley VCH, Weinheim 2006.
2. E.H. Kerns, L. Di, Chapter 7: "Solubility" in "Drug-like Properties: Concepts, Structure, Design and Methods", Elsevier, 2008.
3. C. Lipinski "Drug Solubility in Water and Dimethylsulfoxide" in R. Mannhold (Editor) "Molecular Drug Properties", Wiley VCH, Weinheim, 2008.
4. P.H. Stahl, C.G. Wermuth, "Handbook of Pharmaceutical Salts: Properties, Selection and Use", Wiley VCH, 2002.
5. G.L. Amindon, H. Lennernäs, V.P. Shah, J.R. Crison, "A theoretical basis for a biopharmaceutical drug classification: The correlation of in vivo drug product dissolution and in vivo bioavailability", Pharm. Res. 1995, 12, 413-420.
6. A.W. Newmann, S.M. Reutzel-Edens, G. Zografi, "Characterization of the Hygroscopic Properties of Active Pharmaceutical Ingredients", J. Pharm. Sci. 2008, 97, 1047-1059.
7. ICH Harmonised Tripartite Guideline Q6A: "Specifications: Test Procedures and Acceptance Criteria for new Drug Substances and new Drug Products: Chemical Substances", http://www.ich.org
8. ICH Harmonised Tripartite Guideline Q3C: "Impurities: Guideline for Residual Solvents", http://www.ich.org
9. D.J. Snodin, "Residues of genotoxic alkyl mesylates in mesylate salt drug substances: Real or imaginary problems?" Reg. Tox. Pharm. 2006, 45, 79-90.
10. S. Paulekuhn, J. Dressmann, C. Saal, "Trends in Active Pharmaceutical Ingredient Salt Selection based on Analysis of the Orange Book Database", J. Med. Chem., 2007, 50, 6665-6672.