Correlation of quantified contrast-enhanced sonography with in vivo tumor response

Journal of Ultrasound in Medicine

Volumn 29, Issue 4, 2010, Pages 597-607

  Hwang, Misun ^a   Hariri, Ghazal ^b   Lyshchik, Andrej ^b   Hallahan, Dennis E ^b   Fleischer, Arthur C ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Contrast; Microbubble; Molecular; Sonography; Tumor response

Indexed keywords

BLOOD VESSELS; CHEMOTHERAPY; REGRESSION ANALYSIS; ULTRASONIC APPLICATIONS; ULTRASONIC IMAGING; ULTRASONOGRAPHY;

CONTRAST; CONTRAST-ENHANCED SONOGRAPHIES; IMMUNOHISTOCHEMICAL ANALYSIS; MICRO-BUBBLE; MICROBUBBLE CONTRAST AGENTS; MOLECULAR; POWER DOPPLER VASCULAR INDEX; TUMOR RESPONSE;

TUMORS;

CONTRAST MEDIUM; FLUOROCARBON; PERFLUTREN;

ANIMAL; ARTICLE; C57BL MOUSE; DOPPLER FLOWMETRY; ECHOGRAPHY; HINDLIMB; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; MALE; METHODOLOGY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; RANDOMIZATION; THREE DIMENSIONAL IMAGING;

ANIMALS; CONTRAST MEDIA; FLUOROCARBONS; HINDLIMB; IMAGING, THREE-DIMENSIONAL; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; RANDOM ALLOCATION; ULTRASONOGRAPHY, DOPPLER;

EID: 77951497264     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2010.29.4.597     Document Type: Article

References (13)

1. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-1186.
2. Donnelly EF, Geng L, Wojcicki WE, Fleischer AC, Hallahan DE. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology 2001; 219:166-170.
3. Iordanescu I, Becker C, Zetter B, Dunning P, Taylor GA. Tumor vascularity: evaluation in a murine model with contrast- enhanced color Doppler US effect of angiogenesis inhibitors. Radiology 2002; 222:460-467.
4. Fleischer AC. Sonographic depiction of tumor vascularity and flow: from in vivo models to clinical applications. J Ultrasound Med 2000; 19:55-61.
5. Delorme S, Peschke P, Zuna I, van Kaick G. Imaging the smallest tumor vessels using color Doppler ultrasound in an experiment. Radiologe 2001; 41:168-172.
6. Fleischer AC, Wojcicki WE, Donnelly EF, et al. Quantified color Doppler sonography of tumor vascularity in an animal model. J Ultrasound Med 1999; 18:547-551.
7. Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J Ultrasound Med 2007; 26:1575-1586.
8. Krix M, Kiessling F, Vosseler S, et al. Sensitive noninvasive monitoring of tumor perfusion during antiangiogenic therapy by intermittent bolus-contrast power Doppler sonography. Cancer Res 2003; 63:8264-8270.
9. Davis DW, Inoue K, Dinney CP, Hicklin DJ, Abbruzzese JL, McConkey DJ. Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts. Cancer Res 2004; 64:4601-4610.
10. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998; 97:473-483.
11. Krix M, Kiessling F, Farhan N, Schmidt K, Hoffend J, Delorme S. A multivessel model describing replenishment kinetics of ultrasound contrast agent for quantification of tissue perfusion. Ultrasound Med Biol 2003; 29:1421-1430.
12. Denis F, Bougnoux P, de Poncheville L, Prat M, Catroux R, Tranquart F. In vivo quantitation of tumour vascularisation assessed by Doppler sonography in rat mammary tumours. Ultrasound Med Biol 2002; 28:431-437.
13. Fleischer AC, Lyshchik A, Jones HW Jr, et al. Contrastenhanced transvaginal sonography of benign versus malignant ovarian masses: preliminary findings. J Ultrasound Med 2008; 27:1011-1018.