Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain

Biological Chemistry

Volumn 391, Issue 4, 2010, Pages 435-441

  Cardoso, Cibele C ^a,b   Alenina, Natalia ^a   Ferreira, Anderson J ^b   Qadri, Fatimunnisa ^a   Lima, Mércia P ^b   Gross, Volkmar ^a   Todiras, Mihail ^a   Pesquero, João B ^c   Pesquero, Jorge L ^b   Bader, Michael ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin II; Blood pressure; Tonin; Transgenic mice

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; LISINOPRIL; MESSENGER RNA; POTASSIUM ION; RENIN; SODIUM ION; TONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR AUTOREGULATION; CONFERENCE PAPER; CONTROLLED STUDY; FLUID INTAKE; KIDNEY FUNCTION; MOUSE; NEUROPHYSIOLOGY; NONHUMAN; PLASMA OSMOLARITY; POTASSIUM BLOOD LEVEL; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL; TRANSGENIC MOUSE;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; BRAIN; DRINKING; GENE EXPRESSION; KIDNEY; MICE; MICE, TRANSGENIC; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM; TISSUE KALLIKREINS;

ANIMALIA; MUS; MUS MUSCULUS; RATTUS;

EID: 77951485302     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2010.040     Document Type: Conference Paper

References (36)

1. Aguilera, G. and Kiss, A. (1996). Regulation of the hypothalamicpituitary-adrenal axis and vasopressin secretion: role of angiotensin II. Adv. Exp. Med. Biol. 396, 105-112.
2. Araujo, G.W., Pesquero, J.B., Lindsey, C.J., Paiva, A.C., and Pesquero, J.L. (1991). Identification of serine proteinases with tonin-like activity in the rat submandibular and prostate glands. Biochim. Biophys. Acta 1074, 167-171.
3. Araujo, R.C., Lima, M.P., Lomez, E.S.L., Bader, M., Pesquero, J.B., Sumitani, M., and Pesquero, J.L. (2002). Tonin expression in the rat brain and tonin-mediated central production of angiotensin II. Physiol. Behav. 76, 327-333.
4. Averill, D.B. and Diaz, D.I. (2000). Angiotensin peptides and baroreflex control of sympathetic outflow: pathways and mechanisms of the medulla oblongata. Brain Res. Bull. 51, 119-128.
5. Bader, M. and Ganten, D. (2008). Update on tissue renin-angiotensin systems. J. Mol. Med. 86, 615-621.
6. Baltatu, O. and Bader, M. (2003). Brain renin-angiotensin system. Lessons from functional genomics. Neuroendocrinology 78, 253-259.
7. Baltatu, O., Nishimura, H., Hoffmann, S., Stoltenburg, G., Haulica, I.D., Lippoldt, A., Ganten, D., and Urata, H. (1997). High levels of human chymase expression in the pineal and pituitary glands. Brain Res. 752, 269-278.
8. Baltatu, O., Cayla, C., Iliescu, R., Andreev, D., and Bader, M. (2003). Abolition of end-organ damage by anti-androgen treatment in female hypertensive transgenic rats. Hypertension 41, 830-833.
9. Besnard, F., Brenner, M., Nakatani, Y., Chao, R., Purohit, H.J., and Freese, E. (1991). Multiple interacting sites regulate astrocytesspecific transcription of the human gene for glial fibrillary acidic protein. J. Biol. Chem. 266, 18877-18883.
10. Borges, J.C., Silva, J.A. Jr., Gomes, M.A., Lomez, E.S.L., Araujo, R.C., Bader, M., Pesquero, J.B., and Pesquero, J.L. (2003). Tonin in the rat heart with experimental hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 284, H2263-H2268.
11. Boucher, R., Asselin, J., and Genest, J. (1974). A new enzyme leading to the direct formation of angiotensin II. Circ. Res. 34/35 (Suppl. 1), I203-I209.
12. Cayla, C., Todiras, M., Iliescu, R., Saul, V.V., Gross, V., Pilz, B., Chai, G., Merino, V.M., Pesquero, J.B., Baltatu, O., and Bader M. (2007). Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension. FASEB J. 21, 1689-1698.
13. Davisson, R.L. (2002). Physiological genomic analysis of the brain renin-angiotensin system. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R498-R511.
14. Eng, L.F., Ghirnikar, R.S., and Lee, Y.L. (2000). Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem. Res. 25, 1439-1451.
15. Fitzsimons, J.T. (1998). Angiotensin, thirst, and sodium appetite. Physiol. Rev. 78, 583-686.
16. Grisé, C., Boucher, R., Thibault, G., and Genest, J. (1981). Formation of angiotensin II by tonin from partially purified human angiotensinogen. Can. J. Biochem. 59, 250-255.
17. Gualberto, M.P., Nunes, R.L., Beraldo, W.T., and Pesquero J.L. (1992). Tonin-like activity present in the human submandibular gland. Agents Actions (Suppl.) 38, 392-400.
18. Hall, J.E. (2003). Historical perspective of the renin-angiotensin system. Mol. Biotechnol. 24, 27-39.
19. Kondo, K., Garcia, R., Boucher, R., and Genest, J. (1980). Effects of intracerebroventricular administration of tonin on water intake and blood pressure in the rat. Brain Res. 200, 437-441.
20. Lawes, C.M.M., Vander Hoorn, S., and Rodgers, A. (2008). Global burden of blood-pressure-related diseases, 2001. Lancet 371, 1513-1518.
21. Livak, K.J. and Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT method. Methods 25, 402-408.
22. Lomez, E.S.L., Araujo, R.C., Bader, M., Pesquero, J.B., and Pesquero, J.L. (2002). Tonin and kallikrein in the brain of transgenic rat line expressing human tissue kallikrein. Hypertension 39, 229-232.
23. Lopes, E.S., Sumitani, M., Juliano, L., Beraldo, W.T., and Pesquero J.L. (1997). Distribution of tonin- and kallikrein-like activities in the rat brain. Brain Res. 769, 152-157.
24. Monti, J., Schinke, M., Böhm, M., Ganten, D., Bader, M., and Bricca, G. (2001). Glial angiotensinogen regulates brain angiotensin II receptors in transgenic rats TGR(ASrAOGEN). Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R233-R240.
25. Morimoto, S., Cassell, M.D., Beltz, T.G., Johnson, A.K., Davisson, R.L., and Sigmund, C.D. (2001). Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ. Res. 89, 365-372.
26. Paul, M., Mehr, A.L., and Kreutz, R. (2006). Physiology of local renin-angiotensin system. Physiol. Rev. 86, 747-803.
27. Pesquero, J.B., Lindsey, C.J., Zeh, K., Paiva, A.C., Ganten, D., and Bader, M. (1994). Molecular structure and expression of rat bradykinin B2 receptor gene. Evidence for alternative splicing. J. Biol. Chem. 269, 26920-26925.
28. Plehm, R., Barbosa, M.E., and Bader M. (2006). Animal models for hypertension/blood pressure recording. Methods Mol. Med. 129, 115-126.
29. Popova, E., Bader, M., and Krivokharchenko, A. (2005). Strain differences in superovulatory response, embryo development and efficiency of transgenic rat production. Transgenic Res. 14, 877-880.
30. Reid, A.L. (1992). Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure. Am. J. Physiol. 262, E763-E778.
31. Schiffrin, E.L., Garcia, R., Gutkowska, J., Boucher, R., and Genest, J. (1981). Pressor effect of tonin in anephric animals. Can. J. Physiol. Pharmacol. 59, 864-871.
32. Schinke, M., Baltatu, O., Böhm, M., Peters, J., Bricca, G., Lippoldt, A., Ganten, D., and Bader, M. (1999). Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen. Proc. Natl. Acad. Sci. USA 96, 3975-3980.
33. Touyz, R.M. and Schiffrin, E.L. (2000). Signal transduction mechanism mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev. 52, 639-672.
34. Urata, H., Nishimura, H., and Ganten, D. (1996). Chymase-dependent angiotensin II forming systems in humans. Am. J. Hypertens. 9, 277-284.
35. Woodley-Miller, C., Chao, J., and Chao, L. (1987). Identification of tonin in brain and exocrine tissues and in the cell-free translation products encoded by mRNA of these tissue. Biochem. J. 248, 477-481.
36. Zacharatos, D.T., Vasak, E.Z., Chen, E.S.P., van Lennep, E.W., and Morris, B.J. (1983). Immunohistochemistry of tonin in the rat submandibular gland during development, lactation and secretion. Histochemistry 79, 433-442.