Monitoring the particle size and shape in the crystallization of paracetamol from water

Chemical Engineering Research and Design

Volumn 88, Issue 4, 2010, Pages 447-454

  Kempkes, Michel ^a   Vetter, Thomas ^a   Mazzotti, Marco ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Crystallization; Imaging; Instrumentation; Particle shape; Particle size; Particulate processes

Indexed keywords

AVERAGE GROWTH RATE; COOLING CRYSTALLIZATION; COOLING RATES; ELECTRON MICROSCOPY IMAGES; IMAGING INSTRUMENTATION; IN-LINE; PARACETAMOL; PARTICLE SHAPE; PARTICLE SIZE AND SHAPE; PARTICULATE PROCESS; STIRRING RATES;

CRYSTALLIZATION; INSTRUMENTS; ORE TREATMENT; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY;

SUSPENSIONS (FLUIDS);

EID: 77951297100     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2009.09.006     Document Type: Article

References (12)

1. Briesen H. Simulation of crystal size and shape by means of a reduced two-dimensional population balance model. Chemical Engineering Science 2006, 61(1):104-112.
2. Eggers J., Kempkes M., Mazzotti M. Measurement of size and shape distributions of particles through image analysis. Chemical Engineering Science 2008, 63(22):5513-5521.
3. Kempkes M., Eggers J., Mazzotti M. Measurement of particle size and shape by FBRM and in situ microscopy. Chemical Engineering Science 2008, 63(19):4656-4675.
4. Oullion M., Puel F., Févotte G., Righini S., Carvin P. Industrial batch crystallization of a plate-like organic product. In situ monitoring and 2D-CSD modelling. Part 1: experimental study. Chemical Engineering Science 2007, 62(3):820-832.
5. Oullion M., Puel F., Févotte G., Righini S., Carvin P. Industrial batch crystallization of a plate-like organic product. In situ monitoring and 2D-CSD modelling. Part 2: kinetic modelling and identification. Chemical Engineering Science 2007, 62(3):833-845.
6. Puel F., Marchal P., Klein J. Habit transient analysis in industrial crystallization using two dimensional crystal sizing technique. Chemical Engineering Research & Design 1997, 75(A2):193-205.
7. Puel F., Févotte G., Klein J.P. Simulation and analysis of industrial crystallization processes through multidimensional population balance equations. Part 1: a resolution algorithm based on the method of classes. Chemical Engineering Science 2003, 58(16):3715-3727.
8. Puel F., Févotte G., Klein J.P. Simulation and analysis of industrial crystallization processes through multidimensional population balance equations. Part 2: a study of semi-batch crystallization. Chemical Engineering Science 2003, 58(16):3729-3740.
9. Ristic R.I., Finnie S., Sheen D.B., Sherwood J.N. Macro- and micromorphology of monoclinic paracetamol grown from pure aqueous solution. Journal of Physical Chemistry B 2001, 105:9057-9066.
10. Variankaval N., Cote A.S., Doherty M.F. From form to function: crystallization of active pharmaceutical ingredients. AIChE Journal 2008, 54(7):1682-1688.
11. Wang X.Z., Calderon de Anda J., Roberts K.J. Real-time measurement of the growth rates of individual crystal facets using imaging and image analysis: a feasibility on needle-shaped crystals of l-glutamic acid. Chemical Engineering Research & Design 2007, 85A:921-927.
12. Wang X.Z., Roberts K.J., Ma C. Crystal growth measurement using 2D and 3D imaging and the perspectives for shape control. Chemical Engineering Science 2008, 63(5):1173-1184.