BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer - A population based study from the Western Sweden Health Care region

Acta Oncologica

Volumn 49, Issue 3, 2010, Pages 361-367

  Einbeigi, Zakaria ^a   Enerbäck, Charlotta ^a   Wallgren, Arne ^a   Nordling, Margareta ^a   Karlsson, Per ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER GENETICS; CANCER INCIDENCE; CANCER RISK; FEMALE; FOLLOW UP; GENE MUTATION; GENETIC COUNSELING; HEALTH CARE; HUMAN; MAJOR CLINICAL STUDY; MUTATION RATE; ONCOGENE; OUTPATIENT DEPARTMENT; OVARY CANCER; POPULATION; PREDICTION AND FORECASTING; PRIORITY JOURNAL; RELATIVE; SWEDEN;

ADULT; AGE OF ONSET; AGED; BREAST NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; GENES, BRCA1; GENES, BRCA2; GENETIC COUNSELING; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HETEROZYGOTE; HUMANS; INCIDENCE; JEWS; MIDDLE AGED; MUTATION; OVARIAN NEOPLASMS; POPULATION SURVEILLANCE; PREDICTIVE VALUE OF TESTS; REGISTRIES; RISK ASSESSMENT; RISK FACTORS; SWEDEN;

EID: 77951293346     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/02841860903521095     Document Type: Article

References (19)

1. Easton DF, Ford D, Bishop DT. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet 1995;56:265-271
2. Einbeigi Z, Meis-Kindblom JM, Kindblom LG, Wallgren A, Karlsson P. Clustering of individuals with both breast and ovarian cancer-a possible indicator of BRCA founder mutations. Acta Oncol 2002;41:153-157 (Pubitemid 34557075)
3. Bergfeldt K, Rydh B, Granath F, Grönberg H, Thalib L, Adami H-O, et al. Risk of ovarian cancer in breast-cancer patients with a family history of breast or ovarian cancer: A population-based cohort study. Lancet 2002;360:891-894 (Pubitemid 35283831)
4. Ferla R, Calo V, Cascio S, Rinaldi G, Badalamenti G, Carreca I, et al. Founder mutations in BRCA1 and BRCA2 genes. Ann Oncol 2007;18(Suppl 6):vi93-8.
5. Lubinski J, Korzen M, Gorski B, Cybulski C, Debniak T, Jakubowska A, et al. Breast cancer susceptibility genes. J Buon 2007;12(Suppl 1):S23-9. (Pubitemid 350200858)
6. Konstantopoulou I, Rampias T, Ladopoulou A, Koutsodontis G, Armaou S, Anagnostopoulos T, et al. Greek BRCA1 and BRCA2 mutation spectrum: Two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients. Breast Cancer Res Treat 2008;107:431-441 (Pubitemid 351172120)
7. Bergman A, Flodin A, Engwall Y, Arkblad EL, Berg K, Einbeigi Z, et al. A high frequency of germline BRCA1/2 mutations in western Sweden detected with complementary screening techniques. Fam Cancer 2005;4:89-96. (Pubitemid 40897808)
8. Einbeigi Z. Hereditary brast and ovarian cancer in western Sweden. Gothenburg: University of Gothenburg; 2004.
9. Einbeigi Z, Bergman A, Meis-Kindblom JM, Flodin A, Bjursell C, Martinsson T, et al. Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: A population-based study from Western Sweden. Fam Cancer 2006;6:35-41. (Pubitemid 46295295)
10. Holmberg E, Anderson H, Lundell M, Karlsson P. The impact of reproductive factors on breast cancer risk-the feasibility of using Swedish population-based registers to account for the effect of confounding in cohort studies. Cancer Causes Control 2005;16:235-243 (Pubitemid 40897842)
11. Einbeigi Z, Bergman A, Kindblom LG, Martinsson T, Meis-Kindblom JM, Nordling M, et al. A founder mutation of the BRCA1 gene in Western Sweden associated with a high incidence of breast and ovarian cancer. Eur J Cancer 2001; 37:1904-1909 (Pubitemid 32913319)
12. Bergman A, Einbeigi Z, Olofsson U, Taib Z, Wallgren A, Karlsson P, et al. The western Swedish BRCA1 founder mutation 3171ins5;a 3.7 cM conserved haplotype of today is a reminiscence of a 1500-year-old mutation. Eur J Hum Genet 2001;9:787-793 (Pubitemid 33014592)
13. Johannsson O, Ostermeyer EA, Hakansson S, Friedman LS, Johansson U, Sellberg G, et al. Founding BRCA1 mutations in hereditary breast and ovarian cancer in southern Sweden. Am J Hum Genet 1996;58:441-450 (Pubitemid 26062474)
14. Hakansson S, Johannsson O, Johansson U, Sellberg G, Loman N, Gerdes AM, et al. Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer. Am J Hum Genet 1997;60:1068-1078 (Pubitemid 27194091)
15. Dorum A, Hovig E, Trope C, Inganas M, Moller P. Three per cent of Norwegian ovarian cancers are caused by BRCA1 1675delA or 1135insA. Eur J Cancer 1999;35:779-781 (Pubitemid 29258148)
16. Malander S, Ridderheim M, Masback A, Loman N, Kristoffersson U, Olsson H, et al. One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: Results of a prospective study in Southern Sweden. Eur J Cancer 2004; 40:422-428 (Pubitemid 38121280)
17. Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 2001;68: 700-710 (Pubitemid 32203724)
18. Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: A combined analysis of 22 studies. Am J Hum Genet 2003;72: 1117-1130 (Pubitemid 36530000)
19. Metcalfe KA, Finch A, Poll A, Horsman D, Kim-Sing C, Scott J, et al. Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation. Br J Cancer 2009;100: 421-425