Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration

Dermatologic Surgery

Volumn 36, Issue 5, 2010, Pages 618-622

  Yoo, Kwang Ho ^a   Lee, Jin Woong ^a   Li, Kapsok ^a   Kim, Beom Joon ^a   Kim, Myeung Nam ^a  

^a Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID METHYL ESTER; CORTICOSTEROID; CYCLOSPORIN; DIPHENCYPRONE; PSORALEN; STEROID;

ADULT; ALOPECIA AREATA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; HAIR FOLLICLE; HAIR GROWTH; HUMAN; KOREA; MALE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RED LIGHT; SCALP; SKIN PENETRATION; TREATMENT RESPONSE; ULTRAVIOLET A RADIATION;

ADULT; ALOPECIA AREATA; AMINOLEVULINIC ACID; BIOPSY; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; FEMALE; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, INTRADERMAL; MALE; MINIATURIZATION; NEEDLES; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PILOT PROJECTS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77951282544     PISSN: 10760512     EISSN: 15244725     Source Type: Journal    
DOI: 10.1111/j.1524-4725.2010.01515.x     Document Type: Article

References (16)

1. Wasserman D, Araucaria Guzman-Sanchez D, Scott K, McMichael A. Alopecia areata. Int J Dermatol 2007 46 : 121 131.
2. Shapiro J, Price VH. Hair regrowth. Therapeutic agents. Dermatol Clin 1998 16 : 341 356.
3. Lehmann P. Methyl aminolaevulinate-photodynamic therapy: a review of clinical trials in the treatment of actinic keratoses and nonmelanoma skin cancer. Br J Dermatol 2007 156 : 793 801.
4. Klein A, Babilas P, Karrer S, et al. Photodynamic therapy in dermatology - an update 2008. J Dtsch Dermatol Ges 2008 6 : 839 845.
5. Taylor CR, Hawk JL. PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years' experience at St John's Institute of Dermatology. Br J Dermatol 1995 133 : 914 918.
6. Da Monfrecola GF, Delfino M. Topical hematoporphyrin plus UVA for the treatment of alopecia areata. Photodermatology 1987 4 : 305 306.
7. Bissonette R, Shapiro J, Zeng H, et al. Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata. Br J Dermatol 2000 143 : 1032 1035.
8. Fernández-Guarino M, Harto A, García-Morales I, et al. Failure to treat alopecia areata with photodynamic therapy. Clin Exp Dermatol 2008 33 : 585 587.
9. Morokuma Y, Yamazaki M, Maeda T, et al. Hair growth stimulatory effect by a combination of 5-aminolevulinic acid and iron ion. Int J Dermatol 2008 47 : 1298 1303.
10. Yoon J, Son T, Choi EH, et al. Enhancement of optical skin clearing efficacy using a microneedle roller. J Biomed Opt 2008 13 : 0211103.
11. Wiegell SR, Stender I-M, Na R, Wulf HC. Pain associated with photodynamic therapy using 5-aminolevulinic acid or 5-aminolevulinic acid methylester on tape-stripped normal skin. Arch Dermatol 2003 139 : 1173 1177.
12. Al-Qallaf B, Das DB. Optimizing microneedle arrays to increase skin permeability for transdermal drug delivery. Ann N Y Acad Sci 2009 1161 : 83 94.
13. Gilhar A, Ullmann Y, Berkutzki T, et al. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 1998 101 : 62 7.
14. Noodt BB, Berg K, Stokke T, et al. Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX. Br J Cancer 1996 74 : 22 9.
15. Webber J, Luo Y, Crilly R, et al. An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo. J Photochem Photobiol B Biol 1996 35 : 209 211.
16. Mitchell AJ, Douglass MC. Topical photochemotherapy for alopecia areata. J Am Acad Dermatol 1985 12 : 644 649.