Efficacy of alpha-lipoic acid against diabetes-induced deterioration of blood antioxidants and diabetic retinopathy in experimental animals

Australian Journal of Basic and Applied Sciences

Volumn 4, Issue 2, 2010, Pages 127-134

  El Hossary, Ghada Ghanem ^a   El Shazly, Amany Hassan M ^a   Ahmed, Nadia Samy ^a   El Gohary, Amal Ahmed ^a   Metwally, Fatma Gamal ^a   Karam, Sawsan Hanafy ^a  

^a RESEARCH INSTITUTE OF OPHTHALMOLOGY   (Egypt)

Author keywords

Alpha lipoic acid; Antioxidant; Diabetic retinopathy; Experimental diabetes mellitus; Glutathione; Vitamin C

Indexed keywords

EID: 77951273665     PISSN: 19918178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Akpinar, D., P. Yargicoglu, N. Derin, Y. Alicigzel, M. Sahin and A. Agar, 2007. The effect of lipoic acid on lipid peroxidation and visual evoked potentials in rats exposed to chronic restraint stress. Int. J. Neurosci., 117 (12): 1691-1706.
2. Berkowitz, B.A., R. Roberts, A. Stemmler, H. Luan and M. Gradianu, 2007. Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic acid. Invest. Ophthalmol. Vis. Sci., 48(10): 4753-4758.
3. Beutler, E., O. Duran, and B. Kelly, 1963. Improved method for the determination of blood glutathione. J. lab. Clin. Med., 61: 882.
4. Biewenga, G.P., G.R. Haenen and A. Bast, 1997. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol., 29: 315-331.
5. Bregovskii, V.B., O.V. Posokhina and I.A. Karpova, 2005. Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs. Ter. Arkh., 77(10): 15-19.
6. Derin, N., D. Akpinar, P. Yargicoglu, A. Agar and M. Aslan, 2009. Effect of alpha-lipoic acid on visual evoked potentials in rats exposed to sulfite. Neurotoxicol. Teratol., 31(1): 34-39.
7. Drury, R.A. and E.A. Wallington, 1980. Carleton's histological techniques. Oxford Univ. Press, pp: 241-242.
8. Friedman, E.A., 1999. Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications. Diabetes care, 22(Suppl. 2): 65-71.
9. Gavrovskaia, L.K., O.V. Ryzhova, A.F. Safonova, I.I. Aleksandrova and N.S. Sapronov, 2008. Effect of taurine and thiotacide on carbohydrate metabolism and the antioxidant system in rats with experimental diabetes. Eksp. Klin. Farmakol., 71(3): 34-35.
10. Henriksen, E.J., 2006. Exercise Training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radic. Biol. Med., 40(1): 3-12.
11. Jogata, S.A. and H. M. Dani, 1982. A new colorimetric technique for the estimation of vitamin C using folin phenol reagent. Anal. Biochem., 127: 178.
12. Johnsen-Soriano, S., M. Garcia-Pous, E. Arnal, M. Sancho-Tello, S. Garcia-Delpech, M. Miranda, F. Bosch-Morell, M. Dias-Liopis, A. Navea and F.J. Romero, 2008. Early lipoic acid intake protects the retina of diabetic mice. Free Radic. Res., 42(7): 613-617.
13. Komeima, K., B.S. Rogers and P.A. Campochiaro, 2007. Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa. J. Cell. Physiol., 213(3): 809-815.
14. Kowluru, R.A., L. Atasi, Y.S. Ho, 2006. Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci., 47(4): 1594-1599.
15. Lin, J., A. Bierhaus, P. Bugert, N. Dietrich, Y. Feng, F. Vom Hagen, P. Nawroth, M. Brownlee, H.P. Hammes, 2006. Effect of R-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia, 49(5): 1089-1096.
16. Malinska, D. and K. Winiarska, 2005. Lipoic acid: characteristics and therapeutic applications. Postepy. Hig. Med. Dosw., 59: 535-543.
17. Mizutani, M., T.S. Kern and M. Lorenzi, 1996. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J. Clin. Invest., 97: 2883-2890.
18. Negrisanu, G., M. Rosu, B. Bolte, D. Lefter and D. Dabelea, 1999. Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom. J. Intern. Med., 37(3): 297-306.
19. Noh, H., H.H. Kangsw, K.H. Choi, D.S. Han and H.Y. Lee, 2002. High glucose increases inducible NO production in cultured rat mesengial cells. Possible role in fibronectin production. Nephron., 90(1): 78-85.
20. Packer, L., K. Kraemer and G. Rimbach, 2001. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition, 17(10): 888-895.
21. Siest, G., J. Henry and F. Schiele, 1981. Enzymatic determination of glucose. Interpretation des examens de laboratoire. Ed. Karger, D. pp: 206.
22. Stadler, K., V. Jenei, A. Somogyi and J. Takus, 2004. Aminoguanidine prevents peroxynitrite production and cardiac hypertrophy in streptozocin induced diabetic rats. Orv. Hetil. Study, 145(49): 2491-2496.
23. Stoppa, G.R., M. Cesquini, E.A. Roma, S.H. Ogo and M.A. Torsoni, 2006. Aminoguanidine prevented impairment of blood antioxidant system in insulin dependent diabetic rats. Life Sci., 78(12): 1352-1361.
24. Stoyanovsky, D.A., R. Goldman, R.M. Darrow, D.T. Organisciak and V.E. Kagan, 1995. Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid. Curr. Eye Res., 14(3): 181-189.
25. Tankova, T., D. Koev and L. Dakovska, 2004. Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy. Rom. J. Intern. Med., 42(2): 457-464.
26. Winiarska, K., D. Naninska, K. Szymanski, M. Dudziak and J. Bryla, 2008. Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits. Biochimie., 90(3): 450-459.
27. Ziegler, D., 2004. Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat. Endocrinol., 3(3): 173-189.