A prospective molecular surveillance study evaluating the clinical impact of community-acquired respiratory viruses in lung transplant recipients

Transplantation

Volumn 89, Issue 8, 2010, Pages 1028-1033

  Kumar, Deepali ^a   Husain, Shahid ^b,g   Chen, Maggie Hong ^b   Moussa, George ^c   Himsworth, David ^d   Manuel, Oriol ^e   Studer, Sean ^f   Pakstis, Diana ^f   McCurry, Kenneth ^f   Doucette, Karen ^a   Pilewski, Joseph ^f   Janeczko, Richard ^d   Humar, Atul ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d Luminex Molecular Diagnostics   (Canada)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^g UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Acute rejection; Bronchiolitis obliterans syndrome; Influenza; Luminex xTAG assay; Rhinovirus

Indexed keywords

ALEMTUZUMAB; CORTICOSTEROID; COTRIMOXAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OSELTAMIVIR; PREDNISONE; TACROLIMUS; VALGANCICLOVIR; VORICONAZOLE;

ADULT; ARTICLE; BACTERIAL INFECTION; BRONCHIOLITIS OBLITERANS; CLINICAL FEATURE; CONTROLLED STUDY; CORONAVIRUS; DISEASE ASSOCIATION; EXPIRATORY RESERVE VOLUME; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; INFLUENZA; INFLUENZA VIRUS; LOW DRUG DOSE; LUNG BIOPSY; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; METAPNEUMOVIRUS; MYCOSIS; PARAINFLUENZA VIRUS 1; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY VIRUS; RNA VIRUS INFECTION; VIRAL RESPIRATORY TRACT INFECTION; VIRUS INFECTION;

ACUTE DISEASE; ADULT; BIOPSY; BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; FORCED EXPIRATORY VOLUME; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PENNSYLVANIA; POPULATION SURVEILLANCE; PROSPECTIVE STUDIES; RESPIRATORY TRACT INFECTIONS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 77951268269     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181d05a71     Document Type: Article

References (23)

1. Vilchez R, McCurry K, Dauber J, et al. Influenza and parainfluenza respiratory viral infection requiring admission in adult lung transplant recipients. Transplantation 2002; 73: 1075.
2. Garantziotis S, Howell DN, McAdams HP, et al. Influenza pneumonia in lung transplant recipients: Clinical features and association with bronchiolitis obliterans syndrome. Chest 2001; 119: 1277.
3. Kumar D, Erdman D, Keshavjee S, et al. Clinical impactof community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. Am J Transplant 2005; 5: 2031.
4. Husain S, Singh N. Bronchiolitis obliterans and lung transplantation: Evidence for an infectious etiology. Semin Respir Infect 2002; 17: 310.
5. Larcher C, Geltner C, Fischer H, et al. Human metapneumovirus infection in lung transplant recipients: Clinical presentation and epidemiology. J Heart Lung Transplant 2005; 24: 1891.
6. Kaiser L, Aubert JD, Pache JC, et al. Chronic rhinoviral infection in lung transplant recipients. Am J Respir Crit Care Med 2006; 174: 1392.
7. Mahony J, Chong S, Merante F, et al. Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay. J Clin Micro-biol 2007; 45: 2965.
8. Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant 1996; 15: 1.
9. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: An update of the diagnostic criteria. J Heart Lung Transplant 2002; 21: 297.
10. American Society of Transplantation. Guidelines for the prevention and management of infectious complications of solid organ transplantation: Community-acquired respiratory viruses. Am J Transplant 2004; 4: 105.
11. McCurry KR, Iacono A, Zeevi A, et al. Early outcomes in human lung transplantation with thymoglobulin or Campath-1H for recipient pre-treatment followed by posttransplant tacrolimus near-monotherapy. J Thorac Cardiovasc Surg 2005; 130: 528.
12. Husain S, Paterson DL, Studer S, et al. Voriconazole prophylaxis in lung transplant recipients. Am J Transplant 2006; 6: 3008.
13. Khalifah AP, Hachem RR, Chakinala MM, et al. Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death. Am J Respir Crit Care Med 2004; 170C: 18o1.ntacting th
14. Garbino J, Gerbase MW, Wunderli W, et al. Respiratory viruses and severe lower respiratory tract complications in hospitalized patients. Chest 2004; 125: 1033.
15. Milstone AP, Brumble LM, Barnes J, et al. A single-season prospective study of respiratory viral infections in lung transplant recipients. Eur Respir J 2006; 28: 131.
16. Nichols WG, Guthrie KA, Corey L, et al. Influenza infections after hematopoietic stem cell transplantation: Risk factors, mortality, and the effect of antiviral therapy. Clin Infect Dis 2004; 39: 1300.
17. Ison MG, Sharma A, Shepard JA, et al. Outcome of influenza infection managed with oseltamivir in lung transplant recipients. J Heart Lung Transplant 2008; 27: 282.
18. Gerna G, Vitulo P, Rovida F, et al. Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients. J Med Virol 2006; 78: 408.
19. Wendt CH, Fox JM, Hertz MI. Paramyxovirus infection in lung transplant recipients. J Heart Lung Transplant 1995; 14: 479.
20. McCurdy LH, Milstone A, Dummer S. Clinical features and outcomes of paramyxoviral infection in lung transplant recipients treated with ribavirin. J Heart Lung Transplant 2003; 22: 745.
21. Pelaez A, Lyon GM, Force SD, et al. Efficacy of oral ribavirin in lung transplant patients with respiratory syncytial virus lower respiratory tract infection. J Heart Lung Transplant 2009; 28: 67.
22. Glanville AR, Scott AI, Morton JM, et al. Intravenous ribavirin is a safe and cost-effective treatment for respiratory syncytial virus infection after lung transplantation. J Heart Lung Transplant 2005; 24: 2114.
23. Hayden FG, Herrington DT, Coats TL, et al; Pleconaril Respiratory EdIt rneif aettcmotioernn tiSoatuf dlcyolOGdsrodfuupfe.itEcof feipciac coyrnaanvdirsuasfeestyinofadouraltls:plReceosunlatrsiloffo2r double-blind, randomized, placebo-controlled trials. Clin Infect Dis 2003; 36: 1523.