α- and β-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy

Journal of Molecular Medicine

Volumn 88, Issue 2, 2010, Pages 203-217

  Ferrandi, Mara ^a   Cusi, Daniele ^b,c   Molinari, Isabella ^a   Del Vecchio, Lucia ^d   Barlassina, Cristina ^b,c   Rastaldi, Maria Pia ^e   Schena, Francesco Paolo ^f   MacCiardi, Fabio ^b,j   Marcantoni, Carmelita ^g   Roccatello, Dario ^h   Peters, Luanne L ⁱ   Armelloni, Silvia ^e   Min, Li ^e   Giardino, Laura ^e   Mattinzoli, Deborah ^e   Camisasca, Claudio ^a   Palazzo, Fiorentina ^a   Manunta, Paolo ^k   Ferrari, Patrizia ^a   Bianchi, Giuseppe ^k  

^a Prassis Sigma Tau Research Institute   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Genomics and Bioinformatics Unit   (Italy)

^d A MANZONI HOSPITAL   (Italy)

^e FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^f UNIVERSITY OF BARI   (Italy)

^g UNIVERSITY HOSPITAL OF VERONA   (Italy)

^h UNIVERSITY OF TURIN   (Italy)

ⁱ JACKSON LABORATORY   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k SAN RAFFAELE HOSPITAL   (Italy)

more..

Author keywords

Adducin; Genetic renal disease; Glomerular disease; IgA nephropathy; Podocytes; Proteinuria

Indexed keywords

ADDUCIN; ALPHA ACTININ; ALPHA ADDUCIN; BETA ADDUCIN; CELL PROTEIN; CREATININE; IMMUNOGLOBULIN A; NEPHRIN; PHOSPHONEPHRIN; PODOCIN; PROTEIN; PROTEIN KINASE FYN; PROTEIN ZO1; SYNAPTOPODIN; UNCLASSIFIED DRUG; URIC ACID;

ADULT; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; FEMALE; GENE DELETION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GLOMERULOPATHY; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY INTERSTITIUM; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN URINE LEVEL; PROTEINURIA; RAT; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION; WESTERN BLOTTING;

ANIMALS; CALMODULIN-BINDING PROTEINS; GLOMERULONEPHRITIS, IGA; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS; MICE; PODOCYTES; POLYMORPHISM, GENETIC; PROTEINURIA; RATS; RODENTIA;

EID: 77951252401     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0549-x     Document Type: Article

References (37)

1. RC Wiggins 2007 The spectrum of podocytopathies: a unifying view of glomerular disease Kidney Int 71 1205 1214 10.1038/sj.ki.5002222 1:STN:280:DC%2BD2szjvFKiuw%3D%3D 17410103 (Pubitemid 46884251)
2. P Aaltonen H Holthofer 2007 Nephrin and related proteins in the pathogenesis of nephropathy Drug Discov Today Dis Mech 4 21 27 10.1016/j.ddmec.2007.06.003 Renal diseases (Pubitemid 351966325)
3. PW Mathieson 2008 Podocyte-specific gene mutations are coming of age J Am Soc Nephrol 19 190 191 10.1681/ASN.2007121341 18216304 (Pubitemid 351240637)
4. B Hinkes C Vlangos S Heeringa B Mucha R Gbadegesin J Liu K Hasselbacher F Ozaltin F Hildebrandt APN Study Group 2008 Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome J Am Soc Nephrol 19 365 371 10.1681/ASN.2007040452 18216321 (Pubitemid 351240657)
5. PG Tipping 2008 Are podocytes passive or provocative in proteinuric glomerular pathology? J Am Soc Nephrol 19 651 653 10.1681/ASN.2008020156 18322155
6. Y Matsuoka X Li V Bennett 2000 Adducin: structure, function and regulation Cell Mol Life Sci 57 884 895 10.1007/PL00000731 1:CAS:528: DC%2BD3cXlsl2gsrs%3D 10950304
7. G Tripodi F Valtorta L Torielli E Chieregatti S Salardi L Trusolino A Menegon P Ferrari PC Marchisio G Bianchi 1996 Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport J Clin Invest 97 2815 2822 10.1172/JCI118737 1:CAS:528: DyaK28XjvVWks7k%3D 8675693
8. G Bianchi G Tripodi G Casari S Salardi BR Barber R Garcia P Leoni L Torielli D Cusi M Ferrandi LA Pinna FE Baralle P Ferrari 1994 Two point mutations within the adducin genes are involved in blood pressure variation Proc Natl Acad Sci 91 3999 4003 10.1073/pnas.91.9.3999 1:CAS:528:DyaK2cXktVagsL0%3D 8171025
9. D Cusi C Barlassina T Azzani G Casari L Citterio M Devoto N Glorioso C Lanzani P Manunta M Righetti R Rivera P Stella C Troffa L Zagato G Bianchi 1997 Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension Lancet 349 1353 1357 10.1016/S0140-6736(97)01029-5 1:CAS:528:DyaK2sXjsFejtrg%3D 9149697 (Pubitemid 27197537)
10. G Bianchi 2005 Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms Am J Physiol Regul Integr Comp Physiol 289 R1536 R1549 1:CAS:528: DC%2BD28XlslGqtw%3D%3D 16278339
11. P Manunta G Lavery C Lanzani PS Braund M Simonini C Bodycote L Zagato S Delli Carpini C Tantardini E Brioni G Bianchi NJ Samani 2008 Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation Hypertension 52 366 372 10.1161/HYPERTENSIONAHA.108. 113977 1:CAS:528:DC%2BD1cXosFyqu7k%3D 18591455
12. JA Staessen JG Wang E Brand C Barlassina WH Birkenhäger SM Herrmann R Fagard L Tizzoni G Bianchi 2001 Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population J Hypertens 19 1349 1358 10.1097/00004872-200108000-00002 1:CAS:528:DC%2BD3MXlvF2mtrY%3D 11518842 (Pubitemid 32730451)
13. JG Wang JA Staessen L Tizzoni E Brand WH Birkenhäger R Fagard SM Herrmann G Bianchi 2001 Renal function in relation to three candidate genes Am J Kidney Dis 38 1158 1168 10.1053/ajkd.2001.29205 1:CAS:528: DC%2BD38XisFCksA%3D%3D 11728946
14. J Nicod BM Frey FJ Frey P Ferrari 2002 Role of the alpha-adducin genotype on renal disease progression Kidney Int 61 1270 1275 10.1046/j.1523-1755.2002. 00275.x 1:CAS:528:DC%2BD38XjtVGqtrs%3D 11918733 (Pubitemid 34304487)
15. I Narita S Goto N Saito J Song J Ajiro F Sato D Saga D Kondo K Akazawa M Sakatsume F Gejyo 2003 Interaction between ACE and ADD1 gene polymorphisms in the progression of IgA nephropathy in Japanese patients Hypertension 42 304 309 10.1161/01.HYP.0000085193.25617.78 1:CAS:528:DC%2BD3sXmslSju7w%3D 12885793 (Pubitemid 37093477)
16. E Beeks MM van der Klauw AA Kroon W Spiering MJ Fuss-Lejeune PW de Leeuw 2004 Alpha-adducin Gly460Trp polymorphism and renal hemodynamics in essential hypertension Hypertension 44 419 423 10.1161/01.HYP.0000141410.72537.fd 1:CAS:528:DC%2BD2cXnslenu7g%3D 15326084 (Pubitemid 39281489)
17. M Merta J Reiterová J Stekrová R Rysava Z Rihová V Tesar O Viklický D Kmentova 2003 Influence of the alpha-adducin and ACE gene polymorphism on the progression of autosomal-dominant polycystic kidney disease Kidney Blood Press Res 26 42 49 10.1159/000069768 1:CAS:528: DC%2BD3sXivFOhtr4%3D 12697976 (Pubitemid 36438800)
18. G D'Amico 1987 The commonest glomerulonephritis in the world: IgA nephropathy Q J Med 64 709 727 3329736
19. B Mackinnon EP Fraser DC Cattran JG Fox CC Geddes 2008 Validation of the Toronto formula to predict progression in IgA nephropathy Nephron Clin Prac 109 148 153 10.1159/000145458
20. DM Gilligan L Lozovatsky B Gwynn C Brugnara N Mohandas LL Peters 1999 Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice Proc Natl Acad Sci 96 10717 10722 10.1073/pnas.96.19.10717 1:CAS:528:DyaK1MXmtFKjsrs%3D 10485892 (Pubitemid 29442210)
21. G Tripodi M Florio M Ferrandi R Modica H Zimdahl N Hubner P Ferrari G Bianchi 2004 Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats Biochem Biophys Res Commun 324 562 568 10.1016/j.bbrc.2004.09.079 1:CAS:528:DC%2BD2cXotlCmsrw%3D 15474463 (Pubitemid 39345553)
22. HM Regele E Fillipovic B Langer H Poczewki I Kraxberger RE Bittner D Kerjaschki 2000 Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis J Am Soc Nephrol 11 403 412 1:CAS:528:DC%2BD3cXhslWmsL4%3D 10703664
23. LP Bartosik G Lajoie L Sugar DC Cattran 2001 Predicting progression in IgA nephropathy Am J Kidney Dis 38 728 735 10.1053/ajkd.2001.27689 1:STN:280:DC%2BD3MrivF2nsA%3D%3D 11576875 (Pubitemid 33666517)
24. DW Cockcroft MH Gault 1976 Prediction of creatinine clearance from serum creatinine Nephron 16 31 41 10.1159/000180580 1:STN:280:DyaE28%2FnsF2isw%3D%3D 1244564
25. G D'Amico A Ragni E Gandini G Fellin 1993 Typical and atypical natural history of IgA nephropathy in adult patients Contrib Nephrol 104 6 13 8325035
26. SM Lee VM Rao WA Franklin MS Schiffer AJ Aronson BH Spargo AI Katz 1982 IgA nephropathy: morphologic predictors of progressive renal disease Hum Pathol 13 314 322 10.1016/S0046-8177(82)80221-9 1:STN:280:DyaL387ovVCrug%3D%3D 7076216 (Pubitemid 12105183)
27. JG Wang JA Staessen C Barlassina R Fagard T Kuznetsova HA Struijker-Boudier L Zagato L Citterio E Messaggio G Bianchi 2002 Association between hypertension and variation in the α- and β-adducin genes in a white population Kidney Int 62 2152 2159 10.1046/j.1523-1755.2002.00691.x 1:CAS:528:DC%2BD38XpsFKlur8%3D 12427140 (Pubitemid 35366170)
28. Neter J, Wasserman W, Kutner MH (1985) Applied linear statistical models, 2nd edn. Irwin, Homewood
29. A Brandis G Bianchi E Reale U Helmchen K Kühn 1986 Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain Lab Invest 55 234 243 1:STN:280:DyaL283otlWmsQ%3D%3D 3736022
30. G Pugliese C Ricci C Iacobini S Menini P Fioretto M Ferrandi LA Giardino S Armelloni D Mattinzoli MP Rastaldi F Pugliese 2007 Glomerular barrier dysfunction in glomerulosclerosis-resistant Milan rats with experimental diabetes: the role of renal haemodynamics J Pathol 213 210 218 10.1002/path.2226 1:CAS:528:DC%2BD2sXhtlWjsLrJ 17768702 (Pubitemid 47612243)
31. F Pugliese P Mene GA Cinotti 1986 Glomerular prostaglandins and thromboxane synthesis in normotensive and hypertensive rats of the Milan strain before and after development of hypertension J Hypertension 4 S391 S393 1:CAS:528:DyaL2sXot1Cqsg%3D%3D
32. JF Mann RE Schmieder M McQueen L Dyal H Schumacher J Pogue X Wang A Maggioni A Budaj S Chaithiraphan K Dickstein M Keltai K Metsärinne A Oto A Parkhomenko LS Piegas TL Svendsen KK Teo S Yusuf 2008 Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomized, double-blind, controlled trial Lancet 372 547 553 10.1016/S0140-6736(08)61236-2 1:CAS:528:DC%2BD1cXpvFKgsLs%3D 18707986
33. Y Li L Zagato T Kuznetsova G Tripodi G Zerbini T Richart L Thijs P Manunta JG Wang G Bianchi JA Staessen 2007 Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome Hypertension 49 1291 1297 10.1161/HYPERTENSIONAHA.106.085498 1:CAS:528:DC%2BD2sXltl2hs7k%3D 17452507 (Pubitemid 46809371)
34. C Faul K Asanuma E Yanagida-Asanuma K Kim P Mundel 2007 Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton Trends Cell Biol 17 428 437 10.1016/j.tcb.2007.06.006 1:CAS:528:DC%2BD2sXhtFeiur%2FJ 17804239 (Pubitemid 47499042)
35. R Verma I Kovari A Soofi D Nihalani K Patrie LB Holzman 2006 Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization J Clin Invest 116 1346 1359 10.1172/JCI27414 1:CAS:528:DC%2BD28XksVWns7s%3D 16543952
36. N Jones IM Blasutig V Eremina JM Ruston F Bladt H Li H Huang L Larose SS Li T Takano SE Quaggin T Pawson 2006 Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes Nature 440 818 823 10.1038/nature04662 1:CAS:528:DC%2BD28XjtFKjsbY%3D 16525419
37. H Gotoh N Okumura T Yagi A Okumura T Shima K Nagai 2006 Fyn-induced phosphorylation of beta-adducin at tyrosine 489 and its role in their subcellular localization Biochem Biophys Res Commun 346 600 605 10.1016/j.bbrc.2006.05.167 1:CAS:528:DC%2BD28XlvFGmt7c%3D 16765915 (Pubitemid 43902725)