An epitope of Bacillus anthracis protective antigen that is cryptic in rabbits may be immunodominant in humans : Authors' Reply

Infection and Immunity

Volumn 78, Issue 5, 2010, Pages 2353-2354

  Oscherwitz, Jon ^a   Cease, Kemp B ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX VACCINE; BACTERIAL ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; PROTECTIVE ANTIGEN 305-319; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTHRAX; ANTIBODY RESPONSE; ANTIGEN RECOGNITION; BACILLUS ANTHRACIS; CELLULAR IMMUNITY; ENZYME LINKED IMMUNOSPOT ASSAY; HELPER CELL; HUMAN; IMMUNOGENICITY; IMMUNOSTIMULATION; LETTER; NONHUMAN; PRIORITY JOURNAL; RABBIT; T LYMPHOCYTE;

EID: 77951250968     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00072-10     Document Type: Letter

References (8)

1. Bou-Habib, D. C., G. Roderiquez, T. Oravecz, P. W. Berman, P. Lusso, and M. A. Norcross. 1994. Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization. J. Virol. 68:6006-6013. (Pubitemid 24258617)
2. Ekiert, D. C., G. Bhabha, M. A. Elsliger, R. H. Friesen, M. Jongeneelen, M. Throsby, J. Goudsmit, and I. A. Wilson. 2009. Antibody recognition of a highly conserved influenza virus epitope. Science 324:246-251.
3. Lacy, D. B., D. J. Wigelsworth, R. A. Melnyk, S. C. Harrison, and R. J. Collier. 2004. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc. Natl. Acad. Sci. U. S. A. 101:13147-13151.
4. Oscherwitz, J., F. Yu, and K. B. Cease. 2009. A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen. Infect. Immun. 77:5509-5518.
5. Oscherwitz, J., F. Yu, J. L. Jacobs, T. H. Liu, P. R. Johnson, and K. B. Cease. 2009. Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen. Infect. Immun. 77:3380-3388.
6. Rajewsky, K., V. Schirrmacher, S. Nase, and N. K. Jerne. 1969. The requirement of more than one antigenic determinant for immunogenicity. J. Exp. Med. 129:1131-1143.
7. Rathore, D., R. Nagarkatti, D. Jani, R. Chattopadhyay, P. de la Vega, S. Kumar, and T. F. McCutchan. 2005. An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion. J. Biol. Chem. 280:20524-20529.
8. Sui, J., W. C. Hwang, S. Perez, G. Wei, D. Aird, L. M. Chen, E. Santelli, B. Stec, G. Cadwell, M. Ali, H. Wan, A. Murakami, A. Yammanuru, T. Han, N. J. Cox, L. A. Bankston, R. O. Donis, R. C. Liddington, and W. A. Marasco. 2009. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 16:265-273.