Effect of oxymatrine on JAK/STAT iteral in rat lung tissue with sepsis

Zhongguo Zhongyao Zazhi

Volumn 35, Issue 1, 2010, Pages 103-107

  Zhang, Minghao ^a   Li, Guizhong ^a   Cao, Jun ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Cell factor; JAK STAT; Lung injury; Oxymatrine; Sepsis

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 2; OXYMATRINE; STAT PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ALKALOID; QUINOLIZINE DERIVATIVE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CECAL LIGATION AND PUNCTURE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRY WEIGHT; ENZYME ACTIVITY; GRANULOCYTE; HISTOPATHOLOGY; HYPEREMIA; IMMUNOHISTOCHEMISTRY; INFERIOR CAVA VEIN; LIGATION; LOW DRUG DOSE; LUNG; LUNG EDEMA; LUNG PARENCHYMA; LUNG WEIGHT; MALE; MICROSCOPE; MICROSCOPY; NONHUMAN; PUNCTURE; RADIOIMMUNOASSAY; RAT; SEPSIS; SHAM PROCEDURE; TISSUE HOMOGENATE; WET DEPOSITION; ANIMAL; DRUG EFFECT; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ACUTE LUNG INJURY; ALKALOIDS; ANIMALS; IMMUNOHISTOCHEMISTRY; JANUS KINASES; LUNG; MALE; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; STAT3 TRANSCRIPTION FACTOR;

EID: 77951243572     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20100122     Document Type: Article

References (13)

1. Martin G S, Mannino D M, Eaton S, et al. The epidemiology of sepsis in the United State from 1979 through 2000[J]. N Engl J Med, 2003,348:1546.
2. Silva E, Passos Rda H. MB-693, Sepsis: from bench to bedside[J]. Clinics, 2008,63(1):109.
3. Liu X, Ye L, Bai Y, et al. Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG[J]. J Immunol, 2008,181(1):449.
4. Shi G F, Li Q. Effects of oxymatrine on experimental hepatic fibrosis and its mechanism in vitro [J]. World J Gastroenterol, 2005,11(2):268 (Pubitemid 40125217)
5. Das U N. Is insulin an antiinflammatory molecule[J]. Nutriton, 2001,17(5):409.
6. Zheng P, Niu F L, Liu W Z, et al. Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats[J]. World J Gastroenterol, 2005,11(31):4912. (Pubitemid 41223310)
7. Xu G L, Yao L, Rao S Y, et al. Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase[J]. J Ethnopharmacol, 2005,98(1/2):177. (Pubitemid 40349184)