Neuroprotective effect of extract of Ginkgo biloba against excitotoxicty compared with ginkgolide B in neuron cell of rat

Zhongguo Zhongyao Zazhi

Volumn 35, Issue 1, 2010, Pages 114-117

  Xu, Jing ^a   Sun, Changkai ^a   Ma, Hui ^a   Wang, Lu ^a   Zhang, Jian ^a   Zhang, Yumei ^a   Wu, Lanxiang ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

EGb761; GB; Glutamate; Hippocampal neuron

Indexed keywords

DIZOCILPINE; GINKGO BILOBA EXTRACT; GINKGOLIDE B; GLUTAMIC ACID; LACTATE DEHYDROGENASE; TRYPAN BLUE; DIZOCILPINE MALEATE; GINKGO BILOBA EXTRACT 761; GINKGOLIDE; HERBACEOUS AGENT; LACTONE; NEUROPROTECTIVE AGENT; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EXCITOTOXICITY; GINKGO BILOBA; HIPPOCAMPUS; ISOLATION PROCEDURE; NERVE CELL; NEUROPROTECTION; NICK END LABELING; NONHUMAN; RAT; ANIMAL; CHEMISTRY; DRUG EFFECT; METABOLISM; NEWBORN; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DIZOCILPINE MALEATE; DRUGS, CHINESE HERBAL; GINKGO BILOBA; GINKGOLIDES; IN SITU NICK-END LABELING; L-LACTATE DEHYDROGENASE; LACTONES; NEURONS; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77951235386     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20100124     Document Type: Article

References (12)

1. Gasic G P, Hollmann M. Molecular neurobiology of glutamate receptors [J]. Annu Rev Physiol, 1992, 54: 507.
2. D'Ambrosio R. Does glutamate released by astrocytes cause focal epilepsy[ J]. Epilepsy Curr, 2006 6 (5): 173.
3. Mitsios N, Gaffney J, Kumar P, et al. Pathophysiology of acute ischaemic stroke: An analysis of common signalling mechanisms and identification of new molecular targets [J]. Pathobiology, 2006, 73 (4): 159. (Pubitemid 44808076)
4. Gallen C C. Strategic challenges in neurotherapeutic pharmaceutical development [J]. NeuroRx, 2004, 1: 165.
5. Ramassamy C, Longpr F, Christen Y. Ginkgo biloba extract (EGb 761) in Alzheimer's disease: Is there any evidence[J]. Curr Alzheimer Res, 2007,4 (3) : 253.
6. Ding A S, Wang F Z, Yu S, et al. Effecte of hypoxic-preconditioning on anoxic-tolerance and Hsp70 expression in cultured rat hippocampal neurons [J]. Chin J Neurosci, 2001, 17: 51.
7. Michaels R L, Rothman S M. Glutamate neurotoxicity in vitro: Antagonist pharmacology and intracellular calcium concentrations [J]. Neurosci, 1990, 10: 283.
8. Prehn J H, Lippert K, Krieglstein J. Are NMDA or AMPA/kainite receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury[J]. Eur J Pharmacol, 1995, 292:179.
9. Gardoni F, Di L M. New targets for pharmacological intervention in the glutamatergic synapse [J]. Eur J Pharmacol, 2006, 545: 2. (Pubitemid 44215874)
10. Gertz H J, Kiefer M. Review about Ginkgo biloba special extract EGb 761 (Ginkgo) [J]. Curr Pharm Des, 2004, 10 (3): 261.
11. VAN BEEK T A. Ginkgolides and bilobalide: Their physical, Chromatographic and spectroscopic properties [J]. Bioorg Med Chem, 2005, 13 : 5001.