메뉴 건너뛰기




Volumn 137, Issue 9, 2010, Pages 1493-1503

Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability

Author keywords

Drosophila; Epithelial morphogenesis; Von Hippel Lindau tumor suppressor gene

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; PACLITAXEL; PROTEIN KINASE C; VON HIPPEL LINDAU PROTEIN; DROSOPHILA PROTEIN; PROTEIN KINASE C ALPHA;

EID: 77951219416     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.042804     Document Type: Article
Times cited : (17)

References (51)
  • 1
    • 0034213624 scopus 로고    scopus 로고
    • Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
    • Adryan, B., Decker, H. J., Papas, T. S. and Hsu, T. (2000). Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila. Oncogene 19, 2803-2811. (Pubitemid 30386416)
    • (2000) Oncogene , vol.19 , Issue.24 , pp. 2803-2811
    • Adryan, B.1    Decker, H.-J.H.2    Papas, T.S.3    Hsu, T.4
  • 2
  • 3
    • 0034675358 scopus 로고    scopus 로고
    • Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity
    • Aso, T., Yamazaki, K., Aigaki, T. and Kitajima, S. (2000). Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. Biochem. Biophys. Res. Commun. 276, 355-361.
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 355-361
    • Aso, T.1    Yamazaki, K.2    Aigaki, T.3    Kitajima, S.4
  • 4
    • 33751191831 scopus 로고    scopus 로고
    • Generation of noncentrosomal microtubule arrays
    • Bartolini, F. and Gundersen, G. G. (2006). Generation of noncentrosomal microtubule arrays. J. Cell Sci. 119, 4155-4163.
    • (2006) J. Cell Sci. , vol.119 , pp. 4155-4163
    • Bartolini, F.1    Gundersen, G.G.2
  • 5
    • 13444267951 scopus 로고    scopus 로고
    • Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae
    • Betschinger, J., Eisenhaber, F. and Knoblich, J. A. (2005). Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae. Curr. Biol. 15, 276-282.
    • (2005) Curr. Biol. , vol.15 , pp. 276-282
    • Betschinger, J.1    Eisenhaber, F.2    Knoblich, J.A.3
  • 6
    • 0037228253 scopus 로고    scopus 로고
    • Integrated activity of PDZ protein complexes regulates epithelial polarity
    • Bilder, D., Schober, M. and Perrimon, N. (2003). Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat. Cell Biol. 5, 53-58.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 53-58
    • Bilder, D.1    Schober, M.2    Perrimon, N.3
  • 7
    • 32944457801 scopus 로고    scopus 로고
    • Von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
    • DOI 10.1158/0008-5472.CAN-05-3236
    • Calzada, M. J., Esteban, M. A., Feijoo-Cuaresma, M., Castellanos, M. C., Naranjo-Suarez, S., Temes, E., Mendez, F., Yanez-Mo, M., Ohh, M. and Landazuri, M. O. (2006). von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms. Cancer Res. 66, 1553-1560. (Pubitemid 43259937)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1553-1560
    • Calzada, M.J.1    Esteban, M.A.2    Feijoo-Cuaresma, M.3    Castellanos, M.C.4    Naranjo-Suarez, S.5    Temes, E.6    Mendez, F.7    Yanez-Mo, M.8    Ohh, M.9    Landazuri, M.O.10
  • 8
    • 49649105572 scopus 로고    scopus 로고
    • Endothelial function of von Hippel-Lindau tumor suppressor gene: Control of fibroblast growth factor receptor signaling
    • Champion, K. J., Guinea, M., Dammai, V. and Hsu, T. (2008). Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. Cancer Res. 68, 4649-4657.
    • (2008) Cancer Res , vol.68 , pp. 4649-4657
    • Champion, K.J.1    Guinea, M.2    Dammai, V.3    Hsu, T.4
  • 10
    • 33745819269 scopus 로고    scopus 로고
    • Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
    • Esteban, M. A., Harten, S. K., Tran, M. G. and Maxwell, P. H. (2006). Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J. Am. Soc. Nephrol. 17, 1801-1806.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 1801-1806
    • Esteban, M.A.1    Harten, S.K.2    Tran, M.G.3    Maxwell, P.H.4
  • 12
    • 36749102487 scopus 로고    scopus 로고
    • Multitasking by pVHL in tumour suppression
    • Frew, I. J. and Krek, W. (2007). Multitasking by pVHL in tumour suppression. Curr. Opin. Cell Biol. 19, 685-690.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 685-690
    • Frew, I.J.1    Krek, W.2
  • 13
    • 9644265474 scopus 로고    scopus 로고
    • The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo
    • DOI 10.1038/sj.onc.1208023
    • Grifoni, D., Garoia, F., Schimanski, C. C., Schmitz, G., Laurenti, E., Galle, P. R., Pession, A., Cavicchi, S. and Strand, D. (2004). The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Oncogene 23, 8688-8694. (Pubitemid 39576476)
    • (2004) Oncogene , vol.23 , Issue.53 , pp. 8688-8694
    • Grifoni, D.1    Garoia, F.2    Schimanski, C.C.3    Schmitz, G.4    Laurenti, E.5    Galle, P.R.6    Pession, A.7    Cavicchi, S.8    Strand, D.9
  • 14
    • 34247593781 scopus 로고    scopus 로고
    • aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    • Harris, T. J. and Peifer, M. (2007). aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Dev. Cell 12, 727-738.
    • (2007) Dev. Cell , vol.12 , pp. 727-738
    • Harris, T.J.1    Peifer, M.2
  • 15
    • 64049084322 scopus 로고    scopus 로고
    • Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin
    • Harten, S. K., Shukla, D., Barod, R., Hergovich, A., Balda, M. S., Matter, K., Esteban, M. A. and Maxwell, P. H. (2009). Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin. Mol. Biol. Cell 20, 1089-1101.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1089-1101
    • Harten, S.K.1    Shukla, D.2    Barod, R.3    Hergovich, A.4    Balda, M.S.5    Matter, K.6    Esteban, M.A.7    Maxwell, P.H.8
  • 16
    • 0037223823 scopus 로고    scopus 로고
    • Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
    • Hergovich, A., Lisztwan, J., Barry, R., Ballschmieter, P. and Krek, W. (2003). Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat. Cell Biol. 5, 64-70.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 64-70
    • Hergovich, A.1    Lisztwan, J.2    Barry, R.3    Ballschmieter, P.4    Krek, W.5
  • 17
    • 33744954679 scopus 로고    scopus 로고
    • Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility
    • Hsu, T., Adereth, Y., Kose, N. and Dammai, V. (2006). Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J. Biol. Chem. 281, 12069-12080.
    • (2006) J. Biol. Chem. , vol.281 , pp. 12069-12080
    • Hsu, T.1    Adereth, Y.2    Kose, N.3    Dammai, V.4
  • 18
    • 2942626082 scopus 로고    scopus 로고
    • Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis
    • DOI 10.1016/j.devcel.2004.05.003, PII S1534580704001662
    • Hutterer, A., Betschinger, J., Petronczki, M. and Knoblich, J. A. (2004). Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev. Cell 6, 845-854. (Pubitemid 38745418)
    • (2004) Developmental Cell , vol.6 , Issue.6 , pp. 845-854
    • Hutterer, A.1    Betschinger, J.2    Petronczki, M.3    Knoblich, J.A.4
  • 19
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin, W. G., Jr (2008). The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat. Rev. Cancer 8, 865-873.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 865-873
    • Kaelin Jr., W.G.1
  • 20
    • 0037032804 scopus 로고    scopus 로고
    • Composition and formation of intercellular junctions in epithelial cells
    • DOI 10.1126/science.1072161
    • Knust, E. and Bossinger, O. (2002). Composition and formation of intercellular junctions in epithelial cells. Science 298, 1955-1959. (Pubitemid 35425244)
    • (2002) Science , vol.298 , Issue.5600 , pp. 1955-1959
    • Knust, E.1    Bossinger, O.2
  • 21
    • 8644253684 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery
    • Lolkema, M. P., Mehra, N., Jorna, A. S., van Beest, M., Giles, R. H. and Voest, E. E. (2004). The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery. Exp. Cell Res. 301, 139-146.
    • (2004) Exp. Cell Res. , vol.301 , pp. 139-146
    • Lolkema, M.P.1    Mehra, N.2    Jorna, A.S.3    Van Beest, M.4    Giles, R.H.5    Voest, E.E.6
  • 22
    • 34548684136 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2
    • DOI 10.1016/j.febslet.2007.08.050, PII S0014579307009209
    • Lolkema, M. P., Mans, D. A., Snijckers, C. M., van Noort, M., van Beest, M., Voest, E. E. and Giles, R. H. (2007). The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 581, 4571-4576. (Pubitemid 47418779)
    • (2007) FEBS Letters , vol.581 , Issue.24 , pp. 4571-4576
    • Lolkema, M.P.1    Mans, D.A.2    Snijckers, C.M.3    Van Noort, M.4    Van Beest, M.5    Voest, E.E.6    Giles, R.H.7
  • 23
    • 37249036930 scopus 로고    scopus 로고
    • Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor
    • Lolkema, M. P., Mans, D. A., Ulfman, L. H., Volpi, S., Voest, E. E. and Giles, R. H. (2008). Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor. Eur. J. Hum. Genet. 16, 73-78.
    • (2008) Eur. J. Hum. Genet. , vol.16 , pp. 73-78
    • Lolkema, M.P.1    Mans, D.A.2    Ulfman, L.H.3    Volpi, S.4    Voest, E.E.5    Giles, R.H.6
  • 24
    • 33746886185 scopus 로고    scopus 로고
    • Primary cilium formation requires von hippel-lindau gene function in renal-derived cells
    • Lutz, M. S. and Burk, R. D. (2006). Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res. 66, 6903-6907.
    • (2006) Cancer Res , vol.66 , pp. 6903-6907
    • Lutz, M.S.1    Burk, R.D.2
  • 25
    • 67349232437 scopus 로고    scopus 로고
    • Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
    • Mortimer, N. T. and Moberg, K. H. (2009). Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Dev. Biol. 329, 294-305.
    • (2009) Dev. Biol. , vol.329 , pp. 294-305
    • Mortimer, N.T.1    Moberg, K.H.2
  • 26
    • 0742289586 scopus 로고    scopus 로고
    • Microtubule organization and function in epithelial cells
    • DOI 10.1111/j.1600-0854.2003.00149.x
    • Musch, A. (2004). Microtubule organization and function in epithelial cells. Traffic 5, 1-9. (Pubitemid 38159399)
    • (2004) Traffic , vol.5 , Issue.1 , pp. 1-9
    • Musch, A.1
  • 27
    • 0037452071 scopus 로고    scopus 로고
    • Adaptation of core mechanisms to generate cell polarity
    • Nelson, W. J. (2003). Adaptation of core mechanisms to generate cell polarity. Nature 422, 766-774.
    • (2003) Nature , vol.422 , pp. 766-774
    • Nelson, W.J.1
  • 29
    • 0027323552 scopus 로고
    • The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction
    • Peifer, M. (1993). The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. J. Cell Sci. 105, 993-1000.
    • (1993) J. Cell Sci. , vol.105 , pp. 993-1000
    • Peifer, M.1
  • 30
    • 38449092945 scopus 로고    scopus 로고
    • A protocol for culturing Drosophila melanogaster stage 9 egg chambers for live imaging
    • Prasad, M., Jang, A. C., Starz-Gaiano, M., Melani, M. and Montell, D. J. (2007). A protocol for culturing Drosophila melanogaster stage 9 egg chambers for live imaging. Nat. Protoc. 2, 2467-2473.
    • (2007) Nat. Protoc. , vol.2 , pp. 2467-2473
    • Prasad, M.1    Jang, A.C.2    Starz-Gaiano, M.3    Melani, M.4    Montell, D.J.5
  • 31
    • 0030782345 scopus 로고    scopus 로고
    • Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo
    • Queenan, A. M., Ghabrial, A. and Schupbach, T. (1997). Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124, 3871-3880. (Pubitemid 27482984)
    • (1997) Development , vol.124 , Issue.19 , pp. 3871-3880
    • Queenan, A.M.1    Ghabrial, A.2    Schupbach, T.3
  • 33
    • 33749663052 scopus 로고    scopus 로고
    • The positive regulation of p53 by the tumor suppressor VHL
    • Roe, J. S. and Youn, H. D. (2006). The positive regulation of p53 by the tumor suppressor VHL. Cell Cycle 5, 2054-2056. (Pubitemid 44553737)
    • (2006) Cell Cycle , vol.5 , Issue.18 , pp. 2054-2056
    • Roe, J.-S.1    Youn, H.-D.2
  • 34
    • 0034674713 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in Drosophila
    • Rong, Y. S. and Golic, K. G. (2000). Gene targeting by homologous recombination in Drosophila. Science 288, 2013-2018.
    • (2000) Science , vol.288 , pp. 2013-2018
    • Rong, Y.S.1    Golic, K.G.2
  • 37
    • 4143119015 scopus 로고    scopus 로고
    • DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    • DOI 10.1083/jcb.200311031
    • Sotillos, S., Diaz-Meco, M. T., Caminero, E., Moscat, J. and Campuzano, S. (2004). DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J. Cell Biol. 166, 549-557. (Pubitemid 39097174)
    • (2004) Journal of Cell Biology , vol.166 , Issue.4 , pp. 549-557
    • Sotillos, S.1    Diaz-Meco, M.T.2    Caminero, E.3    Moscat, J.4    Campuzano, S.5
  • 38
    • 33645746316 scopus 로고    scopus 로고
    • The PAR-aPKC system: Lessons in polarity
    • Suzuki, A. and Ohno, S. (2006). The PAR-aPKC system: lessons in polarity. J. Cell Sci. 119, 979-987.
    • (2006) J. Cell Sci. , vol.119 , pp. 979-987
    • Suzuki, A.1    Ohno, S.2
  • 39
    • 0037225708 scopus 로고    scopus 로고
    • Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization
    • Tanentzapf, G. and Tepass, U. (2003). Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat. Cell. Biol. 5, 46-52.
    • (2003) Nat. Cell. Biol. , vol.5 , pp. 46-52
    • Tanentzapf, G.1    Tepass, U.2
  • 40
    • 0034645049 scopus 로고    scopus 로고
    • Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
    • Tanentzapf, G., Smith, C., McGlade, J. and Tepass, U. (2000). Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. J. Cell Biol. 151, 891-904.
    • (2000) J. Cell Biol. , vol.151 , pp. 891-904
    • Tanentzapf, G.1    Smith, C.2    McGlade, J.3    Tepass, U.4
  • 41
    • 0035984637 scopus 로고    scopus 로고
    • Adherens junctions: New insight into assembly, modulation and function
    • Tepass, U. (2002). Adherens junctions: new insight into assembly, modulation and function. BioEssays 24, 690-695.
    • (2002) BioEssays , vol.24 , pp. 690-695
    • Tepass, U.1
  • 42
    • 0025285657 scopus 로고
    • Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • DOI 10.1016/0092-8674(90)90189-L
    • Tepass, U., Theres, C. and Knust, E. (1990). crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61, 787-799. (Pubitemid 20185639)
    • (1990) Cell , vol.61 , Issue.5 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 43
    • 0028130363 scopus 로고
    • Microtubules and cytoplasm organization during Drosophila oogenesis
    • Theurkauf, W. E. (1994). Microtubules and cytoplasm organization during Drosophila oogenesis. Dev. Biol. 165, 352-360.
    • (1994) Dev. Biol. , vol.165 , pp. 352-360
    • Theurkauf, W.E.1
  • 45
    • 41649083427 scopus 로고    scopus 로고
    • Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
    • Tian, A. G. and Deng, W. M. (2008). Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development 135, 463-471.
    • (2008) Development , vol.135 , pp. 463-471
    • Tian, A.G.1    Deng, W.M.2
  • 46
    • 0029045343 scopus 로고
    • Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
    • Wodarz, A., Hinz, U., Engelbert, M. and Knust, E. (1995). Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82, 67-76.
    • (1995) Cell , vol.82 , pp. 67-76
    • Wodarz, A.1    Hinz, U.2    Engelbert, M.3    Knust, E.4
  • 47
    • 0033518223 scopus 로고    scopus 로고
    • Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    • Wodarz, A., Ramrath, A., Kuchinke, U. and Knust, E. (1999). Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402, 544-547.
    • (1999) Nature , vol.402 , pp. 544-547
    • Wodarz, A.1    Ramrath, A.2    Kuchinke, U.3    Knust, E.4
  • 48
    • 0027267041 scopus 로고
    • Analysis of genetic mosaics in developing and adult Drosophila tissues
    • Xu, T. and Rubin, G. M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237. (Pubitemid 23154489)
    • (1993) Development , vol.117 , Issue.4 , pp. 1223-1237
    • Xu, T.1    Rubin, G.M.2
  • 50
    • 34948883495 scopus 로고    scopus 로고
    • PVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-kappaB Agonist Card9 by CK2
    • DOI 10.1016/j.molcel.2007.09.010, PII S1097276507006223
    • Yang, H., Minamishima, Y. A., Yan, Q., Schlisio, S., Ebert, B. L., Zhang, X., Zhang, L., Kim, W. Y., Olumi, A. F. and Kaelin, W. G., Jr (2007). pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Mol. Cell 28, 15-27. (Pubitemid 47531976)
    • (2007) Molecular Cell , vol.28 , Issue.1 , pp. 15-27
    • Yang, H.1    Minamishima, Y.A.2    Yan, Q.3    Schlisio, S.4    Ebert, B.L.5    Zhang, X.6    Zhang, L.7    Kim, W.Y.8    Olumi, A.F.9    Kaelin Jr., W.G.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.