Striking LD50 variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl4 exposure in mice

Virchows Archiv

Volumn 456, Issue 4, 2010, Pages 423-431

  Irie, Hiroshi ^a   Asano Hoshino, Anshin ^a   Sekino, Yoshihisa ^a   Nogami, Makoto ^a   Kitagawa, Tomoyuki ^b   Kanda, Hiroaki ^b  

^a TEIKYO UNIVERSITY   (Japan)

^b Cancer Research Institute   (Japan)

Author keywords

Apoptosis; Carbon tetrachloride; Centrilobule; CYP2E1

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG TOLERANCE; LD 50; LIVER CELL; LIVER TOXICITY; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ACUTE DISEASE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHRONIC DISEASE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; LIVER; MALE; METABOLISM; PATHOLOGY; TOXIC HEPATITIS;

ACUTE DISEASE; ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; CHRONIC DISEASE; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; LETHAL DOSE 50; LIVER; MALE; MICE; MICE, INBRED BALB C;

EID: 77951218280     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-009-0872-1     Document Type: Article

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