-
2
-
-
0035797529
-
Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
-
DOI 10.1056/NEJM200108023450502
-
Newman JH, Wheeler L, Lane KB et al (2001) Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 345:319-324 (Pubitemid 32703234)
-
(2001)
New England Journal of Medicine
, vol.345
, Issue.5
, pp. 319-324
-
-
Newman, J.H.1
Wheeler, L.2
Lane, K.B.3
Loyd, E.4
Gaddipati, R.5
Phillips III, J.A.6
Loyd, J.E.7
-
3
-
-
2942581061
-
Genetic basis of pulmonary arterial hypertension: Current understanding and future directions
-
Newman JH, Trembath RC, Morse JA et al (2004) Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J Am Coll Cardiol 43:S33-S39
-
(2004)
J Am Coll Cardiol
, vol.43
-
-
Newman, J.H.1
Trembath, R.C.2
Morse, J.A.3
-
4
-
-
0031019091
-
Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
-
DOI 10.1038/ng0397-277
-
Nichols WC, Koller DL, Slovis B et al (1997) Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat Genet 15:277-280 (Pubitemid 27098722)
-
(1997)
Nature Genetics
, vol.15
, Issue.3
, pp. 277-280
-
-
Nichols, W.C.1
Koller, D.L.2
Slovis, B.3
Foroud, T.4
Terry, V.H.5
Arnold, N.D.6
Siemieniak, D.R.7
Wheeler, L.8
Phillips III, J.A.9
Newman, J.H.10
Conneally, P.M.11
Ginsburg, D.12
Loyd, J.E.13
-
5
-
-
0033817459
-
Heterozygous germ-line mutations in BMPR2, encoding a TGF-b receptor, cause familial primary pulmonary hypertension
-
The International PPH Consortium
-
The International PPH Consortium, Lane KB, Machado RD, Pauciulo MW et al (2000) Heterozygous germ-line mutations in BMPR2, encoding a TGF-b receptor, cause familial primary pulmonary hypertension. Nat Genet 26:81-84
-
(2000)
Nat Genet
, vol.26
, pp. 81-84
-
-
Lane, K.B.1
MacHado, R.D.2
Pauciulo, M.W.3
-
6
-
-
0033838125
-
Familial primary pulmonary hypertension (Gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
-
DOI 10.1086/303059
-
Deng Z, Morse JH, Slager SL et al (2000) Familial primary pulmonary hypertension (Gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 67:737-744 (Pubitemid 30659603)
-
(2000)
American Journal of Human Genetics
, vol.67
, Issue.3
, pp. 737-744
-
-
Deng, Z.1
Morse, J.H.2
Slager, S.L.3
Cuervo, N.4
Moore, K.J.5
Venetos, G.6
Kalachikov, S.7
Cayanis, E.8
Fischer, S.G.9
Barst, R.J.10
Hodge, S.E.11
Knowles, J.A.12
-
7
-
-
32544458797
-
Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension
-
DOI 10.1002/humu.20285
-
Machado RD, Aldred MA, James V et al (2006) Mutations of the TGF-b type II receptor BMPR2 in pulmonary arterial hypertension. Hum Mut 27:121-132 (Pubitemid 43238027)
-
(2006)
Human Mutation
, vol.27
, Issue.2
, pp. 121-132
-
-
Machado, R.D.1
Aldred, M.A.2
James, V.3
Harrison, R.E.4
Patel, B.5
Schwalbe, E.C.6
Gruenig, E.7
Janssen, B.8
Koehler, R.9
Seeger, W.10
Eickelberg, O.11
Olschewski, H.12
Elliott, C.G.13
Glissmeyer, E.14
Carlquist, J.15
Kim, M.16
Torbicki, A.17
Fijalkowska, A.18
Szewczyk, G.19
Parma, J.20
Abramowicz, M.J.21
Galie, N.22
Morisaki, H.23
Kyotani, S.24
Nakanishi, N.25
Morisaki, T.26
Humbert, M.27
Simonneau, G.28
Sitbon, O.29
Soubrier, F.30
Coulet, F.31
Morrell, N.W.32
Trembath, R.C.33
more..
-
8
-
-
0033623296
-
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-b family
-
Thomson JR, Machado RD, Pauciulo MW et al (2000) Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-b family. J Med Genet 37:741-745
-
(2000)
J Med Genet
, vol.37
, pp. 741-745
-
-
Thomson, J.R.1
MacHado, R.D.2
Pauciulo, M.W.3
-
9
-
-
32544438253
-
BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension
-
Aldred M, Vijayakrishnan J, James V et al (2006) BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Hum Mut 27:212-213
-
(2006)
Hum Mut
, vol.27
, pp. 212-213
-
-
Aldred, M.1
Vijayakrishnan, J.2
James, V.3
-
10
-
-
16444370817
-
Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension
-
DOI 10.1097/01.GIM.0000156525.09595.E9
-
Cogan JD, Vnencak-Jones CL, Phillips JA et al (2005) Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. Genet Med 7:169-174 (Pubitemid 40478153)
-
(2005)
Genetics in Medicine
, vol.7
, Issue.3
, pp. 169-174
-
-
Cogan, J.D.1
Vnencak-Jones, C.L.2
Phillips III, J.A.3
Lane, K.B.4
Wheeler, L.A.5
Robbins, I.M.6
Garrison, G.7
Hedges, L.K.8
Loyd, J.E.9
-
11
-
-
21344455768
-
BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
-
DOI 10.1016/j.cytogfr.2005.01.009, PII S1359610105000390
-
Miyazono K, Maeda S, Imamura T. (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 16:251-263 (Pubitemid 40910315)
-
(2005)
Cytokine and Growth Factor Reviews
, vol.16
, Issue.3 SPEC. ISS.
, pp. 251-263
-
-
Miyazono, K.1
Maeda, S.2
Imamura, T.3
-
12
-
-
0032029606
-
Signal transduction by bone morphogenetic proteins
-
DOI 10.1016/S1359-6101(97)00036-1, PII S1359610197000361
-
Kawabata M, Imamura T, Miyazano K (1998) Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev 9:49-61 (Pubitemid 28280536)
-
(1998)
Cytokine and Growth Factor Reviews
, vol.9
, Issue.1
, pp. 49-61
-
-
Kawabata, M.1
Imamura, T.2
Miyazono, K.3
-
13
-
-
0034654497
-
Controlling TGF-b signaling
-
Massagué J, Chen Y-G (2000) Controlling TGF-b signaling. Genes Dev 14:627-644
-
(2000)
Genes Dev
, vol.14
, pp. 627-644
-
-
Massagué, J.1
Chen, Y.-G.2
-
14
-
-
0037204990
-
Signal transduction by the TGF-b superfamily
-
Attisano L, Wrana JL (2002) Signal transduction by the TGF-b superfamily. Science 296:1646-1647
-
(2002)
Science
, vol.296
, pp. 1646-1647
-
-
Attisano, L.1
Wrana, J.L.2
-
15
-
-
0029117276
-
Cloning and characterization of a human type II receptor for bone morphogenetic proteins
-
Rosenzweig BL, Imamura T, Okadome T et al (1995) Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A 92:7632-7636
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7632-7636
-
-
Rosenzweig, B.L.1
Imamura, T.2
Okadome, T.3
-
16
-
-
0028866028
-
Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos
-
Ishikawa T, Yoshioka H, Ohuchi H, Noji S, Nohno T (1995) Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos. Biochem Biophys Res Commun 216:26-33
-
(1995)
Biochem Biophys Res Commun
, vol.216
, pp. 26-33
-
-
Ishikawa, T.1
Yoshioka, H.2
Ohuchi, H.3
Noji, S.4
Nohno, T.5
-
17
-
-
0034972978
-
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
-
DOI 10.1038/88919
-
Howe JR, Bair JL, Sayed MG et al (2001) Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet 28:184-187 (Pubitemid 32538067)
-
(2001)
Nature Genetics
, vol.28
, Issue.2
, pp. 184-187
-
-
Howe, J.R.1
Bair, J.L.2
Sayed, M.G.3
Anderson, M.E.4
Mitros, F.A.5
Petersen, G.M.6
Velculescu, V.E.7
Traverso, G.8
Vogelstein, B.9
-
18
-
-
0142027776
-
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2
-
DOI 10.1073/pnas.2133476100
-
Lehmann K, Seemann P, Stricker S et al (2003) Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci U S A 100:12277-12282 (Pubitemid 37271551)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.21
, pp. 12277-12282
-
-
Lehmann, K.1
Seemann, P.2
Stricker, S.3
Sammar, M.4
Meyer, B.5
Suring, K.6
Majewski, F.7
Tinschert, S.8
Grzeschik, K.-H.9
Muller, D.10
Knaus, P.11
Nurnberg, P.12
Mundlos, S.13
-
19
-
-
20344385511
-
A single residue of GDF-5 defines binding specificity to BMP receptor IB
-
DOI 10.1016/j.jmb.2005.04.015, PII S0022283605004146
-
Nickel J, Kotzsch A, Sebald W, Mueller TD (2005) A single residue of GDF-5 defines binding specificity to BMP receptor IB. J Mol Biol 349:933-947 (Pubitemid 40779617)
-
(2005)
Journal of Molecular Biology
, vol.349
, Issue.5
, pp. 933-947
-
-
Nickel, J.1
Kotzsch, A.2
Sebald, W.3
Mueller, T.D.4
-
20
-
-
33847369980
-
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
-
DOI 10.1182/blood-2006-07-034124
-
David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S (2007) Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 109:1953-1961 (Pubitemid 46348192)
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 1953-1961
-
-
David, L.1
Mallet, C.2
Mazerbourg, S.3
Feige, J.-J.4
Bailly, S.5
-
21
-
-
42549158413
-
Bone morphogenetic protein-9 is a circulating vascular quiescence factor
-
DOI 10.1161/CIRCRESAHA.107.165530
-
David L, Mallet C, Keramidas M et al (2008) Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ Res 102:914-922 (Pubitemid 351591550)
-
(2008)
Circulation Research
, vol.102
, Issue.8
, pp. 914-922
-
-
David, L.1
Mallet, C.2
Keramidas, M.3
Lamande, N.4
Gasc, J.-M.5
Dupuis-Girod, S.6
Plauchu, H.7
Feige, J.-J.8
Bailly, S.9
-
23
-
-
1642459478
-
Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
-
2 30-2
-
Shi W, Chen H, Sun J, Chen C, Zhao J, Wang YL et al (2004) Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol 286:L293-L300 (Pubitemid 38129510)
-
(2004)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.286
-
-
Shi, W.1
Chen, H.2
Sun, J.3
Chen, C.4
Zhao, J.5
Wang, Y.-L.6
Anderson, K.D.7
Warburton, D.8
-
24
-
-
33644996932
-
Identification of phosphatases for Smad in the BMP/ DPP pathway
-
Chen HB, Shen J, Ip YT, Xu L (2006) Identification of phosphatases for Smad in the BMP/ DPP pathway. Genes Dev 20:648-653
-
(2006)
Genes Dev
, vol.20
, pp. 648-653
-
-
Chen, H.B.1
Shen, J.2
Ip, Y.T.3
Xu, L.4
-
25
-
-
0346996450
-
Signal transduction of bone morphogenetic protein receptors
-
DOI 10.1016/j.cellsig.2003.08.011
-
Nohe A, Keating E, Knaus P, Petersen NO (2004) Signal transduction of bone morphogenetic protein receptors. Cell Signal 16:291-299 (Pubitemid 37542404)
-
(2004)
Cellular Signalling
, vol.16
, Issue.3
, pp. 291-299
-
-
Nohe, A.1
Keating, E.2
Knaus, P.3
Petersen, N.O.4
-
26
-
-
0347991862
-
Integration of Smad and MAPK pathways: A link and a linker revisited
-
DOI 10.1101/gad.1167003
-
Massagué J (2003) Integration of Smad and MAPK pathways: a link and a linker revisited. Genes Dev 17:2993-2997 (Pubitemid 38040762)
-
(2003)
Genes and Development
, vol.17
, Issue.24
, pp. 2993-2997
-
-
Massague, J.1
-
27
-
-
0036301992
-
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
-
DOI 10.1038/ncb812
-
Grimm OH, Gurdon JB (2002) Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat Cell Biol 4:519-522 (Pubitemid 34752438)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.7
, pp. 519-522
-
-
Grimm, O.H.1
Gurdon, J.B.2
-
28
-
-
0030773834
-
Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
-
DOI 10.1038/39348
-
Kretzschmar M, Doody J, Massagu J (1997) Opposing BMP and EGF signalling pathways converge on the TGF-b family mediator Smad1. Nature 389:618-622 (Pubitemid 27446181)
-
(1997)
Nature
, vol.389
, Issue.6651
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massague, J.3
-
29
-
-
0037096836
-
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension
-
Rudarakanchana N, Flanagan JA, Chen H et al (2002) Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum Mol Genet 11:1517-1525 (Pubitemid 34679252)
-
(2002)
Human Molecular Genetics
, vol.11
, Issue.13
, pp. 1517-1525
-
-
Rudarakanchana, N.1
Flanagan, J.A.2
Chen, H.3
Upton, P.D.4
Machado, R.5
Patel, D.6
Trembath, R.C.7
Morrell, N.W.8
-
30
-
-
0036735752
-
Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension
-
DOI 10.1091/mbc.E02-02-0063
-
Nishihara A, Watabe T, Imamura T, Miyazono K (2002) Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell 13:3055-3063 (Pubitemid 35034245)
-
(2002)
Molecular Biology of the Cell
, vol.13
, Issue.9
, pp. 3055-3063
-
-
Nishihara, A.1
Watabe, T.2
Imamura, T.3
Miyazono, K.4
-
31
-
-
53349173222
-
Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: Potential for rescue
-
Sobolewski A, Rudarakanchana N, Upton PD et al (2008) Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue. Hum Mol Genet 17:3180-3190
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3180-3190
-
-
Sobolewski, A.1
Rudarakanchana, N.2
Upton, P.D.3
-
32
-
-
21644447416
-
Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary Artery smooth muscle cells
-
DOI 10.1074/jbc.M502825200
-
Yu PB, Beppu H, Kawai N, Li E, Bloch KD (2005) Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem 280:24443-24450 (Pubitemid 40934529)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.26
, pp. 24443-24450
-
-
Yu, P.B.1
Beppu, H.2
Kawai, N.3
Li, E.4
Blocht, K.D.5
-
33
-
-
33645751955
-
Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
-
Long L, MacLean MR, Jeffery TK et al (2006) Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res 98:818-827
-
(2006)
Circ Res
, vol.98
, pp. 818-827
-
-
Long, L.1
MacLean, M.R.2
Jeffery, T.K.3
-
34
-
-
0035859940
-
1 and bone morphogenetic proteins
-
Morrell NW, Yang X, Upton PD et al (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-b1 and bone morphogenetic proteins. Circulation 104:790-795 (Pubitemid 32762677)
-
(2001)
Circulation
, vol.104
, Issue.7
, pp. 790-795
-
-
Morrell, N.W.1
Yang, X.2
Upton, P.D.3
Jourdan, K.B.4
Morgan, N.5
Sheares, K.K.6
Trembath, R.C.7
-
35
-
-
0037007226
-
Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
-
DOI 10.1093/emboj/21.7.1743
-
Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P (2002) Balancing the activation status of the endothelium via two distinct TGF-b receptors. EMBO J 21:1743-1753 (Pubitemid 34614630)
-
(2002)
EMBO Journal
, vol.21
, Issue.7
, pp. 1743-1753
-
-
Goumans, M.-J.1
Valdimarsdottir, G.2
Itoh, S.3
Rosendahl, A.4
Sideras, P.5
Ten Dijke, P.6
-
36
-
-
0242330126
-
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling
-
DOI 10.1016/S1097-2765(03)00386-1
-
Goumans MJ, Valdimarsdottir G, Itoh S et al (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFb/ALK5 signaling. Mol Cell 12:817-828 (Pubitemid 37352776)
-
(2003)
Molecular Cell
, vol.12
, Issue.4
, pp. 817-828
-
-
Goumans, M.-J.1
Valdimarsdottir, G.2
Itoh, S.3
Lebrin, F.4
Larsson, J.5
Mummery, C.6
Karlsson, S.7
Ten Dijke, P.8
-
37
-
-
0037423374
-
Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses
-
DOI 10.1074/jbc.M208258200
-
Itoh S, Thorikay M, Kowanetz M et al (2003) Elucidation of Smad requirement in transforming growth factor-b type I receptor-induced responses. J Biol Chem 278:3751-3761 (Pubitemid 36801101)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.6
, pp. 3751-3761
-
-
Itoh, S.1
Thorikay, M.2
Kowanetz, M.3
Moustakas, A.4
Itoh, F.5
Heldin, C.-H.6
Ten Dijke, P.7
-
38
-
-
0037046175
-
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
-
DOI 10.1161/01.CIR.0000012754.72951.3D
-
Atkinson C, Stewart S, Upton PD et al (2002) Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 105:1672-1678 (Pubitemid 34298611)
-
(2002)
Circulation
, vol.105
, Issue.14
, pp. 1672-1678
-
-
Atkinson, C.1
Stewart, S.2
Upton, P.D.3
Machado, R.4
Thomson, J.R.5
Trembath, R.C.6
Morrell, N.W.7
-
39
-
-
0037421604
-
Signaling molecules in nonfamilial pulmonary hypertension
-
DOI 10.1056/NEJMoa021650
-
Du L, Sullivan CC, Chu D et al (2003) Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med 348:500-509 (Pubitemid 36159885)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.6
, pp. 500-509
-
-
Du, L.1
Sullivan, C.C.2
Chu, D.3
Cho, A.J.4
Kido, M.5
Wolf, P.L.6
Yuan, J.X.-J.7
Deutsch, R.8
Jamieson, S.W.9
Thistlethwaite, P.A.10
-
40
-
-
30144435554
-
HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells
-
Caldwell RL, Gadipatti R, Lane KB, Shepherd VL (2005) HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells. J Leukoc Biol 79:192-201
-
(2005)
J Leukoc Biol
, vol.79
, pp. 192-201
-
-
Caldwell, R.L.1
Gadipatti, R.2
Lane, K.B.3
Shepherd, V.L.4
-
41
-
-
28144440031
-
Simvastatin enhances bone morphogenetic protein receptor type II expression
-
DOI 10.1016/j.bbrc.2005.10.187, PII S0006291X05024873
-
Hu H, Sung A, Zhao G et al (2006) Simvastatin enhances bone morphogenetic protein receptor type II expression. Biochem Biophys Res Commun 339:59-64 (Pubitemid 41697514)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.339
, Issue.1
, pp. 59-64
-
-
Hu, H.1
Sung, A.2
Zhao, G.3
Shi, L.4
Qiu, D.5
Nishimura, T.6
Kao, P.N.7
-
42
-
-
20344362689
-
Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension
-
DOI 10.1161/01.RES.0000166926.54293.68
-
Yang X, Long L, Southwood M et al (2005) Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 96:1053-1063 (Pubitemid 40791377)
-
(2005)
Circulation Research
, vol.96
, Issue.10
, pp. 1053-1063
-
-
Yang, X.1
Long, L.2
Southwood, M.3
Rudarakanchana, N.4
Upton, P.D.5
Jeffery, T.K.6
Atkinson, C.7
Chen, H.8
Trembath, R.C.9
Morrell, N.W.10
-
43
-
-
28144460799
-
Prevention of pulmonary vascular remodeling and of decreased BMPR-2 expression by losartan therapy in shunt-induced pulmonary hypertension
-
6 58-6, DOI 10.1152/ajpheart.00518.2005
-
Rondelet B, Kerbaul F, Van Beneden R et al (2005) Prevention of pulmonary vascular remodeling and of decreased BMPR-2 expression by losartan therapy in shunt-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 289:H2319-H2324 (Pubitemid 41698538)
-
(2005)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.289
-
-
Rondelet, B.1
Kerbaul, F.2
Van Beneden, R.3
Hubloue, I.4
Huez, S.5
Fesler, P.6
Remmelink, M.7
Brimioulle, S.8
Salmon, I.9
Naeije, R.10
-
44
-
-
33644958041
-
Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension
-
DOI 10.1152/ajplung.00206.2005
-
Takahashi H, Goto N, Kojima Y et al (2006) Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 290:L450-L458 (Pubitemid 43725089)
-
(2006)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.290
, Issue.3
-
-
Takahashi, H.1
Goto, N.2
Kojima, Y.3
Tsuda, Y.4
Morio, Y.5
Muramatsu, M.6
Fukuchi, Y.7
-
45
-
-
10644256482
-
Impaired transforming growth factor-β signaling in idiopathic pulmonary arterial hypertension
-
DOI 10.1164/rccm.200311-1602OC
-
Richter A, Yeager ME, Zaiman A, Cool CD, Voelkel NF, Tuder RM (2004) Impaired transforming growth factor-b signaling in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 170:1340-1348 (Pubitemid 39657199)
-
(2004)
American Journal of Respiratory and Critical Care Medicine
, vol.170
, Issue.12
, pp. 1340-1348
-
-
Richter, A.1
Yeager, M.E.2
Zaiman, A.3
Cool, C.D.4
Voelkel, N.F.5
Tuder, R.M.6
-
46
-
-
0028308114
-
Vascular remodeling in primary pulmonary hypertension: Potential role for transforming growth factor-β
-
Botney MD, Bahadori L, Gold LI (1994) Vascular remodelling in primary pulmonary hypertension: potential role for transforming growth factor-beta. Am J Pathol 144:286-295 (Pubitemid 24165949)
-
(1994)
American Journal of Pathology
, vol.144
, Issue.2
, pp. 286-295
-
-
Botney, M.D.1
Bahadori, L.2
Gold, L.I.3
-
47
-
-
17944386754
-
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells
-
3 29-3
-
Zhang S, Fantozzi I, Tigno DD et al (2003) Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 285:L740-L754 (Pubitemid 37022876)
-
(2003)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.285
-
-
Zhang, S.1
Fantozzi, I.2
Tigno, D.D.3
Yi, E.S.4
Platoshyn, O.5
Thistlethwaite, P.A.6
Kriett, J.M.7
Yung, G.8
Rubin, L.J.9
Yuan, J.X.-J.10
-
48
-
-
45149132191
-
Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: Implications for familial pulmonary arterial hypertension
-
Yang J, Davies RJ, Southwood M et al (2008) Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension. Circ Res 102:1212-1221
-
(2008)
Circ Res
, vol.102
, pp. 1212-1221
-
-
Yang, J.1
Davies, R.J.2
Southwood, M.3
-
49
-
-
0037159280
-
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
-
DOI 10.1161/01.CIR.0000033830.36431.46
-
Valdimarsdottir G, Goumans MJ, Rosendahl A et al (2002) Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic proteininduced activation of endothelial cells. Circulation 106:2263-2270 (Pubitemid 35222223)
-
(2002)
Circulation
, vol.106
, Issue.17
, pp. 2263-2270
-
-
Valdimarsdottir, G.1
Goumans, M.-J.2
Rosendahl, A.3
Brugman, M.4
Itoh, S.5
Lebrin, F.6
Sideras, P.7
Ten Dijke, P.8
-
50
-
-
33644865928
-
Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
-
Teichert-Kuliszewska K, Kutryk MJB, Kuliszewski MA et al (2006) Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res 98:209-217
-
(2006)
Circ Res
, vol.98
, pp. 209-217
-
-
Teichert-Kuliszewska, K.1
Mjb, K.2
Kuliszewski, M.A.3
-
51
-
-
0034193390
-
BMP type II receptor is required for gastrulation and early development of mouse embryos
-
DOI 10.1006/dbio.2000.9670
-
Beppu H, Kawabata M, Hamamoto T et al (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol 221:249-258 (Pubitemid 30253588)
-
(2000)
Developmental Biology
, vol.221
, Issue.1
, pp. 249-258
-
-
Beppu, H.1
Kawabata, M.2
Hamamoto, T.3
Chytil, A.4
Minowa, O.5
Noda, T.6
Miyazono, K.7
-
52
-
-
0032960886
-
Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
-
Yang X, Castilla LH, Xin X et al (1999) Angiogenesis defects and mesenchymal apoptosis in mice lacking smad5. Development 126:1571-1580 (Pubitemid 29204322)
-
(1999)
Development
, vol.126
, Issue.8
, pp. 1571-1580
-
-
Yang, X.1
Castilla, L.H.2
Xu, X.3
Li, C.4
Gotay, J.5
Weinstein, M.6
Liu, P.P.7
Deng, C.-X.8
-
53
-
-
8644256840
-
BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
-
6 31-6, DOI 10.1152/ajplung.00239.2004
-
Beppu H, Ichinose F, Kawai N et al (2004) BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol 287:L1241-L1247 (Pubitemid 39507203)
-
(2004)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.287
-
-
Beppu, H.1
Ichinose, F.2
Kawai, N.3
Jones, R.C.4
Yu, P.B.5
Zapol, W.M.6
Miyazono, K.7
Li, E.8
Bloch, K.D.9
-
54
-
-
23044504042
-
Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
-
DOI 10.1161/CIRCULATIONAHA.104.492488
-
Song Y, Jones JE, Beppu H, Keaney JF Jr, Loscalzo J, Zhang YY (2005) Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112:553-562 (Pubitemid 41060796)
-
(2005)
Circulation
, vol.112
, Issue.4
, pp. 553-562
-
-
Song, Y.1
Jones, J.E.2
Beppu, H.3
Keaney Jr., J.F.4
Loscalzo, J.5
Zhang, Y.-Y.6
-
55
-
-
0033587156
-
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
-
DOI 10.1038/sj.onc.1202642
-
Miyaki M, Iijima T, Konishi M et al (1999) Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 18:3098-3103 (Pubitemid 29261230)
-
(1999)
Oncogene
, vol.18
, Issue.20
, pp. 3098-3103
-
-
Miyaki, M.1
Iijima, T.2
Konishi, M.3
Sakai, K.4
Ishii, A.5
Yasuno, M.6
Hishima, T.7
Koike, M.8
Shitara, N.9
Iwama, T.10
Utsunomiya, J.11
Kuroki, T.12
Mori, T.13
-
56
-
-
2342486700
-
Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle
-
DOI 10.1161/01.RES.0000126047.82846.20
-
West J, Fagan K, Steudel W et al (2004) Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 94:1109-1114 (Pubitemid 38579706)
-
(2004)
Circulation Research
, vol.94
, Issue.8
, pp. 1109-1114
-
-
West, J.1
Fagan, K.2
Steudel, W.3
Fouty, B.4
Lane, K.5
Harral, J.6
Hoedt-Miller, M.7
Tada, Y.8
Ozimek, J.9
Tuder, R.10
Rodman, D.M.11
-
57
-
-
0037235556
-
BMP signaling is required for septation of the outflow tract of the mammalian heart
-
DOI 10.1242/dev.00181
-
Delot EC, Bahamonde ME, Zhao M, Lyons KM (2003) BMP signaling is required for septation of the outflow tract of the mammalian heart. Development 130:209-220 (Pubitemid 36113956)
-
(2003)
Development
, vol.130
, Issue.1
, pp. 209-220
-
-
Delot, E.C.1
Bahamonde, M.E.2
Zhao, M.3
Lyons, K.M.4
-
58
-
-
4544386270
-
BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease
-
DOI 10.1183/09031936.04.00018604
-
Roberts KE, McElroy JJ, Wong WPK et al (2004) BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease. Eur Respir J 24:371-374 (Pubitemid 39232257)
-
(2004)
European Respiratory Journal
, vol.24
, Issue.3
, pp. 371-374
-
-
Roberts, K.E.1
McElroy, J.J.2
Wong, W.P.K.3
Yen, E.4
Widlitz, A.5
Barst, R.J.6
Knowles, J.A.7
Morse, J.H.8
-
59
-
-
50349096148
-
Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
-
Hong K-H, Lee YJ, Lee E et al (2008) Genetic ablation of the Bmpr2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation 118:722-730
-
(2008)
Circulation
, vol.118
, pp. 722-730
-
-
Hong, K.-H.1
Lee, Y.J.2
Lee, E.3
-
60
-
-
34247198299
-
Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension
-
DOI 10.1152/ajplung.00309.2006
-
McMurtry MS, Moudgil R, Hashimoto K, Bonnet S, Michelakis ED, Archer SL (2007) Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 292:L872-L878 (Pubitemid 46608233)
-
(2007)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.292
, Issue.4
-
-
McMurtry, M.S.1
Moudgil, R.2
Hashimoto, K.3
Bonnet, S.4
Michelakis, E.D.5
Archer, S.L.6
-
61
-
-
34447570591
-
Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension
-
DOI 10.1152/ajplung.00020.2006
-
Reynolds AM, Xia W, Holmes MD et al (2007) Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 292:L1182-L1192 (Pubitemid 47084862)
-
(2007)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.292
, Issue.5
-
-
Reynolds, A.M.1
Xia, W.2
Holmes, M.D.3
Hodge, S.J.4
Danilov, S.5
Curiel, D.T.6
Morrell, N.W.7
Reynolds, P.N.8
-
62
-
-
0032924166
-
BMP-2 gene expression and effects on human vascular smooth muscle cells
-
DOI 10.1159/000025634
-
Willette RN, Gu JL, Lysko PG, Anderson KM, Minehart H, Yue T (1999) BMP-2 gene expression and effects on human vascular smooth muscle cells. J Vasc Res 36:120-125 (Pubitemid 29210918)
-
(1999)
Journal of Vascular Research
, vol.36
, Issue.2
, pp. 120-125
-
-
Willette, R.N.1
Gu, J.L.2
Lysko, P.G.3
Anderson, K.M.4
Minehart, H.5
Yue, T.-L.6
-
63
-
-
0031470417
-
Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2
-
Nakaoka T, Gonda K, Ogita T et al (1997) Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2. J Clin Invest 100:2824-2832 (Pubitemid 28007552)
-
(1997)
Journal of Clinical Investigation
, vol.100
, Issue.11
, pp. 2824-2832
-
-
Nakaoka, T.1
Gonda, K.2
Ogita, T.3
Otawara-Hamamoto, Y.4
Okabe, F.5
Kira, Y.6
Harii, K.7
Miyazono, K.8
Takuwa, Y.9
Fujita, T.10
-
64
-
-
0038717407
-
BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
-
DOI 10.1038/nm888
-
Zeisberg M, Hanai Ji, Sugimoto H et al (2003) BMP-7 counteracts TGF-b1-induced epithelialto- mesenchymal transition and reverses chronic renal injury. Nat Med 9:964-968 (Pubitemid 36889942)
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 964-968
-
-
Zeisberg, M.1
Hanai, J.-I.2
Sugimoto, H.3
Mammoto, T.4
Charytan, D.5
Strutz, F.6
Kalluri, R.7
-
65
-
-
0035651361
-
Bone morphogenetic protein- 7 improves renal fibrosis and accelerates the return of renal function
-
Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S (2002) Bone morphogenetic protein- 7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13:S14-S21
-
(2002)
J Am Soc Nephrol
, vol.13
-
-
Morrissey, J.1
Hruska, K.2
Guo, G.3
Wang, S.4
Chen, Q.5
Klahr, S.6
-
66
-
-
33644831172
-
Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice
-
Saika S, Ikeda K, Yamanaka O et al (2006) Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice. Am J Physiol Cell Physiol 290:C282-C289
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
Saika, S.1
Ikeda, K.2
Yamanaka, O.3
-
67
-
-
0346096906
-
BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells
-
1 30-1
-
Buckley S, Shi W, Driscoll B, Ferrario A, Anderson K, Warburton D (2004) BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells. Am J Physiol Lung Cell Mol Physiol 286:L81-L86 (Pubitemid 38055861)
-
(2004)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.286
-
-
Buckley, S.1
Shi, W.2
Driscoll, B.3
Ferrario, A.4
Anderson, K.5
Warburton, D.6
-
68
-
-
1342270006
-
The molecular genetics of lung morphogenesis and injury repair
-
Warburton D, Bellusci S (2004) The molecular genetics of lung morphogenesis and injury repair. Paediatr Respir Rev 5:S283-S287
-
(2004)
Paediatr Respir Rev
, vol.5
-
-
Warburton, D.1
Bellusci, S.2
-
69
-
-
79959548206
-
Altered BMP/TGF-b signaling in rat models of pulmonary hypertension: Potential for ALK-5 inhibition in prevention and progression of disease
-
in press
-
Long L, Crosby AC, Yang X et al (2009) Altered BMP/TGF-b signaling in rat models of pulmonary hypertension: potential for ALK-5 inhibition in prevention and progression of disease. Circulation (in press)
-
(2009)
Circulation
-
-
Long, L.1
Crosby, A.C.2
Yang, X.3
|