Toll-like receptors involved in the pathogenesis of experimental Candida albicans keratitis

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 4, 2010, Pages 2094-2100

  Yuan, Xiaoyong ^a   Wilhelmus, Kirk R ^a  

^a CULLEN EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DECTIN 1; INTERLEUKIN 23; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDIASIS; CONTROLLED STUDY; CORNEA; DISEASE SEVERITY; DOWN REGULATION; FEMALE; FUNGAL GENE; GENE IDENTIFICATION; GENE LOCATION; IMMUNOHISTOCHEMISTRY; KERATOMYCOSIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TLR1 GENE; TLR13 GENE; TLR2 GENE; TLR4 GENE; TLR6 GENE; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CANDIDA ALBICANS; CORNEA ULCER; DNA MICROARRAY; FLUORESCENT ANTIBODY TECHNIQUE; FUNGAL EYE INFECTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CORNEAL ULCER; CYTOKINES; EYE INFECTIONS, FUNGAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; METALLOPROTEASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTORS;

EID: 77951212402     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4330     Document Type: Article

References (60)

1. Roach JC, Glusman G, Rowen L, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A. 2005;102:9577-9582.
2. Rodríguez-Martínez S, Cancino-Díaz ME, Jiménez-Zamudio L, García-Latorre E, Cancino-Díaz JC. TLRs and NODs mRNA expression pattern in healthy mouse eye. Br J Ophthalmol. 2005;89:904-910.
3. Johnson AC, Heinzel FP, Diaconu E, et al. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci. 2005;46:589-595.
4. Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22:240-273.
5. Kumar A, Yu FS. Toll-like receptors and corneal innate immunity. Curr Mol Med. 2006;6:327-337.
6. Chang JH, McCluskey PJ, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. Br J Ophthalmol. 2006;90:103-108.
7. Pearlman E, Johnson A, Adhikary G, et al. Toll-like receptors at the ocular surface. Ocul Surf. 2008;6:108-116.
8. Sun Y, Hise AG, Kalsow CM, Pearlman E. Staphylococcus aureusinduced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun. 2006;74: 5325-5332.
9. Li Q, Kumar A, Gui JF, Yu FS. Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2. Microb Pathog. 2008;44:426-434.
10. Huang X, Du W, McClellan SA, Barrett RP, Hazlett LD. TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2006;47:4910-4916.
11. Sun Y, Pearlman E. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009;50:1247-1254.
12. Gao JL, Wu XY. Aspergillus fumigatus activates human corneal epithelial cells via Toll-like receptors 2 and 4 (in Chinese). Zhonghua Yan Ke Za Zhi. 2006;42:628-633.
13. Jin X, Qin Q, Tu L, Zhou X, Lin Y, Qu J. Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of Fusarium solani in immortalized human corneal epithelial cells. Mol Vis. 2007;13:1953-1961.
14. Zhao J, Wu XY. Aspergillus fumigatus antigens activate immortalized human corneal epithelial cells via toll-like receptors 2 and 4. Curr Eye Res. 2008;33:447-454.
15. Guo H, Wu X, Yu FS, Zhao J. Toll-like receptor 2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu. Immunol Cell Biol. 2008;86:271-276.
16. Guo H, Wu X. Innate responses of corneal epithelial cells against Aspergillus fumigatus challenge. FEMS Immunol Med Microbiol. 2009;56:88-93.
17. Zhao J, Wu XY, Yu FS. Activation of Toll-like receptors 2 and 4 in Aspergillus fumigatus keratitis. Innate Immun. 2009;15:155-168.
18. Hu J, Wang Y, Xie L. Potential role of macrophages in experimental keratomycosis. Invest Ophthalmol Vis Sci. 2009;50:2087-2094.
19. Tarabishy AB, Aldabagh B, Sun Y, et al. MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J Immunol. 2008;181:593-600.
20. Jin X, Qin Q, Lin Z, Chen W, Qu J. Expression of toll-like receptors in the Fusarium solani infected cornea. Curr Eye Res. 2008;33: 319-324.
21. Wu TG, Wilhelmus KR, Mitchell BM. Experimental keratomycosis in a mouse model. Invest Ophthalmol Vis Sci. 2003;44:210-216.
22. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11:443-451.
23. Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999;162:3749-3752.
24. Hua X, Yuan X, Mitchell BM, Lorenz MC, O'Day DM, Wilhelmus KR. Morphogenic and genetic differences between Candida albicans strains are associated with keratomycosis virulence. Mol Vis. 2009;15:1476-1484.
25. Yuan X, Mitchell BM, Wilhelmus KR. Gene profiling and signaling pathways of Candida albicans keratitis. Mol Vis. 2008;14:1792-1798.
26. Kercher L, Wardwell SA, Wilhelmus KR, Mitchell BM. Molecular screening of donor corneas for fungi before excision. Invest Ophthalmol Vis Sci. 2001;42:2578-2583.
27. Sun RL, Jones DB, Wilhelmus KR. Clinical characteristics and outcome of Candida keratitis. Am J Ophthalmol. 2007;143:1043-1045.
28. Jackson BE, Wilhelmus KR, Mitchell BM. Genetically regulated filamentation contributes to Candida albicans virulence during corneal infection. Microb Pathog. 2007;42:88-93.
29. Romani L. Innate and acquired cellular immunity to fungi. In: Heitman J, Filler SG, Edwards JE Jr, Mitchell AP, eds. Molecular Principles of Fungal Pathogenesis. Washington, DC: ASM Press; 2006;471-486.
30. Wu TG, Keasler VV, Mitchell BM, Wilhelmus KR. Immunosuppression affects the severity of experimental Fusarium solani keratitis. J Infect Dis. 2004;190:192-198.
31. Richardson M, Rautemaa R. How the host fights against Candida infections. Front Biosci. 2009;14:4363-4375.
32. Uematsu S, Akira S. Toll-Like receptors (TLRs) and their ligands. In: Bauer S, Hartmann G, eds. Toll-like Receptors (TLRs) and Innate Immunity. Handbook of Experimental Pharmacology. Berlin: Springer; 2008;1-20.
33. Alarco AM, Marcil A, Chen J, Suter B, Thomas D, Whiteway M. Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens. J Immunol. 2004;172:5622-5628.
34. Levitz SM. Interactions of Toll-like receptors with fungi. Microbes Infect. 2004;6:1351-1355.
35. Roeder A, Kirschning CJ, Rupec RA, Schaller M, Weindl G, Korting HC. Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol. 2004;42:485-498.
36. van de Veerdonk FL, Kullberg BJ, van der Meer JW, Gow NA, Netea MG. Host-microbe interactions: innate pattern recognition of fungal pathogens. Curr Opin Microbiol. 2008;11:305-312.
37. Roeder A, Kirschning CJ, Rupec RA, Schaller M, Korting HC. Toll-like receptors and innate antifungal responses. Trends Microbiol. 2004;12:44-49.
38. Rozell B, Ljungdahl PO, Martinez P. Host-pathogen interactions and the pathological consequences of acute systemic Candida albicans infections in mice. Curr Drug Targets. 2006;7:483-494.
39. Netea MG, Van der Meer JW, Kullberg BJ. Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence. Clin Microbiol Infect. 2006;12:404-409.
40. Villamón E, Gozalbo D, Roig P, O'Connor JE, Fradelizi D, Gil ML. Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microbes Infect. 2004;6:1-7.
41. Netea MG, Ferwerda G, van der Graaf CA, Van der Meer JW, Kullberg BJ. Recognition of fungal pathogens by toll-like receptors. Curr Pharm Des. 2006;12:4195-4201.
42. Gil ML, Gozalbo D. Role of Toll-like receptors in systemic Candida albicans infections. Front Biosci. 2009;14:570-582.
43. Blasi E, Mucci A, Neglia R, et al. Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans. FEMS Immunol Med Microbiol. 2005;44:69-79.
44. Netea MG, van der Meer JW, Kullberg BJ. Both TLR2 and TLR4 are involved in the recognition of Candida albicans. Microbes Infect. 2006;8:2821-2822.
45. Netea MG, van de Veerdonk F, Verschueren I, van der Meer JW, Kullberg BJ. Role of TLR1 and TLR6 in the host defense against disseminated candidiasis. FEMS Immunol Med Microbiol. 2008; 52:118-123.
46. Gil ML, Gozalbo D. TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae. Microbes Infect. 2006;8:2299-2304.
47. Li M, Chen Q, Shen Y, Liu W. Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2. Exp Dermatol. 2009;18:603-610.
48. Mishra BB, Gundra UM, Teale JM. Expression and distribution of Toll-like receptors 11-13 in the brain during murine neurocysticercosis. J Neuroinflammation. 2008;5:53.
49. Kukavica-Ibrulj I, Hamelin ME, Prince GA, et al. Infection with human metapneumovirus predisposes mice to severe pneumococcal pneumonia. J Virol. 2009;83:1341-1349.
50. Shi Z, Cai Z, Wen S, et al. Transcriptional regulation of the novel toll-like receptor TLR13. J Biol Chem. 2009;284:20540-20547.
51. Goodridge HS, Underhill DM. Fungal recognition by TLR2 and dectin-1. In: Bauer S, Hartmann G, eds. Toll-like Receptors (TLRs) and Innate Immunity. Handbook of Experimental Pharmacology. Berlin: Springer; 2008;87-109.
52. Kimberg M, Brown GD. Dectin-1 and its role in antifungal immunity. Med Mycol. 2008;46:631-636.
53. Dennehy KM, Willment JA, Williams DL, Brown GD. Reciprocal regulation of IL-23 and IL-12 following co-activation of dectin-1 and TLR signaling pathways. Eur J Immunol. 2009;39:1379-1386.
54. Yuan X, Mitchell BM, Wilhelmus KR. Expression of matrix metalloproteinases during experimental Candida albicans keratitis. Invest Ophthalmol Vis Sci. 2009;50:737-742.
55. Murciano C, Yáñez A, Gil ML, Gozalbo D. Both viable and killed Candida albicans cells induce in vitro production of TNF-α and IFN-γ in murine cells through a TLR2-dependent signalling. Eur Cytokine Netw. 2007;18:38-43.
56. Zelante T, Montagnoli C, Bozza S, et al. Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi. Adv Exp Med Biol. 2007;590:209-221.
57. Yuan X, Hua X, Wilhelmus KR. Proinflammatory chemokines during Candida albicans keratitis. Exp Eye Res. In press.
58. Zhang S, Li J, Jia X, Wu Y. The expression of toll-like receptor 2 and 4 mRNA in local tissues of model of oropharyngeal candidiasis in mice. J Huazhong Univ Sci Technolog Med Sci. 2004;24:639-641.
59. Woehrle T, Du W, Goetz A, et al. Pathogen specific cytokine release reveals an effect of TLR2 Arg753Gln during Candida sepsis in humans. Cytokine. 2008;41:322-329.
60. Hong-Geller E, Chaudhary A, Lauer S. Targeting toll-like receptor signaling pathways for design of novel immune therapeutics. Curr Drug Discov Technol. 2008;5:29-38.