Organohalogens in a whale-blubber-supplemented diet affects hepatic retinol and renal tocopherol concentrations in greenland sled dogs (Canis familiaris)

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 12, 2010, Pages 773-786

  Kirkegaard, Maja ^a,b   Sonne, Christian ^b   Jakobsen, Jette ^c   Jenssen, Bjørn Munro ^d   Letcher, Robert J ^e   Dietz, Rune ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b NATIONAL ENVIRONMENTAL RESEARCH INSTITUTE   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e CARLETON UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; ALPHA TOCOPHEROL; CHLORDANE; DIELDRIN; LIPID; ORGANOHALOGEN DERIVATIVE; POLYBROMINATED DIPHENYL ETHER; POLYCHLORINATED BIPHENYL; RETINOL; UNSATURATED FATTY ACID;

ANIMAL TISSUE; ARTICLE; BALAENOPTERA; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIETARY INTAKE; DOG; DRUG EXPOSURE; DRUG LIVER LEVEL; ENVIRONMENTAL EXPOSURE; FEMALE; KIDNEY; LIVER; MALE; MINKE WHALE; NONHUMAN; PLASMA; PREDATOR; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL;

ADIPOSE TISSUE; ANIMAL FEED; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; DIETARY SUPPLEMENTS; DOGS; FEMALE; HYDROCARBONS, CHLORINATED; KIDNEY; LIVER; MALE; MATERNAL EXPOSURE; MINKE WHALE; ORGANIC CHEMICALS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; VITAMIN A; VITAMIN E;

ANIMALIA; BALAENOPTERA; BALAENOPTERA ACUTOROSTRATA; CANIDAE; CANIS FAMILIARIS; CETACEA; SUS;

EID: 77951211811     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287391003689192     Document Type: Article

References (67)

1. Banudevi, S., Krishnamoorthy, G., Venkataraman, P., Vignesh, C., Aruldhas, M. M., and Arunakaran J. 2006. Role of a-a-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food. Chem. Toxicol. 44:2040-2046. (Pubitemid 44537562)
2. Bernhoft, A., Wiig, O., and Skaare, J. U. 1997. Organochlorines in polar bears (Ursus maritimus) at Svalbard. Environ. Pollut. 95:159-175. (Pubitemid 27197134)
3. Blomhoff, R., Green, M. H., Green, J. B., Berg, T., and Norum, K. R. 1991. Vitamin A metabolism: New perspectives on absorbation, transport, and storage. Physiol. Rev. 71:951-990.
4. Braathen, M., Derocher, A.E., Wiig, ø., Sørmo, E. G., Lie, E., Skaare, J. U., and Jenssen, B. M. 2004. Relationships between PCBs and thyroid hormones and retinol in female and male polar bears. Environ. Health Perspect. 112:826-833. (Pubitemid 38811923)
5. Brouwer, A., and Van den Berg, K. J. 1986. Binding of a metabolite of 3,4,39,49-tetrachloro-biphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Toxicol. Appl. Pharmacol. 85:301-312. (Pubitemid 16026672)
6. Brouwer, A., Reijnders, P. J., and Keoman, J. H. 1989. Polychlorinated biphenyl (PCB)-contaminated fish induces vitamin A and thyroid hormone deficiency in the common seal (Phoca vitulina). Aquat. Toxicol. 15:99-106. (Pubitemid 19178547)
7. Chen, L.-C., Berberian, I., Koch, B., Mercier, M., Azais-Braesco, V., Glauert, H. P., Chow, C. K., and Robertson, L. W. 1992. Polychlorinated and polybrominated biphenyl congeners and retinoid levels in rat tissues: Structure-activity relationships. Toxicol. Appl. Pharmacol. 114:47-55.
8. Debier, C., Pomeroy, P. P., VanWouwe, N., Mingolet, E., Baret, P. V., and Larondelle, Y. 2002. Dynamics of vitamin A in grey seal (Halichoerus grypus) mothers and pups throughout lacatation. Can. J. Zool. 80: 1262-1273. (Pubitemid 36092981)
9. Debier, C., Pomeroy, P. P., Dupont, C., Joiris, C., Comblin, V., Le Boulengé, E., Larondelle, Y., and Thomé, J.-P. 2003. Quantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus. Mar. Ecol. Prog. Ser. 247:237-248. (Pubitemid 36229872)
10. Debier, C., Ylitalo, G. M., Weise, M., Gulland, F., Costa, D. P., Le Boeuf, B.J., de Tillesse, T., and Larondelle, Y. 2005. PCBs and DDT in the serum of juvenile California sea lions: Associations with vitamins A and E and thyroid hormones. Environ. Pollut. 134:323-332. (Pubitemid 39612467)
11. de Swart, R., Ross, P. S., Vedder, L. J., Timmerman, H. H., Heisterkamp, S., Van Loveren, H., Reijnders, P. J., and Osterhaus, A. D. 1994. Impairment of immune function in harbor seals (Phoca vitulina) feeding on fish from polluted waters. AMBIO 23:155-159. (Pubitemid 2064203)
12. de Swart, R. L., Ross, P. S., Vos, J. G., and Osterhaus, A. D. M. E. 1996. Impaired immunity in harbour seals (Phoca vitulina) exposed to bioaccumulated environmental contaminants: Review of a longterm feeding study. Environ. Heath Perspect. 104: 823-828.
13. Ellis-Hutchings, R. G., Cherr, G. N., Hanna, L. A., and Keen, C. L. 2006. Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. Toxicol. Appl. Pharmacol. 215:135-145.
14. Gebbink, W. A., Sonne, S., Dietz, R., Kirkegaard, M., Riget, F. F., Born, E. W., Muir, D. C. G., and Letcher, R. J. 2008a. Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus). Environ. Pollut. 152:621-629. (Pubitemid 351447277)
15. Gebbink, W. A., Sonne, C., Dietz, R., Kirkegaard, M., Born, E. W., Muir, D. C. G., and Letcher, R. J. 2008b. Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environ. Sci. Technol. 42:752-759. (Pubitemid 351213944)
16. Geraci, J. R. 1981. Dietary disorders in marine mammals: synthesis and new findings. J. Am. Vet. Med. Assoc. 179:1183-1191.
17. Grandjean P., Bellinger, D., BergmanÅ., Cordier, S., Davey-Smith, G., Eskenazi, B., Gee, D., Gray, K., Hanson, M., van den Hazel, P., Heindel, J. J., Heinzow, B., Hertz-Picciotto, I., Hu, H., Huang, T. T.-K., Jensen, T. K., Landrigan, P. J., McMillen, C., Murata, K., Ritz, B., Schoeters, G., Skakkebæk, N. E., Staffan Skerfving, S., and Pal Weihe, P. 2007. The Faroes Statement: Human health effects of developmental exposure to chemicals in our environment. Basic Clin. Pharmacol. Toxicol. 102:73-75. (Pubitemid 351143418)
18. Hallgren, S., Sinjari, T., Hakansson, H., and Darnerud, P. O. 2001. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 75:200-208. (Pubitemid 32524349)
19. Hakansson, H., Waem, F., and Ahlborg, U. G., 1987. Effects of 2,3,7,8-tctrachlorodibenzop-dioxin (TCDD) in the lactating rat on maternal and neonatal vitamin A status. J. Nutr. 117:580-586. (Pubitemid 17075269)
20. Hakansson, H., Manzoor, E., Trossvik, C., Ahlborg, U. G., Chu, I., and Villenueve, D. 1994. Effects on tissue vitamin A levels in the rat following subchronic exposure to four individual PCB congeners (IUPAC 77, 118, 126, AND 153). Chemosphere 29:2309-2313. (Pubitemid 124010214)
21. Hoekstra, W. G. 1975. Biochemical function of selenium and its relation to vitamin E. Fed. Proc. 34:2083-2089.
22. Jenssen, B. M., Skaare, J. U., Woldstad, S., Nastad, A. T., Haugen, O., Kloven, B., and Sormo, E. G. 1995. Biomarkers in blood to assess effects of PCBs in free-living grey seal pups. In Whales, seals, fish and man, eds. A. S. Blix, L. Walloe, and ø. Ulltang, pp. 607-615. Amsterdam: Elsvier Science.
23. Jenssen, B. M., Haugen, O., Sormo, E. G., and Skaare, J. U. 2003. Negative relationship between PCBs and plasma retinol in freeranging gray seal pups (Halichoerus grypus). Environ. Res. 93:79-87. (Pubitemid 36809226)
24. Jenssen, B. M. 2006. Endocrine-disrupting chemicals and climate change: A worstcase combination for arctic marine mammals and seabirds? Environ. Health Perspect. 114:76-80.
25. Jenssen, B. M., Sørmo, E. G., Bæk, K., Bytingsvik, J., Gaustad, H., Ruus, A., and Skaare, J. U. 2007. Brominated flame retardants in North-East Atlantic marine ecosystems. Environ. Health Perspect. 115:35-41.
26. Katayama, T., Momota, Y., Watanabe, Y., and Kato, N. 1991. Elevated concentrations of alphatocopherol, ascobic acid, and serum lipid in rats fed polychlorinated biphenyls, chlorobutanol, or phenobarbital. J. Nutr. Biochem. 2:92-96.
27. Käkelä, R., Käkelä, A., Hyvärinen, H., Asikainen, J., and Dahl, S.-K. 1999. Vitamins A1 and A2 and E in minks exposed to polychlorinated biphenyls (Aroclor 1242) and copper, via diet based on freshwater or marine fish. Environ. Toxicol. Chem. 18:2595-2599. (Pubitemid 29491666)
28. Käkelä, R., Kinnunen, S., Käkelä, A., Hyvärinen, H., and Asikainen, J. 2001. Fatty acids, lipids, and cytochrome P-450 monooxygenase in hepatic microsomes of minks fed fish-based diets and exposed to Aroclor 1242. J. Toxicol. Environ. Health A 64:427-446. (Pubitemid 33022469)
29. Leiva-Presa, A., and Jenssen, B. M. 2006. Effects of p,p'-DDE on retinoid homeostasis and sex hormones of adult male European common frogs (Rana temporaria). J. Toxicol. Environ. Health A 69:2051-2062. (Pubitemid 44662383)
30. Lilienthal, H. 2000. Reduced levels of 1,25-dihydroxyvitamin D(3) in rat dams and 520 offspring after exposure to a reconstituted PCB mixture. Toxicol. Sci. 57:292-301.
31. Machlin, L. J. 1991. Handbook of vitamins. New York: Marcel Dekker.
32. Mäntylä, E., and Ahotupa, M. 1993. Polychlorinated biphenyls and naphthalenes: Longlasting induction of oxidative stress in the rat. Chemosphere 27:383-390. (Pubitemid 23201204)
33. Martin, P. A., Mayne, G. J., Bursian, S., Palace, V., and Kannan, K. 2006. Changes in thyroid and vitamin A status in mink fed polyhalogenated- aromatic-hydrocarbon contaminated carp from the Saginaw River, Michigan, USA. Environ. Res. 101:53-67.
34. McDowell, L. R., 2000. Vitamins in animal and human nutrition. Ames: Iowa State University Press.
35. Morse, D. C., and Brouwer, A. 1995. Fetal, neonatal and long-term alterations in hepatic retinoid levels following maternal polychlorinated biphenyl exposure in rats. Toxicol. Appl. Pharmacol. 131:175-182.
36. Mos, L., Tabuchi, M., Dangerfield, N., Jeffries, S. J., Koop, B. F., and Ross, P.S. 2007. Contaminant-associated disruption of vitamin A and its receptor (retinoic acid receptor a) in free-ranging harbour seals (Phoca vitulina). Aquat. Toxicol. 81:3319-3328 (Pubitemid 46273703)
37. Muir, D. C. G., Backus, S., Derocher, A. E., Dietz, R., Evans, T. J., Gabrielsen, G. W., Nagy, J., Nordstrom, R. J., Sonne, S., Stirling, I., Taylor, M. K., and Letcher, R. J. 2006. Brominated flame retardants in polar bears (Ursus maritimus) from Alaska, the Canadian Arctic, Greenland and Svalbard. Environ. Sci. Technol. 40:449-455. (Pubitemid 43134009)
38. Murvoll, K. M., Jenssen, B. M., and Skaare, J. U. 2005. Effects of pentabrominated diphenyl ether (PBDE-99) on vitamin status in domestic duck (Anas platyrhynchos) hatchlings. J. Toxicol. Environ. Health A 68:515-533.
39. Murvoll, K. M., Skaare, J. U., Anderssen, E., and Jenssen, B. M. 2006. Exposure and effects of polyhalogenated compounds in European shag (Phalacrocorax aristotelis) hatchlings from the coast of Norway. Environ. Toxicol. Chem. 25:190-198. (Pubitemid 43031218)
40. Nacka, F., Cansell, M., Meleard, P., and Combe, N., 2001. Incorporation of alpha tocopherol in marine lipid-based liposomes: In vitro and in vivo studies. Lipids 36:1313-1320. (Pubitemid 34101224)
41. Nyman, M., Koistinen, J., Fant, M. L., Vartiainen, T., and Helle, E. 2002. Current levels of DDT, PCB, and trace elements in the Baltic ringed seals (Phoca hispida baltica) and gray seals (Halichoerus grypus). Environ. Pollut. 119 :399-412 (Pubitemid 34327233)
42. Nyman, M., Bergknut, M., Fant, M.L., Raunio, H., Jestoi, M., Bengs, C., Murke, A., Koistinen, J., Backman, C., Pelkonen, O., Tysklind, M., Hirvi, T., and Helle, E. 2003. Contaminant exposure and effects in Baltic ringed and grey seals as assessed by biomarkers. Marine Environ. Res. 55:73-99. (Pubitemid 35300104)
43. Oda, H., Yamashita, K., Sasaki, S., Horio, F., and Yoshida, A. 1987. Long-term effects of dietary polychlorinated biphenyl and high level of vitamin E on ascorbic acid and lipid metabolism in rats. J. Nutr. 117:1217-1223. (Pubitemid 17156473)
44. Perneger, T. V. 1998. What's wrong with Bonferroni adjustments. Br. Med. J. 316:1236-1238.
45. Raila, J., Buchholz, I., Aupperle, H., Reila, G., Schoon, H.-A., and Schweigert, F. J. 2000 The distribution of vitamin A and retinolbinding protein in the blood plasma, urine, liver and kidneys of carnivores. Vet. Res. 31:541-551.
46. Raila, J., Radon, R., Trupschuch, A., and Schweigert, F. J. 2002. Retinol and retinyl ester responses in the blood plasma and urine of dogs after a single oral dose of vitamin A1,2. J. Nutr. 132:1673S-1675S. (Pubitemid 34602729)
47. Routti, H. Nyman, M., Backman, C., Koistinen, J., and Helle, E. 2005. Accumulation of dietary organochlorines and vitamins in Baltic seals. Mar. Environ. Res. 60:267-287. (Pubitemid 40354199)
48. Schweigert, F. J., and Bok, V. 2000. Vitamin A in blood plasma and urine of dogs is affected by the dietary level of vitamin A. Int. J. Vitam. Nutr. Res. 70:84-91. (Pubitemid 30388047)
49. Schweigert, F. J., Ryder, O. A., Rambeck, W. A., and Zucker, H. 1990. The majority of vitamin A is transported as retinyl esters in the blood of most carnivores. Comp. Biochem. Physiol. A 95:573-578. (Pubitemid 20119490)
50. Sheffy, B. E., and Schultz, R. D. 1979. Influence of vitamin E and selenium on immune response mechanisms. Fed. Proc. 38:2139-2143. (Pubitemid 9231365)
51. Skaare, J. U., Bernhoft, A., Derocher, A., Gabrielsen, G. W., Goksøyr, A., Henriksen, E., Larsen, H. J., Lie, E., and Wiig, ø. 2000. Organochlorines in top predators at Svalbard - occurrence, levels and effects. Toxicol. Lett. 112-113:103-109. (Pubitemid 30138110)
52. Skaare, J. U., Bernhoft, A., Wiig, ø., Norum, K. R., Haug, E., Eide, D. M., and Derocher, A. E. 2001. Relationships between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard. J. Toxicol. Environ. Health A 62:227-241. (Pubitemid 32171612)
53. Simms, W., and Ross, P. S. 2000. Developmental changes in circulatory vitamin A (retinol) and its transport protein in free-ranging harbour seal (Phoca vitulina) pups. Can. J. Zool. 78:1862-1868.
54. Slim, R., Toborek, M., Robertson, W., and Henning, B. 1999. Antioxidant protection against PCB mediated endothelial cell activation. Toxicol. Sci. 52:232-239. (Pubitemid 30017599)
55. Sonne, C., Dietz, R., Larsen, H. J. S., Loft, K. E., Kirkegaard, M., Letcher, R. J., Shahmiri, S., and Møller, P. 2006. Impairment of cellular immunity in West Greenland sled dogs (Canis familiaris) dietary exposed to polluted minke whale (Balaenoptera acutorostrata) blubber. Environ. Sci. Technol. 40:2056-2062.
56. Sonne, C., Leifsson, P. S., Dietz, R., Kirkegaard, M., Møller, P., Jensen, A. L., Letcher, R. J., and Shahmiri, S. 2007. Renal lesions in Greenland sled dogs (Canis familiaris) exposed to a natural dietary cocktail of persistent organic pollutants. Toxicol. Environ. Chem. 89:563-576. (Pubitemid 47038233)
57. Sonne, C., Rigét, F. F., Jensen, E.-E. B., Hyldstrup, L., Teilmann, J., Dietz, R., Kirkegaard, M., Andersen, S., Letcher, R. L., and Jakobsen, J. 2008. Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sled dogs (Canis familiaris)? Environ. Int. 34:811-820.
58. Stohs, S. J., Hassan, M. Q., and Murray, W. J. 1984. Effects of BHA, D-alpha-tocopherol and retinol acetate on TCDD-mediated changes in lipid peroxidation, glutathione peroxidase activity and survival. Xenobiotica 14:533-537.
59. Van Birgelen, A. P.,Vander Kolk, J., Fase, K. M., Bol, I., Poiger, H., Brouwer, A., and Van den Berg, M. 1994. Toxic potency of 3,30,4,40,5- pentachlorobiphenyl relative and in combination with 2,3,7,8-tetrachlorodibenzo- p-dioxin in a subchronic feeding study in the rat. Toxicol. Appl. Pharmacol. 127:209-221. (Pubitemid 24263709)
60. Van der Plas, S. A., Lutkeschipholt, I., Spenkelink, B., and Brouwer, A. 2001. Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female Sprague-Dawley rats. Toxicol. Sci. 59:92-100. (Pubitemid 32117985)
61. van der Loo, B., Labugger, R., Aebischer, C.P., Bachschmid, M., Spitzer, V., Kilo, J., Altwegg, L., Ullrich, V., and Lüscher, T. F. 2004. Age-related changes of vitamin A status. J. Cardiovasc. Pharmacol. 43:26-30. (Pubitemid 38032060)
62. Verreault, J., Muir, D. C. G., Norstrom, R. J., Stirling, I., Fisk, A. T., Gabrielsen, G. W., Derocher, A. E., Evans, T. J., Dietz, R., Sonne, S., Sandala, G. M., Gebbink, W., Riget, F. F., Born, E. W., Taylor, M. K., Nagy, J., and Letcher, R. J. 2005. Chlorinated hydrocarbon contaminants and metabolites in polar bears (Ursus maritimus) from Alaska, Canada, East Greenland, and Svalbard: 1996-2002. Sci. Total Environ. 351-352:369-390. (Pubitemid 41728441)
63. Verreault, J., Dietz, R., Sonne, C., Gebbink, W. A., Shahmiri, S., and Letcher, R. J. 2008. Comparative fate of organohalogen contaminants in two top carnivores in Greenland: Captive sled dogs and wild polar bears. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 147:306-315.
64. Verreault, J., Letcher, R. J., Sonne, C., and Dietz, R. 2009. Dietary, age and transgenerational effects on the fate of organohalogen contaminants in captive sled dogs in Greenland. Environ. Int. 35:56-62.
65. Yamamoto, K., Fukuda, N., Shroi, S., Shiotsuki, Y., Nagata, Y., Tani, T., and Sakai, T. 1994. Ameliorative effect of dietary probucol on polychlorinatd biphenyls-induced hypercholesterolemia and lipid peroxidation in the rat. Life Sci. 54:1019-1026. (Pubitemid 24110167)
66. Zar, J. H. 1984. Biostatistical analysis, 2nd ed. Englewood Cliffs, NJ: Prentice Hall.
67. Zile, M. H. 1992. Vitamin A homeostasis is endangered by environmental pollutants. Proc. Soc. Exp. Biol. Med. 201:141-153.