Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia

Infection and Immunity

Volumn 78, Issue 5, 2010, Pages 2264-2271

  Mancuso, Peter ^a   Lewis, Casey ^b   Serezani, Carlos Henrique ^b   Goel, Deepti ^a   Peters Golden, Marc ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYTOKINE; LEUKOTRIENE B4; PROTEIN P47; PROTEIN SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL THERAPY; ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; HOST RESISTANCE; IMMUNOSTIMULATION; INFECTION PREVENTION; LEUKOCYTE COUNT; LUNG CLEARANCE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BIOLOGICAL PRODUCTS; COLONY COUNT, MICROBIAL; CYTOKINES; IMMUNOLOGIC FACTORS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; LEUKOCYTE COUNT; LEUKOTRIENE B4; LUNG; MICE; MICE, KNOCKOUT; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE;

EID: 77951211374     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01323-09     Document Type: Article

References (50)

1. 4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler. Thromb. Vasc. Biol. 22:443-449.
2. Aronoff, D. M., C. Lewis, C. H. Serezani, K. A. Eaton, D. Goel, J. C. Phipps, M. Peters-Golden, and P. Mancuso. 2009. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J. Immunol. 183:2642-2649.
3. Bailie, M. B., T. J. Standiford, L. L. Laichalk, M. J. Coffey, R. M. Strieter, and M. Peters-Golden. 1996. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J. Immunol. 157:5221-5224.
4. Ballinger, M. N., L. L. Hubbard, T. R. McMillan, G. B. Toews, M. Peters-Golden, R. Paine III, and B. B. Moore. 2008. Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation. Am. J. Physiol. Lung Cell. Mol. Physiol. 295:L114-L122.
5. Balter, M., G. Toews, and M. Peters-Golden. 1989. Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages. J. Immunol. 142:602-608. (Pubitemid 19039983)
6. 4 generation in granulocytes from protein-energy malnourished chronically ill elderly. J. Intern. Med. 247:715-722.
7. Chen, X., J. Sheller, E. Johnson, and C. Funk. 1994. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 372:179-182. (Pubitemid 24347837)
8. Christensen, K. L. Y., R. C. Holman, C. A. Steiner, J. J. Sejvar, B. J. Stoll, and L. B. Schonberger. 2009. Infectious disease hospitalizations in the United States. Clin. Infect. Dis. 49:1025-1035.
9. Coffey, M. J., C. S. Wheeler, K. B. Gross, W. L. Eschenbacher, P. H. Sporn, and M. Peters-Golden. 1996. Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology 114:187-197.
10. Coffey, M. J., S. E. Wilcoxen, S. M. Phare, R. U. Simpson, M. R. Gyetko, and M. Peters-Golden. 1994. Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages from 1,25-dihydroxyvitamin D3-deficient rats. Prostaglandins 48:313-329.
11. Demitsu, T., H. Katayama, T. Saito-Taki, H. Yaoita, and M. Nakano. 1989. Phagocytosis and bactericidal action of mouse peritoneal macrophages treated with leukotriene B4. Int. J. Immunopharmacol. 11:801-808.
12. Donowitz, G. R., and H. L. Cox. 2007. Bacterial community-acquired pneumonia in older patients. Clin. Geriatr. Med. 23:515-534.
13. 4 triggers the in vitro and in vivo release of potent antimicrobial agents. J. Immunol. 178:8036-8045.
14. 4, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286:264-265.
15. Groemping, Y., and K. Rittinger. 2005. Activation and assembly of the NADPH oxidase: a structural perspective. Biochem. J. 386:401-416. (Pubitemid 40445864)
16. 4 synthesis by polymorphonuclear leukocytes from male patients with diabetes mellitus. Prostaglandins Leukot. Med. 14:305-311.
17. Koyama, S., A. Takamizawa, E. Sato, T. Masubuchi, S. Nagai, and T. Izumi. 2001. Cyclophosphamide stimulates lung fibroblasts to release neutrophil and monocyte chemoattractants. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L1203-L1211.
18. 4 in human polymorphonuclear leukocytes. Blood 93:1399-1405.
19. Mancuso, P., A. Gottschalk, S. M. Phare, M. Peters-Golden, N. W. Lukacs, and G. B. Huffnagle. 2002. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J. Immunol. 168:4018-4024. (Pubitemid 34298407)
20. Mancuso, P., G. B. Huffnagle, M. A. Olszewski, J. Phipps, and M. Peters-Golden. 2006. Leptin corrects host defense defects following acute starvation in murine pneumococcal pneumonia. Am. J. Respir. and Crit. Care Med. 173:212-218.
21. Mancuso, P., T. Marshall, T. Standiford, and M. Peters-Golden. 1998. 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Infect. Immun. 66:5140-5146.
22. 4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect. Immun. 69:2011-2016.
23. Mandell, L. A., R. G. Wunderink, A. Anzueto, J. G. Bartlett, G. D. Campbell, N. C. Dean, S. F. Dowell, T. M. File, Jr., D. M. Musher, M. S. Niederman, A. Torres, and C. G. Whitney. 2007. Infectious Diseases Society of America/ American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin. Infect. Dis. 44(Suppl. 2): S27-S72.
24. 4 in the human lung: recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J. Clin. Invest. 89:1009-1019.
25. Matsukawa, A., C. M. Hogaboam, N. W. Lukacs, P. M. Lincoln, R. M. Strieter, and S. L. Kunkel. 1999. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J. Immunol. 163:6148-6154.
26. 4 stimulates human polymorphonuclear leukocytes to synthesize and release interleukin-8 in vitro. Am. J. Respir. Cell Mol. Biol. 10:651-657.
27. Medeiros, A. I., A. Sa-Nunes, E. G. Soares, C. M. Peres, C. L. Silva, and L. H. Faccioli. 2004. Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis. Infect. Immun. 72:1637-1644.
28. Medeiros, A. I., A. Sa-Nunes, W. M. Turato, A. Secatto, F. G. Frantz, C. A. Sorgi, C. H. Serezani, G. S. Deepe, Jr., and L. H. Faccioli. 2008. Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. J. Immunol. 181:8544-8551.
29. Medeiros, A. I., C. L. Silva, A. Malheiro, C. M. L. Maffei, and L. H. Faccioli. 1999. Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the {beta}-glucan present in their cell wall. Br. J. Pharmacol. 128:1529-1537.
30. Mizgerd, J. P. 2008. Acute lower respiratory tract infection. N. Engl. J. Med. 358:716-727.
31. Mizgerd, J. P. 2006. Lung infection - a public health priority. PLoS Med. 3:e76.
32. Mueller, N. J. 2008. New immunosuppressive strategies and the risk of infection. Transpl. Infect. Dis. 10:379-384.
33. Peres, C. M., D. M. Aronoff, C. H. Serezani, N. Flamand, L. H. Faccioli, and M. Peters-Golden. 2007. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J. Immunol. 179:5454-5461.
34. Peres, C. M., L. de Paula, A. I. Medeiros, C. A. Sorgi, E. G. Soares, D. Carlos, M. Peters-Golden, C. L. Silva, and L. H. Faccioli. 2007. Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. Microbes Infect. 9:483-489.
35. Peters-Golden, M., C. Canetti, P. Mancuso, and M. J. Coffey. 2005. Leukotrienes: underappreciated mediators of innate immune responses. J. Immunol. 174:589-594. (Pubitemid 40103563)
36. Peters-Golden, M., and W. R. Henderson, Jr. 2007. Leukotrienes. N. Engl. J. Med. 357:1841-1854.
37. Pitt, J., and H. Bernheimer. 1974. Role of peroxide in phagocytic killing of pneumococci. Infect. Immun. 9:48-52.
38. 4 up-regulates IL-6 rather than IL-1 synthesis in human monocytes. Agents Actions 34:42-45.
39. Rola-Pleszczynski, M., and J. Stankova. 1992. Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Blood 80:1004-1011.
40. 4 in normal and in asthmatic subjects. Am. J. Respir. Crit. Care Med. 155:1789-1792.
41. Schultz, M. J., J. Wijnholds, M. P. Peppelenbosch, M. Vervoordeldonk, P. Speelman, S. van Deventer, P. Borst, and T. van der Poll. 2001. Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J. Immunol. 166:4059-4064.
42. Serezani, C., D. Aronoff, S. Jancar, P. Mancuso, and M. Peters-Golden. 2005. Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 106:1067-1075. (Pubitemid 41076456)
43. 4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. J. Leukoc. Biol. 78:976-984.
44. Serezani, C. H., J. H. Perrela, M. Russo, M. Peters-Golden, and S. Jancar. 2006. Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J. Immunol. 177:3201-3208.
45. Standiford, T. J., S. L. Kunkel, M. J. Greenberger, L. L. Laichalk, and R. M. Strieter. 1996. Expression and regulation of chemokines in bacterial pneumonia. J. Leukoc. Biol. 59:24-28.
46. 4 induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. Infect. Immun. 70:4247-4253.
47. Taut, K., C. Winter, D. E. Briles, J. C. Paton, J. W. Christman, R. Maus, R. Baumann, T. Welte, and U. A. Maus. 2008. Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae. Am. J. Respir. Cell Mol. Biol. 38:105-113.
48. Volovitz, B., R. C. Welliver, G. De Castro, D. A. Krystofik, and P. L. Ogra. 1988. The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr. Res. 24:504-507.
49. Winter, C., W. Herbold, R. Maus, F. Langer, D. E. Briles, J. C. Paton, T. Welte, and U. A. Maus. 2009. Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J. Immunol. 182:4931-4937.
50. Winter, C., K. Taut, M. Srivastava, F. Langer, M. Mack, D. Briles, J. Paton, R. Maus, T. Welte, M. Gunn, and U. Maus. 2007. Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J. Immunol. 178:5828-5838. (Pubitemid 46674380)