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Volumn 18, Issue 9, 2010, Pages 3212-3223
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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs
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Author keywords
Antagonist; EP3 receptor; Prostaglandin; Uterine contraction
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Indexed keywords
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(2 METHYLPHENOXY)METHYL]PHENYL]PROPANOIC ACID;
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(2 METHYLPYRIDIN 3 YLOXY)METHYL]PHENYL]PROPANOIC ACID;
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(3 FLUOROPHENOXY)METHYL]PHENYL]PROPANOIC ACID;
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(6 METHYLPYRIDIN 3 YLOXY)METHYL]PHENYL]PROPANOIC ACID;
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(PHENOXYMETHYL)]PHENYL]PROPANOIC ACID;
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(PYRIDIN 3 YLOXY)METHYL]PHENYL]PROPANOIC ACID;
3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 PHENOXYPHENYL]PROPANOIC ACID;
3 [2 HYDROXY 4 (METHOXYMETHOXY)PHENYL]METHACRYLIC ACID;
3 [2 HYDROXY 4 (METHOXYMETHOXY)PHENYL]METHYLPROPIONIC ACID;
3 [4 (3 CYANOPHENOXY) 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 (3,5 DIFLUROPHENOXY) 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(2 CHLOROPHENOXY)METHYL] 3 [2 [[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(2,4 DIFLUOROPHENOXY)METHYL] 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(2,4 DIMETHYLPHENOXY)METHYL] 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(2,5 DIFLUOROPHENOXY)METHYL] 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(2,5 DIMETHYLPHENOXY)METHYL] 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(3 CHLOROPHENOXY)METHYL] 3 [2 [[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(3 CYANOPHENOXY)METHYL] 3 [2 [[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(3,5 DIMETHYLPHENOXY)] 2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL]PHENYL]PROPANOIC ACID;
3 [4 [(3,5 DIMETHYLPHENYL)AMINO] 2 [[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUYL]CARBONYL]PHENYL]PROPANOIC ACID;
5 (METHOXYMETHOXY) 2 (3 METHOXY 3 OXOPROPYL) BENZOIC ACID;
7 (METHOXYMETHOXY) 2H CHROMEN 2 ONE;
BENZYL 2 (3 ETHOXY 3 OXOPROP1 EN 1 YL) 5 NITROBENZOIC ACID;
BENZYL 2 BROMO 5 NITROBENZOIC ACID;
METHYL 3 [2 [[[1 (3,5 DIMETHYLPHENYL) 3 METHYLBUTYL]AMINO]CARBONYL] 4 [(HYDROXYMETHYL)]PHENYL]PROPANOIC ACID;
METHYL 3 [2 HYDROXY 4 (METHOXYMETHOXY)PHENYL]PROPANOIC ACID;
PROPIONIC ACID DERIVATIVE;
PROSTAGLANDIN E RECEPTOR;
PROSTAGLANDIN RECEPTOR BLOCKING AGENT;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
AREA UNDER THE CURVE;
ARTICLE;
BINDING AFFINITY;
CONTROLLED STUDY;
DRUG BIOAVAILABILITY;
DRUG CLEARANCE;
DRUG DESIGN;
DRUG EFFICACY;
DRUG HALF LIFE;
DRUG METABOLISM;
DRUG POTENCY;
DRUG SCREENING;
DRUG SELECTIVITY;
DRUG STABILITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN TISSUE;
IN VITRO STUDY;
IN VIVO STUDY;
INHIBITION KINETICS;
LIVER MICROSOME;
MAXIMUM PLASMA CONCENTRATION;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
RAT;
RECEPTOR BINDING;
STEREOCHEMISTRY;
STRUCTURE ACTIVITY RELATION;
UTERUS CONTRACTION;
ADMINISTRATION, ORAL;
ANIMALS;
BINDING, COMPETITIVE;
CHO CELLS;
CRICETINAE;
CRICETULUS;
DRUG STABILITY;
FEMALE;
HUMANS;
MICROSOMES, LIVER;
MOLECULAR STRUCTURE;
PREGNANCY;
PREGNANCY, ANIMAL;
PROPIONIC ACIDS;
RADIOLIGAND ASSAY;
RATS;
RECEPTORS, PROSTAGLANDIN E;
RATTUS;
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EID: 77951209030
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2010.03.028 Document Type: Article |
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Times cited : (6)
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References (16)
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