Late-Onset Hemorrhagic Cystitis in Children after Hematopoietic Stem Cell Transplantation for Thalassemia and Sickle Cell Anemia: A Prospective Evaluation of Polyoma (BK) Virus Infection and Treatment with Cidofovir

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 5, 2010, Pages 662-671

  Gaziev, Javid ^a   Paba, Pierpaolo ^a   Miano, Roberto ^a   Germani, Stefano ^a   Sodani, Pietro ^a   Bove, Pierluigi ^a   Perno, Carlo Federico ^a   Marziali, Marco ^a   Gallucci, Cristiano ^a   Isgrò, Antonella ^a   Paciaroni, Katia ^a   Roveda, Andrea ^a   Simone, Maria Domenica ^a   De Angelis, Gioia ^a   Alfieri, Cecilia ^a   Lucarelli, Guido ^a  

^a TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

BK virus; Cidofovir; Hemoglobinopathies; Hemorrhagic cystitis; Stem cell transplantation

Indexed keywords

ACICLOVIR; AMPHOTERICIN B; AZATHIOPRINE; BUSULFAN; CIDOFOVIR; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; HYDROXYUREA; IMMUNOGLOBULIN; INFUSION FLUID; MESNA; METHOTREXATE; METHYLPREDNISOLONE; NYSTATIN; PAROMOMYCIN; PROBENECID; STEROID; THIOTEPA; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ARTICLE; BLOOD ANALYSIS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMORRHAGIC CYSTITIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NEPHROTOXICITY; POLYMERASE CHAIN REACTION; POLYOMA VIRUS; RISK FACTOR; SICKLE CELL ANEMIA; THALASSEMIA; TREATMENT DURATION; URINALYSIS; VIREMIA; VIRURIA; VIRUS INFECTION; VIRUS REACTIVATION;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; BK VIRUS; CHILD; CHILD, PRESCHOOL; CYSTITIS; CYTOSINE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMORRHAGE; HUMANS; INCIDENCE; INFANT; MIDDLE AGED; PHOSPHONIC ACIDS; POLYOMAVIRUS INFECTIONS; PROSPECTIVE STUDIES; THALASSEMIA; TUMOR VIRUS INFECTIONS; YOUNG ADULT;

EID: 77951208218     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.12.009     Document Type: Article

References (40)

1. Brugieres L., Hartmann O., Travagli J.P., et al. Hemorrhagic cystitis following high-dose chemotherapy and bone marrow transplantation in children with malignancies: incidence, clinical course, and outcome. J Clin Oncol 1989, 7:194-199.
2. Bedi A., Carole B.M., Hanson J.L., et al. Association of BK virus failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995, 13:1103-1109.
3. De Vries C.R., Freiha F.S. Hemorrhagic cystitis: a review. J Urol 1990, 143:1-9.
4. Kondo M., Kojima S., Kato K., et al. Late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation. Bone Marrow Transplant 1998, 22:995-998.
5. Giraud G., Priftakis P., Bogdanovic G., et al. BK viruria and hemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated HLA-mismatched grafts. Bone Marrow Transplant 2008, 41:737-742.
6. Cesaro S., Facchin C., Tridello G., et al. A prospective study of BK-virus associated hemorrhagic cystitis in paediatric patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant 2008, 41:363-370.
7. Arthur R.R., Shah K.V., Baust S.J., et al. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplantation. N Engl J Med 1986, 315:230-234.
8. Hirsch H.H., Steiger J. Polyomavirus BK. Lancet Infect Dis 2003, 3:611-623.
9. Hoffman J.A., Shah A.J., Ross L.A., et al. Adenoviral infection and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001, 7:388-394.
10. Spach D.H., Bauwens J.E., Meyerson D., et al. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993, 16:142-144.
11. Reploeg M.D., Storch G.A., Clifford D.B. BK virus: a clinical review. Clin Infect Dis 2001, 33:191-202.
12. Lin P.L., Vates A.N., Green M. BK virus infection in renal transplant recipients. Pediatr Transplant 2001, 5:398-405.
13. Priftakis P., Bogdanovic G., Kokhaei P., et al. BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist. J Clin Virol 2003, 26:71-77.
14. Apperley J.F., Rice S.J., Bishop J.A., et al. Late-onset hemorrhagic cystitis associated with urinary excretion of polyomaviruses after bone marrow transplantation. Transplantation 1987, 43:108-112.
15. Azzi A., Cesaro S., Laszlo D., et al. Human polyomavirus BK (BKV) load and hemorrhagic cystitis in bone marrow transplant recipients. J Clin Virol 1999, 14:79-86.
16. Leung A.Y.H., Seun C.K.M., Lie A.K.W., et al. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood 2001, 98:1971-1978.
17. Wong S.Y., Chan K.H., Cheng V.C.C., et al. Relationship of pretransplant polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 2007, 44:830-837.
18. Erard V., Kim H.W., Corey L., et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 2005, 106:1309-1315.
19. Andrei G., Snoeck R., Vandeputte M., et al. Activities of various compounds against murine and primate polyomaviruses. Antimicrob Agents Chemother 1997, 41:587-593.
20. Vats A., Sapiro R., Randhawa S.P., et al. Quantitative viral load monitoring and cidofovir therapy for management of BK virus-associated nephropathy in children and adults. Transplantation 2003, 75:105-112.
21. Gorczynska E., Turkiewicz D., Rybka K., et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2005, 11:797-804.
22. Savona M.R., Newton D., Frame D., et al. Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplantation. Bone Marrow Transplant 2007, 39:783-787.
23. Ishak K., Baptista A., Bianchi L., et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995, 22:696-699.
24. Gooley T.A., Leisenring W., Crowley J., et al. Estimation of failure probabilities in the presence of competing risk: new representation of old estimators. Stat Med 1999, 18:695-706.
25. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
26. Fine J.P., Gray R.J. A proportional hazard model for the subdistribution of a competing risk. J Am Stat Assoc 1999, 94:496-509.
27. R Development Core Team. R: a language and environment for statistical computing. Available from: Version 2.9.1 Accessed June 26, 2009. http://www.R-project.org.
28. Iwamoto S., Azuma E., Hori H., et al. BKV-associated fatal renal failure following late-onset hemorrhagic cystitis in unrelated bone marrow transplantation. Pediatr Hematol Oncol 2002, 19:255-261.
29. Vogel T.A., Peinemann F., Burdach S., et al. Urologic treatment and clinical course of BK polyomavirus-associated hemorrhagic cystitis in children after bone marrow transplantation. Eur Urol 1999, 36:252-257.
30. Pahari A., Rees L. BK virus-associated renal problems: clinical implications. Pediatr Nephrol 2003, 18:743-748.
31. Comoli P., Binggeli S., Ginevri F., et al. Polyomavirus-associated nephropathy: update on BK virus-specific immunity. Transplant Infect Dis 2006, 8:86-94.
32. Bogdanovic G., Priftakis P., Giraud G., et al. Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation. J Clin Microbiol 2004, 42:5394-5396.
33. Brennan D.C., Flavin K., Lowel J.A., et al. A randomized, double-blinded comparison of thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients. Transplantation 1999, 67:1011-1018.
34. Remberger M., Svahn B.M., Mattsson J., et al. Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem cell transplantation. Transplantation 2004, 78:122-127.
35. Ost L., Lonnovist B., Eriksson L., et al. Hemorrhagic cystritis: a manifestation of graft- versus-host disease?. Bone Marrow Transplant 1987, 2:19-25.
36. El-Zimaity M., Saliba R., Chan K., et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters. Blood 2004, 103:4674-4680.
37. Gaston K.E., Gabriel D.A., Lavelle J.P. Rare cause of ureteral obstruction. Urology 2005, 66:1110. e5-1110.e6.
38. Faraci M., Cuzubbo D., Lanino E., et al. Low-dose cidofovir without probenecid as treatment for BK virus hemorrhagic cystitis after hematopoietic stem cell transplantation. Pediatr Infect Dis J 2008, 28:55-57.
39. Yusuf U., Hale G.A., Carr J., et al. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation 2006, 81:1398-1404.
40. Ljungman P., Deliliers L., Platzbecker U., et al. Cidofovir for cytomegalovirus infection and disease in allogeneic stem cell transplant recipients. Blood 2009, 97:388-392.