PTX3 as a potential biomarker of acute lung injury: Supporting evidence from animal experimentation

Intensive Care Medicine

Volumn 36, Issue 2, 2010, Pages 356-364

  He, Xiaolin ^a,b   Han, Bing ^a,b   Bai, Xiaohui ^a,b   Zhang, Yu ^a,b   Cypel, Marcelo ^a,b   Mura, Marco ^a,b   Keshavjee, Shaf ^a,b   Liu, Mingyao ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Toronto Medical Discovery ^*  (Canada)

Author keywords

Acute respiratory distress syndrome; Inflammation; Pulmonary coagulopathy; Transgenic mice

Indexed keywords

LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; PENTRAXIN 3; THROMBOPLASTIN; C REACTIVE PROTEIN; NERVE PROTEIN; NEURONAL PENTRAXIN;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULANT THERAPY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC MARKER; GENETICS; LUNG LAVAGE; POLYMERASE CHAIN REACTION; SEPSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; BRONCHOALVEOLAR LAVAGE FLUID; C-REACTIVE PROTEIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC MARKERS; MICE; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS;

EID: 77951208211     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-009-1720-0     Document Type: Article

References (35)

1. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334-1349
2. Liu M (2005) Searching for acute respiratory distress syndrome genes: aren't we there yet? Am J Respir Crit Care Med 171:298-299
3. Jeyaseelan S, Chu HW, Young SK, Worthen GS (2004) Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun 72:7247-7256
4. Ye SQ, Simon BA, Maloney JP, Zambelli-Weiner A, Gao L, Grant A, Easley RB, McVerry BJ, Tuder RM, Standiford T, Brower RG, Barnes KC, Garcia JG (2005) Pre-B-cell colonyenhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med 171:361-370
5. Gao L, Flores C, Fan-Ma S, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JG (2007) Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Transl Res 150:18-29
6. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB (2008) Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol 294:L874-881
7. Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A (2006) Pentraxins as a key component of innate immunity. Curr Opin Immunol 18:10-15
8. He X, Han B, Liu M (2007) Long pentraxin 3 in pulmonary infection and acute lung injury. Am J Physiol Lung Cell Mol Physiol 292:L1039-1049
9. dos Santos CC, Han B, Andrade CF, Bai X, Uhlig S, Hubmayr R, Tsang M, Lodyga M, Keshavjee S, Slutsky AS, Liu M (2004) DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch. Physiol Genomics 19:331-342
10. Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M (2005) TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol 175:8303-8311
11. Okutani D, Han B, Mura M, Waddell TK, Keshavjee S, Liu M (2007) Highvolume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats. Am J Physiol Lung Cell Mol Physiol 292:L144-153
12. Muller B, Peri G, Doni A, Torri V, Landmann R, Bottazzi B, Mantovani A (2001) Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med 29:1404-1407
13. Mauri T, Coppadoro A, Bellani G, Bombino M, Patroniti N, Peri G, Mantovani A, Pesenti A (2008) Pentraxin 3 in acute respiratory distress syndrome: an early marker of severity. Crit Care Med 36:2302-2308
14. Cribbs SK, Martin GS (2008) Biomarkers in acute lung injury: are we making progress? Crit Care Med 36:2457-2459
15. Biomarkers Definitions Working Group (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69:89-95
16. Napoleone E, di Santo A, Peri G, Mantovani A, de Gaetano G, Donati MB, Lorenzet R (2004) The long pentraxin PTX3 up-regulates tissue factor in activated monocytes: another link between inflammation and clotting activation. J Leukoc Biol 76:203-209
17. Napoleone E, Di Santo A, Bastone A, Peri G, Mantovani A, de Gaetano G, Donati MB, Lorenzet R (2002) Long pentraxin PTX3 upregulates tissue factor expression in human endothelial cells: a novel link between vascular inflammation and clotting activation. Arterioscler Thromb Vasc Biol 22:782-787
18. Gando S, Nanzaki S, Morimoto Y, Kobayashi S, Kemmotsu O (1999) Systemic activation of tissue-factor dependent coagulation pathway in evolving acute respiratory distress syndrome in patients with trauma and sepsis. J Trauma 47:719-723
19. Welty-Wolf KE, Carraway MS, Ortel TL, Piantadosi CA (2002) Coagulation and inflammation in acute lung injury. Thromb Haemost 88:17-25
20. Bastarache JA, Ware LB, Bernard GR (2006) The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med 27:365-376
21. Hofstra JJ, Juffermans NP, Schultz MJ, Zweers MM (2008) Pulmonary coagulopathy as a new target in lung injury-A review of available pre-clinical models. Curr Med Chem 15:588-595
22. Laterre PF, Wittebole X, Dhainaut JF (2003) Anticoagulant therapy in acute lung injury. Crit Care Med 31:S329-336
23. Stahel PF, Smith WR, Moore EE (2008) Hypoxia and hypotension, the "lethal duo" in traumatic brain injury: implications for prehospital care. Intensive Care Med 34:402-404
24. Snyder LA, Rudnick KA, Tawadros R, Volk A, Tam SH, Anderson GM, Bugelski PJ, Yang J (2008) Expression of human tissue factor under the control of the mouse tissue factor promoter mediates normal hemostasis in knock-in mice. J Thromb Haemost 6:306-314
25. Perl M, Chung CS, Lomas-Neira J, Rachel TM, Biffl WL, Cioffi WG, Ayala A (2005) Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol 167:1545-1559
26. Takano H, Inoue K, Yanagisawa R, Sato M, Shimada A, Morita T, Sawada M, Nakamura K, Sanbongi C, Yoshikawa T (2004) Protective role of metallothionein in acute lung injury induced by bacterial endotoxin. Thorax 59:1057-1062
27. Mura M, Andrade CF, Han B, Seth R, Zhang Y, Bai XH, Waddell TK, Hwang D, Keshavjee S, Liu M (2007) Intestinal I/R-induced acute lung injury and oncotic cell death in multiple organs. Shock 28:227-238
28. Mura M, Han B, Andrade CF, Seth R, Hwang D, Waddell TK, Keshavjee S, Liu M (2006) The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival. Crit Care 10:R130
29. Nishina K, Mikawa K, Takao Y, Maekawa N, Shiga M, Obara H (1997) ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg 84:1097-1103
30. Singh I, Smith A, Vanzieleghem B, Collen D, Burnand K, Saint-Remy JM, Jacquemin M (2002) Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model. Blood 99:3235-3240
31. Liu M (2008) ARDS and knowledge translation. Intensive Care Med 34:589-591
32. dos Santos CC, Okutani D, Hu P, Han B, Crimi E, He X, Keshavjee S, Greenwood C, Slutsky AS, Zhang H, Liu M (2008) Differential gene profiling in acute lung injury identifies injury-specific gene expression. Crit Care Med 36:855-865
33. Chambers RC (2008) Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? Br J Pharmacol 153(Suppl 1):S367-378
34. Schultz MJ, Haitsma JJ, Zhang H, Slutsky AS (2006) Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia-a review. Crit Care Med 34:871-877
35. Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB (2007) The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax 62:608-616