Applying computational fluid dynamics technology in bioprocesses

BioPharm International

Volumn 23, Issue 4, 2010, Pages 38-45

  Fang, Zhiwu ^a  

^a Systems Quality by Design Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPROCESS; BIOREACTOR; BIOTECHNOLOGY; CASE STUDY; CELL CULTURE; CENTRIFUGATION; CHROMATOGRAPHY; COMPUTATIONAL FLUID DYNAMICS; EMULSION; FERMENTATION; FILTRATION; FLOW KINETICS; FLOW RATE; HEAT TRANSFER; LAMINAR FLOW; PARTICLE RESUSPENSION; PHASE TRANSITION; PHYSICAL MODEL; POROSITY; PROCESS OPTIMIZATION; REVIEW; TURBULENT FLOW;

EID: 77951197376     PISSN: 1542166X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Thompson TB, Kontomaris K. Technology roadmap for computational fluid dynamics. 1999. Available from: http://www.chemicalvision2020.org/cfd.html.
2. Hassan YA, Schmidl W, Ortiz-Villafuerte. Investigation of threedimensional two-phase flow structure in a bubbly pipe flow. J Meas Sci Technol. 1998; 9 (3) : 309-326. (Pubitemid 28205815)
3. Pordal HS, Matice CJ, Fry TJ. The role of computational fluid dynamics in the pharmaceutical industry. Pharm Technol. 2002; 26 (2) : 72-77.
4. Kremer DM, Hancock BC. Process simulation in the pharmaceutical industry: a review of some basic physical models. J Pharm Sci. 2006; 95 (3) : 517-529.
5. Wassgren C. The application of computational modeling to pharmaceutical materials science. MRS Bulletin. 2006; 31 (11) : 900-4. (Pubitemid 44826647)
6. Kremer DM, Hancock BC. Process simulation in the pharmaceutical industry: A review of some basic physical models. J Pharm Sci. 2006; 95 (3) : 517-29.
7. Anderson JD. Computational fluid dynamics: the basics with application. New York: McGraw Hill; 1995.
8. Derksen JJ. Numerical simulation of solid suspension in a stirred tank. AIChE J. 2003; 49: 2700-14. (Pubitemid 37444328)
9. Decker S, Sommerfeld M. Calculation of particle suspension in agitated vessels with the Eulerian-Lagrange approach. Inst Chem Eng Symp Ser. 1996; 140: 71-82.
10. Crowe CT, Sommerfeld M, Tsuji Y. Fundamentals of gas-particle and gas-droplet flows. Boca Raton: CRC Press; 1998.
11. Barrue H, Bertrand J, Cristol B, Xuereb C. Eulerian simulation of dense solid-liquid suspension in multi-stage stirred vessel. J Chem Eng Jpn. 1999; 34: 585-94. (Pubitemid 32704373)
12. Bakker A, Fasano JB, Myers KJ. Effect of flow pattern on the solids distribution in a stirred tank. 8th European Conference on Mixing, IChemE Symposium Series No. 136. 1994 Sept 21-23; Cambridge, UK.
13. Micale G, Montante G, Grisafi F, Brucato A, Godfrey J. CFD simulation of particle distribution in stirred reactors. Trans Inst Chem Eng. Part A. 2000; 78: 435-44. (Pubitemid 30354947)
14. Micale G, Girsafi F, Rizzuti L, Brucato A. CFD simulation of particle suspension height in stirred vessels. Chem Eng Res Des. 2004; 82: 1204-13. (Pubitemid 39300650)
15. Ljungqvist M, Rasmuson A. Numerical simulation of the twophase flow in an axially stirred reactor. Part A Trans Inst Chem Eng. 2001; 79: 533-46. (Pubitemid 32770658)
16. Montante G, Micale G, Magelli F, Brucato A. Experiments and CFD prediction of solid particle distribution in a reactor agitated with four pitched blade turbines. Trans Inst Chem Eng Part A. 2001; 79: 1005-10. (Pubitemid 34137704)
17. Barrue H, Bertrand J, Cristol B, Xuereb C. Eulerian simulation of dense solid-liquid suspension in multi-stage stirred vessel. J Chem Eng Jpn. 2001; 34 (5) : 585-594.
18. Jenne M, Reuss M. A critical assessment on the use of k-e turbulence models for simulation of the turbulent liquid flow induced by a Rushton-turbine in baffled stirred-tank reactors. Chem Eng Sci. 1999; 54 (17) : 3921-41. (Pubitemid 29435222)
19. Bakker A, Van den Akker HEA. Single phase flow in stirred reactors. Chem Eng Res Des. 1998; 72: 583-593.
20. Jaworski Z, Zakrzewska B. Modelling of the turbulent wall jet generated by a pitched blade turbine impeller: the effect of turbulence model. Chem Eng Res Des. 2002; 80 (8) : 846-854. (Pubitemid 36440043)
21. Armenante PM, Luo C, Chou C-C, Fort I, Medek J. Velocity profiles in a closed, unbaffled vessel: comparison between experimental LDV data and numerical CFD predictions. Chem Eng Sci. 1997; 52 (20) : 3483-92. (Pubitemid 28010152)
22. Alcamo R, Micale G, Grisafi F, Brucato A, Ciofalo M. Large-eddy simulation of turbulent flow in an unbaffled stirred tank driven by a Rushton turbine. Chem Eng Sci. 2005; 60 (8-9) : 2303-16. (Pubitemid 40306785)
23. Murthy BN, Joshi JB. Assessment of standard k-e, RSM and LES turbulence models in a baffled stirred vessel agitated by various impeller designs. Chem Eng Sci. 2008; 63 (22) : 5468-95.
24. Torré J-P, Fletcher DF, Lasuye T, Xuereb C. Single and multiphase CFD approaches for modelling partially baffled stirred vessels: Comparison of experimental data with numerical predictions. Chem Eng Sci. 2007; 62 (22) : 6246-62. (Pubitemid 47516579)
25. Revstedt J, Fuchs L, Tragardh C. Large eddy simulation of the turbulent flow in a stirred tank. Chem Eng Sci. 1998; 53: 4041-53. (Pubitemid 29081576)
26. Eggels JGM. Direct and large-eddy simulation of turbulent fluid flow using the lattice-Boltzmann scheme. Int J Heat Fluid Flow. 1996; 17 (3) : 307-23. (Pubitemid 27021746)
27. Derksen J, Harry J, Van den Akker EA. Large eddy simulations on the flow driven by a Rushton turbine. AIChE J. 1999; 45 (2) : 209-21. (Pubitemid 29136606)
28. Derksen J. Large eddy simulations of agitated flow systems based on lattice-Boltzmann discretization. Lecture Notes in Computer Science. Amsterdam, Holland; 2002: 2329; 425-32.
29. Revstedt J, Fuchs L. Large eddy simulation of flow in stirred vessels. Chem Eng Tech. 2002; 25 (4) : 443-46. (Pubitemid 34452320)
30. Yeoh SL, Papadakis G, Yianneskis M. Numerical simulation of turbulent flow characteristics in a stirred vessel using the LES and RANS approaches with the sliding/deforming mesh methodology. Chem Eng Res Des. 2004; 82 (7) : 834-48. (Pubitemid 38978494)
31. Hartmann H, Derksen JJ, Montavon C, Pearson J, Hamill IS, van den Akker HEA. Assessment of large eddy and RANS stirred tank simulations by means of LDA. Chem Eng Sci. 2004; 59 (12) : 2419-32. (Pubitemid 38617144)
32. Derksen JJ, Kontomaris K, McLaughlin JB, Van den Akker HEA. Large-eddy simulation of single-phase flow dynamics and mixing in an industrial crystallizer. Chem Eng Res Des. 2007; 85 (2) : 169-79.
33. Delafosse A, Line A, Morchain J, Guiraud P. LES and URANS simulations of hydrodynamics in mixing tank: Comparison to PIV experiments. Chem Eng Res Des. 2008; 86 (12) : 1322-30.
34. Sommerfeld M, Decker S. State of the art and future trends in CFD simulation of stirred vessel hydrodynamics. Chem Eng Tech. 2004; 27 (3) : 215-24.
35. Xia JY, Wang YH, Zhang SL, Chen N, Yin P, Zhuang YP, et al. Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment. Biochem Eng J 2009; 43 (3) : 252-60.
36. Harris CK, Roekaerts D, Rosendal FJJ, Buitendijk FGJ, Daskopoulos P, Vreenegoor AJN, et al. Computational fluid dynamics for chemical reactor engineering. Chem Eng Sci. 1996; 51 (10) : 1569-94.
37. Aubin J, Fletcher DF, Xuereb C. Modeling turbulent flow in stirred tanks with CFD: the influence of the modeling approach, turbulence model and numerical scheme. Exper Therm Fluid Sci. 2004; 28 (5) : 431-45.
38. Deglon DA, Meyer CJ. Numerical considerations. Minerals Engineering. Num Cons Min Eng. 2006; 19 (10) : 1059-68.
39. Li M, White G, Wilkinson D. LDA measurements and CFD modeling of a stirred vessel with a retreat curve Impeller. Ind Eng Chem Res. 2004; 43: 6534-47.
40. Delafosse A, Morchain J, Guiraud P, Liné A. Trailing vortices generated by a Rushton turbine: Assessment of URANS and large Eddy simulations. Chem Eng Res Des. 2009; 87 (4) : 401-11.e