메뉴 건너뛰기




Volumn 35, Issue 3, 2010, Pages 676-680

Therapeutic implications of the pathophysiology of COPD

Author keywords

Emphysema; Gas trapping; Pulmonary C fibre afferents; Rapid shallow breathing

Indexed keywords

BREATHING; CHRONIC OBSTRUCTIVE LUNG DISEASE; DYSPNEA; EXERCISE; FORCED EXPIRATORY VOLUME; HUMAN; HYPERINFLATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESIDUAL VOLUME; REVIEW; VAGUS NERVE; VITAL CAPACITY;

EID: 77951179369     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00120609     Document Type: Review
Times cited : (91)

References (52)
  • 1
    • 0017402583 scopus 로고
    • The natural history of chronic airflow obstruction
    • *Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977; 1: 1645-1648.
    • (1977) Br Med J , vol.1 , pp. 1645-1648
    • Fletcher, C.1    Peto, R.2
  • 3
    • 0014039731 scopus 로고
    • Significance of the relationship between lung recoil and maximum expiratory flow
    • *Mead J, Turner JM, Macklem PT, et al. Significance of the relationship between lung recoil and maximum expiratory flow. J Appl Physiol 1967; 22: 95-108.
    • (1967) J Appl Physiol , vol.22 , pp. 95-108
    • Mead, J.1    Turner, J.M.2    Macklem, P.T.3
  • 4
    • 0014153081 scopus 로고
    • Determinants of maximal expiratory flow from the lungs
    • *Pride NB, Permutt S, Riley RL, et al. Determinants of maximal expiratory flow from the lungs. J Appl Physiol 1967; 23: 646-662.
    • (1967) J Appl Physiol , vol.23 , pp. 646-662
    • Pride, N.B.1    Permutt, S.2    Riley, R.L.3
  • 5
    • 0000890533 scopus 로고
    • The mechanical properties of the lungs in emphysema
    • *Mead J, Lindgren I, Gaensler EA. The mechanical properties of the lungs in emphysema. J Clin Invest 1955; 34: 1005-1016.
    • (1955) J Clin Invest , vol.34 , pp. 1005-1016
    • Mead, J.1    Lindgren, I.2    Gaensler, E.A.3
  • 6
    • 0014424329 scopus 로고
    • Site and nature of airway obstruction in chronic obstructive lung disease
    • *Hogg JC, Macklem PT, Thurlbeck WM. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968; 278: 1355-1365.
    • (1968) N Engl J Med , vol.278 , pp. 1355-1365
    • Hogg, J.C.1    Macklem, P.T.2    Thurlbeck, W.M.3
  • 7
    • 0014786734 scopus 로고
    • Stress distribution in lungs: A model of pulmonary elasticity
    • *Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 1970; 28: 596-608.
    • (1970) J Appl Physiol , vol.28 , pp. 596-608
    • Mead, J.1    Takishima, T.2    Leith, D.3
  • 8
    • 0025251194 scopus 로고
    • Reexamination of the elastic properties of emphysematous lungs
    • Macklem PT, Eidelman D. Reexamination of the elastic properties of emphysematous lungs. Respiration 1990; 57: 187-192.
    • (1990) Respiration , vol.57 , pp. 187-192
    • Macklem, P.T.1    Eidelman, D.2
  • 9
    • 0018646520 scopus 로고
    • A four-year follow-up study of lung mechanics in smokers
    • *Corbin RP, Loveland M, Martin RR, et al. A four-year follow-up study of lung mechanics in smokers. Am Rev Respir Dis 1979; 120: 293-304.
    • (1979) Am Rev Respir Dis , vol.120 , pp. 293-304
    • Corbin, R.P.1    Loveland, M.2    Martin, R.R.3
  • 10
    • 2142674710 scopus 로고
    • A report on the first two stages of the co-ordinated study of chronic bronchitis in the Department of Veterans Affairs, Canada
    • *Bates DV, Woolf CR, Paul GI. A report on the first two stages of the co-ordinated study of chronic bronchitis in the Department of Veterans Affairs, Canada. Med Serv J Can 1962; 18: 211-303.
    • (1962) Med Serv J Can , vol.18 , pp. 211-303
    • Bates, D.V.1    Woolf, C.R.2    Paul, G.I.3
  • 11
    • 0013869595 scopus 로고
    • Chronic bronchitis. Report on the third and fourth stages of the co-ordinated study of chronic bronchitis in the Department of Veterans Affairs, Canada
    • *Bates DV, Gordon CA, Paul GI, et al. Chronic bronchitis. Report on the third and fourth stages of the co-ordinated study of chronic bronchitis in the Department of Veterans Affairs, Canada. Med Serv J Can 1966; 22: 1-59.
    • (1966) Med Serv J Can , vol.22 , pp. 1-59
    • Bates, D.V.1    Gordon, C.A.2    Paul, G.I.3
  • 12
    • 55549096767 scopus 로고    scopus 로고
    • Airway bypass improves the mechanical properties of explanted emphysematous lungs
    • *Choong CK, Macklem PT, Pierce JA, et al. Airway bypass improves the mechanical properties of explanted emphysematous lungs. Am J Respir Crit Care Med 2008; 178: 902-905.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 902-905
    • Choong, C.K.1    Macklem, P.T.2    Pierce, J.A.3
  • 13
    • 0017816443 scopus 로고
    • The relations between structural changes in small airways and pulmonary-function tests
    • *Cosio M, Ghezzo H, Hogg JC, et al. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med. 1978; 298: 1277-1281.
    • (1978) N Engl J Med , vol.298 , pp. 1277-1281
    • Cosio, M.1    Ghezzo, H.2    Hogg, J.C.3
  • 14
    • 0014117656 scopus 로고
    • Mechanisms determining residual volume of the lungs in normal subjects
    • Leith DE, Mead J. Mechanisms determining residual volume of the lungs in normal subjects. J Appl Physiol 1967; 23: 221-227.
    • (1967) J Appl Physiol , vol.23 , pp. 221-227
    • Leith, D.E.1    Mead, J.2
  • 15
    • 34447315279 scopus 로고    scopus 로고
    • Transpleural ventilation of explanted human lungs
    • Choong CK, Macklem PT, Pierce JA, et al. Transpleural ventilation of explanted human lungs. Thorax 2007; 62: 623-630.
    • (2007) Thorax , vol.62 , pp. 623-630
    • Choong, C.K.1    Macklem, P.T.2    Pierce, J.A.3
  • 16
    • 61449229408 scopus 로고    scopus 로고
    • Therapeutic application of collateral ventilation with pulmonary drainage in the treatment of diffuse emphysema: Report of the first three cases
    • Saad R Jr, Neto VD, Botter M, et al. Therapeutic application of collateral ventilation with pulmonary drainage in the treatment of diffuse emphysema: report of the first three cases. J Bras Pneumol 2009; 35: 14-19.
    • (2009) J Bras Pneumol , vol.35 , pp. 14-19
    • Saad Jr., R.1    Neto, V.D.2    Botter, M.3
  • 18
    • 77951190229 scopus 로고    scopus 로고
    • Non-invasive measurement of breathing pattern in eucapnic and hypercapnic patients with COPD
    • Nerini M, Bianchi R, Romagnoli I, et al. Non-invasive measurement of breathing pattern in eucapnic and hypercapnic patients with COPD. Am J Resp Crit Care Med 2002; 165: A45.
    • (2002) Am J Resp Crit Care Med , vol.165
    • Nerini, M.1    Bianchi, R.2    Romagnoli, I.3
  • 20
    • 0019384232 scopus 로고
    • Pattern of breathing and carbon dioxide retention in chronic obstructive lung disease
    • Javaheri S, Blum J, Kazemi H. Pattern of breathing and carbon dioxide retention in chronic obstructive lung disease. Am J Med 1981; 71: 228-234.
    • (1981) Am J Med , vol.71 , pp. 228-234
    • Javaheri, S.1    Blum, J.2    Kazemi, H.3
  • 21
    • 0020381034 scopus 로고
    • Hypoxemia, hypercapnia, and breathing pattern in patients with chronic obstructive pulmonary disease
    • Parot S, Miara B, Milic-Emili J, et al. Hypoxemia, hypercapnia, and breathing pattern in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1982; 126: 882-886. (Pubitemid 13241076)
    • (1982) American Review of Respiratory Disease , vol.126 , Issue.5 , pp. 882-886
    • Parot, S.1    Miara, B.2    Milic-Emili, J.3    Gautier, H.4
  • 22
    • 0028871221 scopus 로고
    • Carbon dioxide responsiveness in COPD patients with and without chronic hypercapnia
    • Scano G, Spinelli A, Duranti R, et al. Carbon dioxide responsiveness in COPD patients with and without chronic hypercapnia. Eur Respir J 1995; 8: 78-85.
    • (1995) Eur Respir J , vol.8 , pp. 78-85
    • Scano, G.1    Spinelli, A.2    Duranti, R.3
  • 23
    • 0021673542 scopus 로고
    • Breathing patterns in patients with chronic obstructive pulmonary disease
    • Loveridge B, West P, Anthonisen NR, et al. Breathing patterns in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1984; 130: 730-733.
    • (1984) Am Rev Respir Dis , vol.130 , pp. 730-733
    • Loveridge, B.1    West, P.2    Anthonisen, N.R.3
  • 24
    • 0025905590 scopus 로고
    • Respiratory muscle weakness, pattern of breathing, and CO2 retention in chronic obstructive pulmonary disease
    • Rochester DF. Respiratory muscle weakness, pattern of breathing, and CO2 retention in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 145: 901-903.
    • (1991) Am Rev Respir Dis , vol.145 , pp. 901-903
    • Rochester, D.F.1
  • 25
    • 77049320081 scopus 로고
    • Mechanical factors in the distribution of pulmonary ventilation
    • *Otis A, McKerrow CB, Bartlett RA, et al. Mechanical factors in the distribution of pulmonary ventilation. J Appl Physiol 1956; 8: 427-443.
    • (1956) J Appl Physiol , vol.8 , pp. 427-443
    • Otis, A.1    McKerrow, C.B.2    Bartlett, R.A.3
  • 26
    • 0030879657 scopus 로고    scopus 로고
    • Human respiratory muscle actions and control during exercise
    • Aliverti A, Cala SJ, Duranti R, et al. Human respiratory muscle actions and control during exercise. J Appl Physiol 1997; 83: 1256-1269.
    • (1997) J Appl Physiol , vol.83 , pp. 1256-1269
    • Aliverti, A.1    Cala, S.J.2    Duranti, R.3
  • 27
    • 0015042496 scopus 로고
    • Ventilatory mechanics and expiratory flow limitation during exercise in patients with obstructive lung disease
    • *Potter WA, Olafsson S, Hyatt RE. Ventilatory mechanics and expiratory flow limitation during exercise in patients with obstructive lung disease. J Clin Invest 1971; 50: 910-919.
    • (1971) J Clin Invest , vol.50 , pp. 910-919
    • Potter, W.A.1    Olafsson, S.2    Hyatt, R.E.3
  • 28
    • 34250723825 scopus 로고    scopus 로고
    • A human model of the pathophysiology of COPD
    • Aliverti A, Kayser B, Macklem PT. A human model of the pathophysiology of COPD. Respirology 2007; 12: 478-485.
    • (2007) Respirology , vol.12 , pp. 478-485
    • Aliverti, A.1    Kayser, B.2    Macklem, P.T.3
  • 29
    • 1542509966 scopus 로고    scopus 로고
    • Regional chest wall volumes during exercise in chronic obstructive pulmonary disease
    • DOI 10.1136/thorax.2003.011494
    • Aliverti A, Stevenson N, Dellaca RL, et al. Regional chest wall volumes during exercise in chronic obstructive pulmonary disease. Thorax 2004; 59: 210-216. (Pubitemid 38339877)
    • (2004) Thorax , vol.59 , Issue.3 , pp. 210-216
    • Aliverti, A.1    Stevenson, N.2    Dellaca, R.L.3    Lo Mauro, A.4    Pedotti, A.5    Calverley, P.M.A.6
  • 30
    • 27744480192 scopus 로고    scopus 로고
    • Effect of salbutamol on lung function and chest wall volumes at rest and during exercise in COPD
    • Aliverti A, Rodger K, Dellaca RL, et al. Effect of salbutamol on lung function and chest wall volumes at rest and during exercise in COPD. Thorax 2005; 60: 916-924.
    • (2005) Thorax , vol.60 , pp. 916-924
    • Aliverti, A.1    Rodger, K.2    Dellaca, R.L.3
  • 32
    • 0036082035 scopus 로고    scopus 로고
    • Respiratory muscle dynamics and control during exercise with externally applied expiratory flow limitation
    • Aliverti A, Iandelli I, Duranti R, et al. Respiratory muscle dynamics and control during exercise with externally applied expiratory flow limitation. J Appl Physiol 2002; 92: 1953-1963.
    • (2002) J Appl Physiol , vol.92 , pp. 1953-1963
    • Aliverti, A.1    Iandelli, I.2    Duranti, R.3
  • 33
    • 27744460584 scopus 로고    scopus 로고
    • Influence of expiratory flowlimitation during exercise on systemic oxygen delivery in humans
    • Aliverti A, Dellaca RL, Lotti P, et al. Influence of expiratory flowlimitation during exercise on systemic oxygen delivery in humans. Eur J Appl Physiol 2005; 95: 229-242.
    • (2005) Eur J Appl Physiol , vol.95 , pp. 229-242
    • Aliverti, A.1    Dellaca, R.L.2    Lotti, P.3
  • 34
    • 0014308138 scopus 로고
    • Ventilatory cost of exercise in chronic obstructive pulmonary disease
    • *Levison H, Cherniack RM. Ventilatory cost of exercise in chronic obstructive pulmonary disease. J Appl Physiol 1968; 25: 21-27.
    • (1968) J Appl Physiol , vol.25 , pp. 21-27
    • Levison, H.1    Cherniack, R.M.2
  • 35
    • 0034950303 scopus 로고    scopus 로고
    • How and why exercise is impaired in COPD
    • Aliverti A, Macklem PT. How and why exercise is impaired in COPD. Respiration 2001; 68: 229-239.
    • (2001) Respiration , vol.68 , pp. 229-239
    • Aliverti, A.1    Macklem, P.T.2
  • 36
    • 57049112744 scopus 로고    scopus 로고
    • The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles
    • Aliverti A, Macklem PT. The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles. J Appl Physiol 2008; 105: 749-751.
    • (2008) J Appl Physiol , vol.105 , pp. 749-751
    • Aliverti, A.1    Macklem, P.T.2
  • 37
    • 0035446990 scopus 로고    scopus 로고
    • Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
    • O'Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: 770-777.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 770-777
    • O'Donnell, D.E.1    Revill, S.M.2    Webb, K.A.3
  • 38
    • 33749338192 scopus 로고    scopus 로고
    • Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD
    • O'Donnell DE, Hamilton AL, Webb KA. Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J Appl Physiol 2006; 101: 1025-1035.
    • (2006) J Appl Physiol , vol.101 , pp. 1025-1035
    • O'Donnell, D.E.1    Hamilton, A.L.2    Webb, K.A.3
  • 39
    • 0019133274 scopus 로고
    • Physiotherapy in hospitalized medical patients
    • Darrow G, Anthonisen NR. Physiotherapy in hospitalized medical patients. Am Rev Respir Dis 1980; 122: 155-158.
    • (1980) Am Rev Respir Dis , vol.122 , pp. 155-158
    • Darrow, G.1    Anthonisen, N.R.2
  • 40
    • 0022889668 scopus 로고
    • Pulmonary rehabilitation-physical modalities
    • Faling LJ. Pulmonary rehabilitation-physical modalities. Clin Chest Med 1986; 7: 599-618.
    • (1986) Clin Chest Med , vol.7 , pp. 599-618
    • Faling, L.J.1
  • 41
    • 0000634077 scopus 로고
    • The work of breathing
    • *Otis AB. The work of breathing. Physiol Rev 1954; 34: 449-458.
    • (1954) Physiol Rev , vol.34 , pp. 449-458
    • Otis, A.B.1
  • 42
    • 0013631149 scopus 로고
    • The effect of added elastic and non-elastic resistances on the pattern of breathing in normal subjects
    • Lond
    • *Christie RV, Eldridge FL, McIlroy MB, et al. The effect of added elastic and non-elastic resistances on the pattern of breathing in normal subjects. Clin Sci (Lond) 1956; 15: 337-344.
    • (1956) Clin Sci , vol.15 , pp. 337-344
    • Christie, R.V.1    Eldridge, F.L.2    McIlroy, M.B.3
  • 43
    • 29844442163 scopus 로고
    • Control of respiratory frequency
    • *Mead J. Control of respiratory frequency. Ann N Y Acad Sci 1963; 109: 724-729.
    • (1963) Ann N Y Acad Sci , vol.109 , pp. 724-729
    • Mead, J.1
  • 44
    • 0000054851 scopus 로고
    • The relationship of oxygen cost of breathing to respiratory mechanical work and respiratory force
    • *McGregor M, Becklake M. The relationship of oxygen cost of breathing to respiratory mechanical work and respiratory force. J Clin Invest 1961; 40: 971-980.
    • (1961) J Clin Invest , vol.40 , pp. 971-980
    • McGregor, M.1    Becklake, M.2
  • 45
    • 0035421665 scopus 로고    scopus 로고
    • Amplification of inflammation in emphysema and its association with latent adenoviral infection
    • Retamales I, Elliott WM, Meshi B, et al. Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med 2001; 164: 469-473.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 469-473
    • Retamales, I.1    Elliott, W.M.2    Meshi, B.3
  • 46
    • 0029186024 scopus 로고
    • Alveolar inflammation and its relation to emphysema in smokers
    • Finkelstein R, Fraser RS, Ghezzo H, et al. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med 1995; 152: 1666-1672.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 1666-1672
    • Finkelstein, R.1    Fraser, R.S.2    Ghezzo, H.3
  • 47
    • 77951200653 scopus 로고    scopus 로고
    • Reflexes evoked from the tracheobronchial tree and lungs
    • Cherniak NS, Widdicombe J, eds. Bethesda, American Physiological Society
    • Coleridge HM, Coleridge JCG. Reflexes evoked from the tracheobronchial tree and lungs. In: Cherniak NS, Widdicombe J, eds. Handbook of Physiology. Bethesda, American Physiological Society; pp 403-407.
    • Handbook of Physiology , pp. 403-407
    • Coleridge, H.M.1    Coleridge, J.C.G.2
  • 48
    • 0034829913 scopus 로고    scopus 로고
    • Modulation of airway sensitivity to inhaled irritants: Role of inflammatory mediators
    • Lee LY, Widdicombe JG. Modulation of airway sensitivity to inhaled irritants: role of inflammatory mediators. Environ Health Perspect 2001; 109: 585-589.
    • (2001) Environ Health Perspect , vol.109 , pp. 585-589
    • Lee, L.Y.1    Widdicombe, J.G.2
  • 49
    • 0035116372 scopus 로고    scopus 로고
    • Afferent properties and reflex functions of bronchopulmonary C-fibers
    • Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol 2001; 125: 47-65.
    • (2001) Respir Physiol , vol.125 , pp. 47-65
    • Lee, L.Y.1    Pisarri, T.E.2
  • 50
    • 0034522805 scopus 로고    scopus 로고
    • Peripheral muscle dysfunction in chronic obstructive pulmonary disease
    • Maltais F, LeBlanc P, Jobin J, et al. Peripheral muscle dysfunction in chronic obstructive pulmonary disease. Clin Chest Med. 2000; 21: 665-677.
    • (2000) Clin Chest Med , vol.21 , pp. 665-677
    • Maltais, F.1    LeBlanc, P.2    Jobin, J.3
  • 51
    • 0035985999 scopus 로고    scopus 로고
    • Alveolar hypercapnia augments pulmonary C-fiber responses to chemical stimulants: Role of hydrogen ion
    • Gu Q, Lee LY. Alveolar hypercapnia augments pulmonary C-fiber responses to chemical stimulants: role of hydrogen ion. J Appl Physiol 2002; 93: 181-188.
    • (2002) J Appl Physiol , vol.93 , pp. 181-188
    • Gu, Q.1    Lee, L.Y.2
  • 52
    • 0022003855 scopus 로고
    • Role of airway receptors in the breathing pattern of patients with chronic obstructive lung disease
    • Fennerty AG, Banks J, Bevan C, et al. Role of airway receptors in the breathing pattern of patients with chronic obstructive lung disease. Thorax 1985; 40: 268-271.
    • (1985) Thorax , vol.40 , pp. 268-271
    • Fennerty, A.G.1    Banks, J.2    Bevan, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.