The evaluation theory of free radical scavenging and the application to xanthine opxidase

Bulletin of the Chemical Society of Japan

Volumn 83, Issue 4, 2010, Pages 351-363

  Mitsuta, Keiichi ^a  

^a JEOL LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DISMUTATION; FREE RADICAL SCAVENGING; ORDER OF MAGNITUDE; REACTION THEORY; SECOND-ORDER RATE CONSTANTS; STOICHIOMETRIC COEFFICIENTS; SUPEROXIDE DISMUTASES; SUPEROXIDE RADICAL; TRAPPING AGENT; TRAPPING REACTION; XANTHINE OXIDASE;

COMPETITION; FREE RADICALS; OXYGEN; SPIN DYNAMICS;

RATE CONSTANTS;

EID: 77951158439     PISSN: 00092673     EISSN: 13480634     Source Type: Journal    
DOI: 10.1246/bcsj.20090311     Document Type: Article

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53. Milk xanthine oxidase is known to have an enzyme activity of more than 0.25 unit/mg protein and a molecular weight of ca. 300000. If 0.083 unit/mL XOD is converted into the molar concentration on the basis of these values, the result becomes ca. 1.1 × 106 M.
54. Based on eq 40 and the experimental conditions for 50% saturation (namely, kDMPO = 18M-1s-1, [DMPO] = 1.1 × 10-1 M, and [XOD] = 9.3 × 10-7 M) in our hypoxanthine-XOD system, the second-order rate constant kXOD for the reaction between XOD and O2-· is estimated to be roughly 2.1 × 106M-1 s-1 at pH 7.8. This value is 1.5 to 2.6 times that of 1.4 × 106 or 8.0 × 105M-1 s-1 estimated from our KO2system at pH 7.8. The cause of this difference seems to be the difference of the local pH of the reaction field in the early stage of the reaction between our two superoxide generating systems (Ref. 22).