M1-activated macrophages migration, a marker of aortic atheroma progression: A preclinical MRI study in mice

Investigative Radiology

Volumn 45, Issue 5, 2010, Pages 262-269

  Bessaad, Amine ^a   Sigovan, Monica ^a   Alsaid, Hasan ^a   De Souza, Geneviève ^a   Provost, Nicolas ^b   Majd, Zouher ^b   Menager, Christine ^c   Honnorat, Jèrôme ^d,e   Lagarde, Florence ^f   Nighoghossian, Norbert ^a,e   Nataf, Serge ^d,e   Canet Soulas, Emmanuelle ^a  

^a UNIVERSITÉ DE LYON   (France)

^b GENFIT   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITÉ LYON 1   (France)

^e HOSPICES CIVILS DE LYON   (France)

^f Institut des Sciences Analytiques   (France)

Author keywords

ApoE2 Ki; Atherosclerosis; Cell labeling; Chemokines; M1 activation; Macrophages; MRI

Indexed keywords

APOLIPOPROTEIN E2; FERRIC FERROCYANIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ARCH ANOMALY; ARTICLE; ATHEROMA; BONE MARROW CELL; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

EID: 77951134190     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/RLI.0b013e3181d78030     Document Type: Article

References (24)

1. Macleod MR, Amarenco P, Davis SM, et al. Atheroma of the aortic arch: an important and poorly recognized factor in the aetiology of stroke. Lancet Neurol. 2004;3:408-414.
2. Amarenco P, Rother J, Michel P, et al. Aortic arch atheroma and the risk of stroke. Curr Atheroscler Rep. 2006;8:343-346.
3. Sen S, Hinderliter A, Sen PK, et al. Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients. Stroke. 2007;38:2900-2905. (Pubitemid 350035682)
4. Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25: 677-686.
5. Martinez FO, Gordon S, Locati M, et al. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol. 2006;177:7303-7311.
6. Swirski FK, Pittet MJ, Kircher MF, et al. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci USA. 2006;103:10340-10345.
7. Qiu B, Gao F, Walczak P, et al. In vivo MR imaging of bone marrow cells trafficking to atherosclerotic plaques. J Magn Reson Imaging. 2007;26:339-343.
8. Briley-Saebo KC, Mulder WJ, Mani V, et al. Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes. J Magn Reson Imaging. 2007;26:460-479.
9. Trivedi RA, Gillard JH, Kirkpatrick PJ. Modern methods for imaging carotid atheroma. Br J Neurosurg. 2008;22:350-359.
10. Radermacher KA, Beghein N, Boutry S, et al. In vivo detection of inflammation using pegylated iron oxide particles targeted at E-selectin: a multi-modal approach using MR imaging and EPR spectroscopy. Invest Radiol. 2009;44:398-404.
11. Amirbekian V, Lipinski MJ, Briley-Saebo KC, et al. Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. Proc Natl Acad Sci USA. 2007;104:961-966.
12. Bulte JW, Kostura L, Mackay A, et al. Feridex-labeled mesenchymal stem cells: cellular differentiation and MR assessment in a canine myocardial infarction model. Acad Radiol. 2005;12(suppl 1):S2-S6.
13. Kircher MF, Grimm J, Swirski FK, et al. Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation. 2008;117:388-395.
14. Swirski FK, Libby P, Aikawa E, et al. Ly-6Chi monocytes dominate hyper-cholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117:195-205.
15. Whitman SC. A practical approach to using mice in atherosclerosis research. Clin Biochem Rev. 2004;25:81-93.
16. Sullivan PM, Mezdour H, Quarfordt SH, et al. Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest. 1998;102:130-135.
17. Alsaid H, Sabbah M, Bendahmane Z, et al. High-resolution contrast-enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice. Magn Reson Med. 2007;58:1157-1163.
18. Wilhelm C, Billotey C, Roger J, et al. Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. Biomaterials. 2003;24:1001-1011.
19. Sosnovik DE, Nahrendorf M, Weissleder R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation. 2007;115:2076-2086. (Pubitemid 46625959)
20. Wildgruber M, Lee H, Chudnovskiy A, et al. Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PloS One. 2009;4:e5663.
21. Kraitchman DL, Bulte JW. Imaging of stem cells using MRI. Basic Res Cardiol. 2008;103:105-113.
22. Hennuyer N, Tailleux A, Torpier G, et al. PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia. Arterioscler Thromb. 2005;25:1897-1902.
23. Chamorro A, Hallenbeck J. The harms and benefits of inflammatory and immune responses in vascular disease. Stroke. 2006;37:291-293.
24. Bouhlel MA, Staels B, Chinetti-Gbaguidi G. Peroxisome proliferator-acti-vated receptors\from active regulators of macrophage biology to pharmacological targets in the treatment of cardiovascular disease. J Intern Med. 2008;263:28-42.