The prevalence of Gly972Arg and C825T polymorphisms in Slovak women with polycystic ovary syndrome and their relation to the metabolic syndrome

Gynecological Endocrinology

Volumn 26, Issue 5, 2010, Pages 356-360

  Dravecká, Ingrid ^a   Lazúrová, Ivica ^a   Habalová, Viera ^a  

^a L PASTEUR UNIVERSITY HOSPITAL   (Slovakia)

Author keywords

GNB3 C825T; Insulin resistance; IRS 1 Gly972Arg; Polycystic ovary syndrome; Polymorphism

Indexed keywords

GLUCOSE; INSULIN; LIPOPROTEIN;

ADULT; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; IRS 1 GENE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SLOVAKIA; WAIST CIRCUMFERENCE;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; FEMALE; GENOTYPE; GLYCINE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LIPIDS; LIPOPROTEINS; METABOLIC SYNDROME X; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, GENETIC; SLOVAKIA;

EID: 77951129216     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590903511497     Document Type: Article

References (14)

1. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-47.
2. Ertunc D, Tok EC, Aktas A, Erdal EM, Dilek S. The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome. Hum Reprod 2005;20:1207-1212.
3. Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI. Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol metab 2002;87:4297-4300.
4. Carvalho E, Jansson PA, Axelsen M, Eriksson JW, Huang X, Groop L, Rondinone C, Sjostrom L, Smith U. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB J 1999;13:2173-2178.
5. Baroni MG, D'Andrea MP, Montali A, Pannitteri G, Barilla F, Campagna F, Mazzei E, Lovari S, Seccareccia F, Campa PP, et al. A common mutation of the insulin receptor substrate-1 gene is a risk factor of coronary artery disease. Arterioscler Thromb Vasc Biol 1999;19:2975-2980.
6. Siffert W. G protein polymorphism in hypertension, atherosclerosis, and diabetes. Annu Rev Med 2005;56:17-28.
7. Sir-Petermann T, Perez-Bravo F, Angel B, Maliqueo M, Calvillan M, Palomino A. G972R polymorphism of IRS-1 in women with polycystic ovary syndrome. Diabetologia 2001;44:1200-1201.
8. El Mkadem SA, Lautier C, Macari F, Molinari N, Lefebvre P, Renard E, Gris JC, Cros G, Daures JP, Bringer J, et al. Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome. Diabetes 2001;50:2164-2168.
9. Haap M, Machicao F, Stefan N, Thamer C, Tschritter O, Schunck F, Wallwiener D, Stumvoll M, Häring HU, Fritsche A. Genetic determinants of insulin action in polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2005;113:275-281.
10. Hahn S, Frey UH, Siffert W, Tan S, Mann K, Janssen OE. The CC genotype of the GNAS T393C polymorpism is associated with obesity and insulin resistance in women with polycystic ovary syndrome. Eur J Endocrinol 2006;155:763-770. (Pubitemid 44857502)
11. Morrison AC, Doris PA, Folsom AR, Nieto FJ, Boerwinkle E. G-protein b3 subunit and a-adducin polymorphisms and risk of subclinical and clinical stroke for the Atherosclerosis Risk in Communities Study. Stroke 2001;32:822-829.
12. Dilek S, Ertunc D, Tok EC, Erdal EM, Aktas A. Association of Gly972Arg variant of insulin receptor substrate-1 with metabolic features in women with polycystic ovary syndrome. Fertil Steril 2005;84:407-412.
13. Sir-Petermann T, Angel B, Maliqueo M, Santos JL, Riesco MV, Toloza H, Pérez-Bravo F. Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a highglycemic or low-glycemic carbohydrate load. Nutrition 2004;20:905-910.
14. Villuendas G, Botella Carretero JI, Roldán B, Sancho J, Escobar-Morreale F, San Millán JL. Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene int the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls. Hum Reprod 2005;20:3184-3191.