Evaluation of implementation of a fully automated algorithm (enhanced model predictive control) in an interacting infusion pump system for establishment of tight glycemic control in medical intensive care unit patients

Journal of Diabetes Science and Technology

Volumn 2, Issue 6, 2008, Pages 963-970

  Kulnik, Roman ^a   Plank, Johannes ^a   Pachler, Christoph ^a   Wilinska, Malgorzata E ^b   Groselj Strele, Andrea ^a   Röthlein, Doris ^c   Wufka, Matthias ^c   Kachel, Norman ^c   Smolle, Karl Heinz ^a   Perl, Sabine ^a   Pieber, Thomas Rudolf ^a   Hovorka, Roman ^b   Ellmerer, Martin ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c B Braun Melsungen AG   (Germany)

Author keywords

Algorithms; Critical care nursing; Hyperglycemia management; Insulin infusion systems

Indexed keywords

EID: 77951098777     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229680800200606     Document Type: Conference Paper

References (29)

1. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000;355(9206):773-8.
2. Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma. 2003;55(1):33-8.
3. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87(3):978-82.
4. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001;32(10):2426-32.
5. Levetan CS, Passaro M, Jablonski K, Kass M, Ratner RE. Unrecognized diabetes among hospitalized patients. Diabetes Care. 1998;21(2):246-9.
6. Van Den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345(19):1359-67.
7. Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc. 2004;79(8):992-1000.
8. Van Den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449-61.
9. Van Den Berghe G, Wilmer A, Milants I, Wouters PJ, Bouckaert B, Bruyninckx F, Bouillon R, Schetz M. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes. 2006;55(11):3151-9.
10. Devos P, Preiser J, Melot C. Impact of tight glucose control by intensive insulin therapy on ICU mortality and the rate of hypoglycemia: final results of the GLUCONTROL study [abstract]. Intensive Care Med. 2007;33(2):189.
11. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K; German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125-39.
12. Perreaux J, Devos P, Preiser J, Melot C. Impact of the implementation of tight glucose control by intensive insulin therapy on the nursing workload: data from the GLUCONTROL study [abstract]. Intensive Care Med. 2007;33(2):54.
13. Goldberg PA, Siegel MD, Sherwin RS, Halickman JI, Lee M, Bailey VA, Lee SL, Dziura JD, Inzucchi SE. Implementation of a safe and effective insulin infusion protocol in a medical intensive care unit. Diabetes Care. 2004;27(2):461-7.
14. Plank J, Blaha J, Cordingley J, Wilinska ME, Chassin LJ, Morgan C, Squire S, Haluzik M, Kremen J, Svacina S, Toller W, Plasnik A, Ellmerer M, Hovorka R, Pieber TR. Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients. Diabetes Care. 2006;29(2):271-6.
15. Hovorka R, Kremen J, Blaha J, Matias M, Anderlova K, Bosanska L, Roubicek T, Wilinska ME, Chassin LJ, Svacina S, Haluzik M. Blood glucose control by a model predictive control algorithm with variable sampling rate versus a routine glucose management protocol in cardiac surgery patients: a randomized controlled trial. J Clin Endocrinol Metab. 2007;92(8):2960-4.
16. Pachler C, Plank J, Weinhandl H, Chassin LJ, Wilinska ME, Kulnik R, Kaufmann P, Smolle KH, Pilger E, Pieber TR, Ellmerer M, Hovorka R. Tight glycaemic control by an automated algorithm wit h time-variant sampling in medical ICU patients. Intensive Care Med. 2008;34(7):1224-30.
17. Wentholt IM, Hoekstra JB, Devries JH. Continuous glucose monitors: the long-awaited watch dogs? Diabetes Technol Ther. 2007;9(5):399-409.
18. Vriesendorp TM, Van Santen S, De Vries JH, De Jonge E, Rosendaal FR, Schultz MJ, Hoekstra JB. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med. 2006;34(1):96-101.
19. Vogelzang M, Van Der Horst IC, Nijsten MW. Hyperglycaemic index as a tool to assess glucose control: a retrospective study. Crit Care. 2004;8(3):R122-7.
20. Cryer PE. Hypoglycaemia: the limiting factor in the glycaemic management of the critically ill? Diabetologia. 2006;49(8):1722-5.
21. Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med. 2007;35(10):2262-7.
22. Furnary AP, Gao G, Grunkemeier GL, Wu Y, Zerr KJ, Bookin SO, Floten HS, Starr A. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003;125(5):1007-21.
23. Clayton SB, Mazur JE, Condren S, Hermayer KL, Strange C. Evaluation of an intensive insulin protocol for septic patients in a medical intensive care unit. Crit Care Med. 2006;34(12):2974-8.
24. Meynaar IA, Dawson L, Tangkau PL, Salm EF, Rijks L. Introduction and evaluation of a computerised insulin protocol. Intensive Care Med. 2007;33(4):591-6.
25. Meijering S, Corstjens AM, Tulleken JE, Meertens JH, Zijlstra JG, Ligtenberg JJ. Towards a feasible algorithm for tight glycaemic control in critically ill patients: a systematic review of the literature. Crit Care. 2006;10(1):R19.
26. Malesker MA, Foral PA, McPhillips AC, Christensen KJ, Chang JA, Hilleman DE. An efficiency evaluation of protocols for tight glycemic control in intensive care units. Am J Crit Care. 2007;16(6):589-98.
27. Shulman R, Finney SJ, O'Sullivan C, Glynne PA, Greene R. Tight glycaemic control: a prospective observational study of a computerised decision-supported intensive insulin therapy protocol. Crit Care. 2007;11(4):R75.
28. Oeyen SG, Hoste EA, Roosens CD, Decruyenaere JM, Blot SI. Adherence to and efficacy and safety of an insulin protocol in the critically ill: a prospective observational study. Am J Crit Care. 2007;16(6):599-608.
29. Vlasselaers D, Notele G, Van Den Berghe G, Wouters P, Chassin L, Wilinska G, Hovorka R. Tight glycaemic control in ICU with model predictive control and time-variant sampling [abstract]. Intensive Care Med. 2006;32(1):272.