Effects of ammonium chloride ingestion on phosphocreatine metabolism during moderate- and heavy-intensity plantar-flexion exercise

European Journal of Applied Physiology

Volumn 108, Issue 6, 2010, Pages 1189-1200

  Churchward Venne, Tyler A ^a   Kowalchuk, John M ^a   Marsh, Greg D ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

31 Phosphorus magnetic resonance spectroscopy; Intracellular acid base status; Metabolic acidosis; Phosphocreatine kinetics

Indexed keywords

AMMONIUM CHLORIDE; CREATINE PHOSPHATE;

ADULT; ANKLE; ARTICLE; DRUG EFFECT; ENDURANCE; EXERCISE; HUMAN; MALE; METABOLIC CLEARANCE RATE; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY;

ADMINISTRATION, ORAL; AMMONIUM CHLORIDE; ANKLE JOINT; HUMANS; MALE; METABOLIC CLEARANCE RATE; PHOSPHOCREATINE; PHYSICAL ENDURANCE; PHYSICAL EXERTION; YOUNG ADULT;

EID: 77951092982     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-009-1327-8     Document Type: Article

References (60)

1. DG Allen GD Lamb H Westerblad 2008 Skeletal muscle fatigue: cellular mechanisms Physiol Rev 88 287 332 10.1152/physrev.00015.2007 1:CAS:528:DC%2BD1cXitVKgtrg%3D 18195089
2. TJ Barstow S Buchthal S Zanconato DM Cooper 1994 Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise J Appl Physiol 77 1742 1749 1:STN:280:DyaK2M7jsl2iuw%3D%3D 7836194
3. TJ Barstow AM Jones PH Nguyen R Casaburi 1996 Influence of muscle fibre and pedal frequency on oxygen uptake kinetics of heavy exercise J Appl Physiol 81 1642 1650 1:STN:280:DyaK2s%2FmtVGgtg%3D%3D 8904581
4. 1H MR spectra: prior knowledge, peak elimination, and filtering NMR Biomed 12 205 216 10.1002/(SICI)1099-1492(199906) 12:4<205::AID-NBM558>3.0.CO;2-1 1:CAS:528:DyaK1MXltVWrs78%3D 10421912 (Pubitemid 29325667)
5. 2 slow component J Physiol Anthropol 26 541 546 10.2114/jpa2.26.541 18092510
6. B Chance H Conrad 1959 Acid-linked functions of intermediates in oxidative phosphorylation. II. Experimental studies of the effect of pH upon respiratory, phosphorylative and transfer activities of liver and heart mitochondria J Biol Chem 234 1568 1570 1:CAS:528:DyaG1MXpsFSlsA%3D%3D 13654418
7. B Chance GR Williams 1955 Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization J Biol Chem 217 383 393 1:CAS:528:DyaG28XitVGhsA%3D%3D 13271402
8. B Chance CM Williams 1956 The respiratory chain and oxidative phosphorylation Adv Enzymol Relat Subj Biochem 17 65 134 10.1002/9780470122624. ch2 1:CAS:528:DyaG2sXktlKgsw%3D%3D 13313307
9. B Chance JS Leigh BJ Clark J Maris J Kent S Nioka D Smith 1985 Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function Proc Natl Acad Sci USA 82 8384 8388 10.1073/pnas.82.24.8384 1:CAS:528:DyaL28Xms1Cksw%3D%3D 3866229
10. KE Conley WF Kemper GJ Crowther 2001 Limits to sustainable muscle performance: interaction between glycolysis and oxidative phosphorylation J Exp Biol 204 3189 3194 1:CAS:528:DC%2BD3MXnvVGhuro%3D 11581333
11. MT Crow MJ Kushmerick 1982 Chemical energetics of slow- and fast-twitch muscles of the mouse J Gen Physiol 79 147 166 10.1085/jgp.79.1.147 1:CAS:528:DyaL38Xms1CntQ%3D%3D 7061985
12. RH Fitts 1994 Cellular mechanisms of muscle fatigue Physiol Rev 74 49 94 1:CAS:528:DyaK2cXhvVOktrs%3D 8295935
13. --induced alkalosis reduces the phosphocreatine slow component during heavy-intensity forearm exercise J Appl Physiol 99 1668 1675 10.1152/japplphysiol.01200.2004 1:CAS:528:DC%2BD2MXht1CrtbnJ 16002768 (Pubitemid 41547161)
14. SC Forbes JM Kowalchuk RT Thompson GD Marsh 2007 Effects of hyperventilation on phosphocreatine kinetics and muscle deoxygenation during moderate-intensity plantar flexion exercise J Appl Physiol 102 1565 1573 10.1152/japplphysiol.00895.2006 1:CAS:528:DC%2BD2sXlt1ant7s%3D 17218429 (Pubitemid 46571053)
15. SC Forbes GH Raymer JM Kowalchuk RT Thompson GD Marsh 2008 Effects of recovery time on phosphocreatine kinetics during repeated bouts of heavy intensity exercise Eur J Appl Physiol 103 665 675 10.1007/s00421-008-0762-2 1:CAS:528:DC%2BD1cXpt1Cqs7w%3D 18481078
16. SW Garland W Wang SA Ward 2006 Indices of electromyographic activity and the "slow" component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans Eur J Appl Physiol 97 413 423 10.1007/s00421-006-0185-x 16685552 (Pubitemid 43951028)
17. EM Golding WE Teague GP Dobson 1995 Adjustment of K to varying pH and pMg for the creatine kinase, adenylate kinase and ATP hydrolysis equilibria permitting quantitative bioenergetic assessment J Exp Biol 198 1775 1782 1:CAS:528:DyaK2MXnvFShtLY%3D 7636446
18. 2 uptake kinetics in humans: implications for metabolic control J Appl Physiol 80 988 998 1:STN:280:DyaK283kvFGksg%3D%3D 8964765
19. SJ Harkema RA Meyer 1997 Effect of acidosis on control of respiration in skeletal muscle Am J Physiol 272 C491 C500 1:CAS:528:DyaK2sXhvVCrsLg%3D 9124292
20. SJ Harkema GR Adams RA Meyer 1997 Acidosis has no effect on the ATP cost of contraction in cat fast- and slow-twitch skeletal muscles Am J Physiol 272 C485 C490 1:CAS:528:DyaK2sXhvVCrsL0%3D 9124291
21. RC Harris E Hultman LO Nordesjo 1974 Glycogen, glycolytic intermediates and high energy phosphates determined in biopsy samples of musculus quadriceps of man at rest: methods and variance of values Scand J Clin Lab Invest 33 109 120 1:CAS:528:DyaE2cXkslCgtrw%3D 4852173
22. LJ Hasler CA Kindig RS Richardson MC Hogan 2004 The role of oxygen in determining phosphocreatine onset kinetics in exercising humans J Physiol 558 985 992 10.1113/jphysiol.2004.062042 (Pubitemid 39199118)
23. MG Hollidge-Horvat ML Parolin D Wong NL Jones GJF Heigenhauser 1999 Effect of induced metabolic acidosis on human skeletal muscle metabolism during exercise Am J Physiol 277 E647 E658 1:CAS:528:DyaK1MXntFCjt70%3D 10516124
24. VL Hood C Schubert U Keller S Muller 1988 Effect of systemic pH and pHi and lactic acid generation in exhaustive forearm exercise Am J Physiol 255 F479 F485 1:STN:280:DyaL1czisVKgtg%3D%3D 3414804
25. RL Hughson M Morrissey 1982 Delayed kinetics of respiratory gas exchange in the transition from prior exercise J Appl Physiol 52 921 929 1:STN:280:DyaL383htlCltw%3D%3D 6806226
26. 2 kinetics: a review Int J Sports Med 4 31 39 10.1055/s-2008-1026013 1:STN:280:DyaL3s7osV2iug%3D%3D 6341268
27. E Hultman S Del Canale H Sjoholm 1985 Effect of induced metabolic acidosis on intracellular pH, buffer capacity and contraction force of human skeletal muscle Clin Sci 69 505 510 1:CAS:528:DyaL2MXmtFaktbw%3D 4053505
28. NL Jones JR Sutton R Taylor CJ Toews 1977 Effect of pH on cardiorespiratory and metabolic responses to exercise J Appl Physiol 43 959 964 1:CAS:528:DyaE1cXhvFyqtw%3D%3D 24031
29. AM Jones DP Wilkerson J Fulford 2008 Muscle [phosphocreatine] dynamics following the onset of exercise in humans: the influence of baseline work-rate J Physiol 586 889 898 10.1113/jphysiol.2007.142026 1:CAS:528:DC%2BD1cXit1ymsr4%3D 18063663 (Pubitemid 351194125)
30. SA Jubrais GJ Crowther EG Shankland RK Gronka KE Conley 2003 Acidosis inhibits oxidative phosphorylation in contracting human skeletal muscle in vivo J Physiol 553 589 599 10.1113/jphysiol.2003.045872 (Pubitemid 37527556)
31. JM Kowalchuk GJF Heigenhauser NL Jones 1984 Effect of pH on metabolic and cardiorespiratory responses during progressive exercise J Appl Physiol 57 1558 1563 1:STN:280:DyaL2M7gsVCksA%3D%3D 6520052
32. MJ Kushmerick RA Meyer TR Brown 1992 Regulation of oxygen consumption in fast- and slow-twitch muscle Am J Physiol 263 C598 C606 1:CAS:528: DyaK38XmtV2ktrY%3D 1415510
33. 2 uptake, leg blood flow, and muscle deoxygenation are slowed in the upper compared with lower region of the moderate-intensity exercise domain J Appl Physiol 99 1822 1834 10.1152/japplphysiol.01183.2004 16037398 (Pubitemid 41547180)
34. 2 and phosphorylcreatine level. Implications for the control of respiration J Gen Physiol 86 135 165 10.1085/jgp.86.1.135 1:CAS:528:DyaL2MXltVahu70%3D 4031824 (Pubitemid 15073068)
35. DW Marquardt 1963 An algorithm for least-squares estimation of non-linear parameters J Soc Ind Appl Math 11 431 441 10.1137/0111030
36. GD Marsh DH Paterson JJ Potwarka RT Thompson AA Driedger 1991 Coincident thresholds in intracellular phosphorylation potential and pH during progressive exercise J Appl Physiol 71 1076 1081 1:CAS:528:DyaK3MXmsFarsLw%3D 1757303
37. GD Marsh DH Paterson JJ Potwarka RT Thompson 1993 Transient changes in muscle high-energy phosphates during moderate exercise J Appl Physiol 75 648 656 1:CAS:528:DyaK2cXhtVeht7o%3D 8226464
38. CR McCreary PD Chilibeck GD Marsh DH Paterson DA Cunningham RT Thompson 1996 Kinetics of pulmonary oxygen uptake and muscle phosphates during moderate-intensity calf exercise J Appl Physiol 81 1331 1338 1:STN:280:DyaK2s%2FksVOjsg%3D%3D 8889771
39. RA Meyer 1988 A linear model of muscle respiration explains monoexponential phosphocreatine changes Am J Physiol 254 C548 C553 1:CAS:528:DyaL1cXmt1Ont7k%3D 3354652
40. RA Meyer 1989 Linear dependence of muscle phosphocreatine kinetics on total creatine content Am J Physiol 257 C1149 C1157 1:CAS:528: DyaK3cXnsVCitw%3D%3D 2610252
41. DC Poole W Schaffartzik DR Knight T Derion B Kennedy HJ Guy R Prediletto PD Wagner 1991 Contribution of the exercising legs to the slow component of oxygen uptake kinetics in humans J Appl Physiol 71 1245 1260 1:STN:280:DyaK38%2FpvVCgsQ%3D%3D 1757346
42. 2 slow component: physiological and functional significance Med Sci Sports Exerc 26 1354 1358 1:STN:280:DyaK2M7jvFOqsw%3D%3D 7837956
43. GH Raymer BL Allman CL Rice GD Marsh RT Thompson 2006 Characteristics of an MR-compatible ankle exercise ergometer for a 3.0 T head-only MR scanner Med Eng Phys 28 489 494 10.1016/j.medengphy.2005.07.021 16162418
44. 2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans J Physiol 518 921 932 10.1111/j.1469-7793.1999.0921p.x 1:CAS:528:DyaK1MXlsFGjsro%3D 10421675 (Pubitemid 29387258)
45. 2 uptake during exercise J Appl Physiol 93 2059 2069 1:STN:280:DC%2BD38jhvFaisw%3D%3D 12391122
46. 2 uptake between the on- and off-transients of moderate- and high-intensity exercise in humans J Physiol 541 991 1002 10.1113/jphysiol.2001.012910 1:CAS:528: DC%2BD38XlsVWnsL0%3D 12068057 (Pubitemid 35190257)
47. 31P metabolite kinetics during high-intensity exercise in humans J Appl Physiol 95 1105 1115 1:CAS:528:DC%2BD3sXnsFCjtr4%3D 12754181
48. K Sahlin L Edstrom H Sjoholm 1983 Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle Am J Physiol 245 C15 C20 1:CAS:528:DyaL3sXks1ymsb4%3D 6408927
49. A Santalla M Perez M Montilla L Vicente R Davison C Earnest A Lucia 2003 Sodium bicarbonate ingestion does not alter the slow component of oxygen uptake kinetics in professional cyclists J Sports Sci 21 39 47 10.1080/ 0264041031000070949 12587890 (Pubitemid 36175597)
50. 2 uptake is not accompanied by changes in muscle EMG during repeated bouts of heavy exercise in humans J Physiol 15 245 256 10.1111/j.1469-7793.2001.0245j.x (Pubitemid 32178041)
51. 31P nuclear magnetic resonance study Mol Biol Med 1 77 94 1:CAS:528:DyaL3sXlslahtbk%3D 6679873
52. N Tordi S Perrey A Harvey RL Hughson 2003 Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans J Appl Physiol 94 533 541 1:STN:280:DC%2BD3s%2FisV2ltg%3D%3D 12391053
53. E Veith 1989 Fitting piecewise linear regression functions to biological responses J Appl Physiol 67 390 396
54. B Walsh T Tiivel M Tonkonogi K Sahlin 2002 Increased concentrations of Pi and lactic acid reduce creatine-stimulated respiration in muscle fibres J Appl Physiol 92 2273 2276 1:CAS:528:DC%2BD38Xks1aju78%3D 12015336
55. BJ Whipp K Wasserman 1972 Oxygen uptake kinetics for various intensities of constant-load work J Appl Physiol 33 351 356 1:STN:280:DyaE383mslKksQ%3D%3D 5056210
56. BJ Whipp HB Rossiter SA Ward 2002 Exertional oxygen uptake kinetics: a stamen of stamina? Biochem Soc Trans 30 237 247 10.1042/BST0300237 1:CAS:528:DC%2BD38XjvVKgsrY%3D 12023858
57. F Wu F Yang KC Vinnakota DA Beard 2007 Computer modeling of mitochondrial tricarboxylic acid cycle, oxidative phosphorylation, metabolite transport, and electrophysiology J Biol Chem 282 24525 24537 10.1074/jbc.M701024200 1:CAS:528:DC%2BD2sXpt1Slsrc%3D 17591785 (Pubitemid 47347524)
58. 2 kinetics in humans J Physiol Pharmacol 48 211 223 1:CAS:528:DyaK2sXkslymu7k%3D 9223026
59. 2 kinetics in humans J Physiol Pharmacol 49 443 455 1:CAS:528:DyaK1cXmvFant7Y%3D 9789796
60. 2 kinetics J Appl Physiol 105 575 580 10.1152/japplphysiol.01129.2007 18483168