Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels

Biomaterials

Volumn 31, Issue 17, 2010, Pages 4657-4671

  Mehta, Geeta ^a   Williams, Courtney M ^a   Alvarez, Luis ^a   Lesniewski, Martha ^b   Kamm, Roger D ^a   Griffith, Linda G ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b Georgia Institute of Technology   (United States)

Author keywords

Extracellular matrix; Heparin binding domain; RGD cell binding domain; Self assembled peptide gel; Tethered growth factor

Indexed keywords

CELL-BINDING DOMAIN; EXTRACELLULAR MATRICES; GROWTH FACTOR; HEPARIN BINDING DOMAINS; SELF ASSEMBLED PEPTIDE GEL; SELF-ASSEMBLED PEPTIDES;

ADHESION; AVIATION; BIOACTIVITY; CELL CULTURE; CHELATION; DNA; GENES; HYSTERESIS MOTORS; LIGANDS; METABOLISM; PEPTIDES; PHOSPHORYLATION; POLYSACCHARIDES; TISSUE;

GELS;

ARGINYLGLYCYLASPARTIC ACID; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBRONECTIN; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NANOFIBER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL CULTURE; CELL FUNCTION; CELL SPREADING; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; HYDROGEL; LIVER CELL; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; CELLS, CULTURED; DNA; EPIDERMAL GROWTH FACTOR; FIBRONECTINS; HEPATOCYTES; HUMANS; HYDROGELS; IMMUNOPRECIPITATION; MALE; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

RATTUS;

EID: 77951092829     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.138     Document Type: Article

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