Dose-dependent adsorptive capacity of activated charcoal for gastrointestinal decontamination of a simulated paracetamol overdose in human volunteers

Basic and Clinical Pharmacology and Toxicology

Volumn 106, Issue 5, 2010, Pages 406-410

  Gude, Anne Bolette Jill ^a   Hoegberg, Lotte Christine Groth ^a   Angelo, Helle Riis ^a   Christensen, Hanne Rolighed ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; CHARCOAL; PARACETAMOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DOSE RESPONSE; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG OVERDOSE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ACETAMINOPHEN; ADSORPTION; ADULT; ANTIDOTES; CHARCOAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL TRACT; HUMANS; MALE; OVERDOSE;

EID: 77951087638     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00503.x     Document Type: Article

References (18)

1. Pond SM. Role of repeated oral doses of activated charcoal in clinical toxicology. Med Toxicol 1986 1 : 3 11.
2. Berlinger WG, Spector R, Goldberg MJ, Johnson GF, Quee CK, Berg MJ. Enhancement of theophylline clearance by oral activated charcoal. Clin Pharmacol Ther 1983 33 : 351 354.
3. Cooney DO. Some basic aspects of antidotal charcoal. In : Activated Charcoal in Medical Applications. Marcel Dekker Inc
4. Christophersen AB, Hoegberg LCG. Techniques used to prevent gastrointestinal absorption. In : Flomenbaum NE, Goldfrank LR, Hoffman RS, Howland MA, Lewin NA, Nelson LS (eds). Goldfrank's Toxicologic Emergencies, 8th edn. McGraw-Hill
5. Hoegberg LCG, Angelo HR, Christophersen AB, Christensen HR. Effect of ethanol and pH on the adsorption of acetaminophen (paracetamol) to high surface activated charcoal, in vitro studies. J Toxicol Clin Toxicol 2002 40 : 59 67.
6. Christophersen AB, Levin D, Hoegberg LCG, Angelo HR, Kampmann JP. Activated charcoal alone or after gastric lavage: a simulated large paracetamol intoxication. Br J Clin Pharmacol 2002 53 : 312 317.
7. Olkkola KT. Effect of charcoal-drug ratio on antidotal efficacy of oral activated charcoal in man. Br J Clin Pharmacol 1985 19 : 767 773.
8. Roberts JR, Gracely EJ, Schoffstall JM. Advantage of high-surface-area charcoal for gastrointestinal decontamination in a human acetaminophen ingestion model. Acad Emerg Med 1997 4 : 167 174.
9. Altman DG. Comparing groups - continuous data. In : Practical Statistics for Medical Research. Chapman & Hall
10. Bryant TN. Computer software for calculating confidence intervals. In : Altman DG, Machin D, Bryant TN, Gardner MJ (eds). Statistics with Confidence, 2nd edn. BMJ Books
11. Levy G. Gastrointestinal clearance of drugs with activated charcoal. N Engl J Med 1982 307 : 676 678.
12. Derlet RW, Albertson TE. Activated charcoal - past, present and future. West J Med 1986 145 : 493 496.
13. Neuvonen PJ, Elonen E. Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man. Eur J Clin Pharmacol 1980 17 : 51 7.
14. Berg MJ, Berlinger WG, Goldberg MJ, Spector R, Johnson GF. Acceleration of the body clearance of phenobarbital by oral activated charcoal. N Engl J Med 1982 307 : 642 644.
15. Benet LZ, Øie S, Schwartz JB. Design and optimization of dosage regimens; pharmacokinetic data. In : Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG (eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th edn. McGraw-Hill
16. Sato RL, Wong JJ, Sumida SM, Marn RY, Enoki NR, Yamamoto LG. Efficacy of superactivated charcoal administered late (3 hours) after acetaminophen overdose. Am J Emerg Med 2003 21 : 189 191.
17. Spiller HA, Winter ML, Klein-Schwartz W, Bangh SA. Efficacy of activated charcoal administered more than four hours after acetaminophen overdose. J Emerg Med 2006 30 : 1 5.
18. Moore JG, Christian PE, Brown JA, Brophy C, Datz F, Taylor A et al. Influence of meal weight and caloric content on gastric emptying of meals in man. Dig Dis Sci 1984 29 : 513 519.