Free light chain: A novel predictor of adverse outcome in chronic lymphocytic leukemia

European Journal of Haematology

Volumn 84, Issue 5, 2010, Pages 406-411

  Yegin, Zeynep A ^a   Özkurt, Zübeyde N ^a   Yàci, Münci ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Chronic lymphocytic leukemia; Free light chain; Free light chain ratio; Prognosis

Indexed keywords

CD38 ANTIGEN; IMMUNOGLOBULIN LIGHT CHAIN; LACTATE DEHYDROGENASE; PROTEIN KINASE ZAP 70;

ADULT; ADVERSE OUTCOME; AGE; AGED; ARTICLE; CANCER STAGING; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENETIC RISK; HEMOGLOBIN BLOOD LEVEL; HUMAN; LYMPHOCYTE COUNT; LYMPHOCYTE STRUCTURE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL TIME; THROMBOCYTE COUNT;

ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; SURVIVAL RATE;

EID: 77951080815     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2010.01412.x     Document Type: Article

References (25)

1. Oscier D, Fegan C, Hillmen P, Illidge T, Johnson S, Maguire P, Matutes E, Milligan D. Guidelines on the diagnosis and management of chronic lymphocytic leukaemia. Br J Haematol 2004 125 : 294 317. (Pubitemid 38621761)
2. Durak B, Akay OM, Aslan V, Ozdemir M, Sahin F, Artan S, Gülbas Z. Prognostic impact of chromosome alterations detected by FISH in Turkish patients with B-cell chronic lymphocytic leukemia. Can Gen Cytogenet 2009 188 : 65 9.
3. Kay NE, O'Brien SM, Pettitt AR, Stigenbauer S. The role of prognostic factors in assessing 'high risk' subgroups of patients with chronic lymphocytic leukemia. Leukemia 2007 21 : 1885 1891.
4. Zenz T, Mertens D, Döhner H, Stilgenbauer S. Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications. Leuk Lymphoma 2008 49 : 864 873.
5. Seiler T, Döhner H, Stilgenbauer S. Risk stratification in chronic lymphocytic leukemia. Semin Oncol 2006 33 : 186 194.
6. Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet 2008 371 : 1017 1029.
7. Moreno C, Montserrat E. New prognostic markers in chronic lymphocytic leukemia. Blood Rev 2008 22 : 211 219.
8. Deegan MJ, Abraham JP, Sawdyk M, Van Slyck EJ. High incidence of monoclonal proteins in the serum and urine of chronic lymphocytic leukemia patients. Blood 1984 64 : 1207 1211.
9. Martin W, Abraham R, Shanafelt T, Clark RJ, Bone N, Geyer SM, Katzmann JA, Bradwell A, Kay NE, Witzig TE. Serum free light chain - a new biomarker for patients with B cell non Hodgkin lymphoma and chronic lymphocytic leukemia. Transl Res 2007 149 : 231 235.
10. Pratt G, Harding S, Holder R, Fegan C, Pepper C, Oscier D, Gardiner A, Bradwell AR, Mead G. Abnormal serum free light chain ratios are associated with poor survival and may reflect biological subgroups in patients with chronic lymphocytic leukaemia. Br J Haematol 2009 144 : 217 222.
11. Kyrtsonis MC, Vassilakopoulos TP, Kafasi N, et al. Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. Br J Haematol 2007 137 : 240 243.
12. Rajkumar SV, Kyle RA, Therneau TM, Melton LJ III., Bradwell AR, Clark RJ, Larson DR, Plevak MF, Dispenzieri A, Katzmann JA. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 2005 106 : 812 817.
13. Dispenzieri A, Kyle RA, Katzmann JA, et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood 2008 111 : 785 789.
14. Dispenzieri A, Lacy MQ, Katzmann JA, et al. Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood 2006 107 : 3378 3383.
15. Dingli D, Kyle RA, Rajkumar SV, et al. Immunoglobulin free light chains and solitary plasmacytoma of bone. Blood 2006 108 : 1979 1983.
16. Drayson M, Tang LX, Drew R, Mead GP, Carr-Smith H, Bradwell AR. Serum free light chain measurements for identifying and monitorig patients with non secretory multiple myeloma. Blood 2001 97 : 2900 2902.
17. Pezzoli A, Pascali E. Monoclonal Bence Jones proteinuria in chronic lymphocytic leukaemia. Scand J Haematol 1986 36 : 18 24.
18. Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute - Working Group 1996 Guidelines. Blood 2008 111 : 5446 5456.
19. Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, Marce S, Guillermo AL, Campo E, Montserrat E. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Eng J Med 2003 348 : 1764 1775. (Pubitemid 36514707)
20. Perdigao J, Cabral MJ, Costa N, Carrao C, Costa P, Rodrigues T, Raposo J. Prognostic factors in CLL: is serum free light chain ratio a new biological marker? Ann Oncol 2008 19 (Suppl 4 410a.
21. Bockstaele FV, Verhasselt B, Philippe J. Prognostic markers in chronic lymphocytic leukemia: a comprehensive review. Blood Rev 2009 23 : 25 47.
22. Nenova I, Mateva N, Ananoshtev N, Grudeva-Popova J. The prognostic value of clinical and laboratory parameters in patients with chronic lymphocytic leukemia. Hematology 2005 10 : 47 51.
23. Zenz T, Döhner H, Stilgenbauer S. Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia. Best Pract Res Clin Haematol 2007 20 : 439 453.
24. Hamblin TJ. Prognostic markers in chronic lymphocytic leukaemia. Best Pract Res Clin Haematol 2007 20 : 455 468.
25. Hallek M. Prognostic factors in chronic lymphocytic leukemia. Ann Oncol 2008 19 (Suppl 4 51 3.