Efficacy of vitamin D3 supplementation in preventing fractures in elderly women: A meta-analysis

Current Medical Research and Opinion

Volumn 26, Issue 5, 2010, Pages 1193-1201

  Bergman, Gert J D ^a   Fan, Tao ^b   McFetridge, Jeffrey T ^c   Sen, Shuvayu S ^b  

^a MAPI GROUP   (Netherlands)

^b MERCK RESEARCH LABORATORIES   (United States)

^c LEHIGH UNIVERSITY   (United States)

Author keywords

Bone; Bone mineral density; Fracture; Osteoporosis; Postmenopausal; Women

Indexed keywords

CALCIUM; COLECALCIFEROL; PLACEBO;

ARTICLE; BAYES THEOREM; BONE DENSITY; CLINICAL TRIAL; DRUG EFFICACY; EMBASE; FRACTURE; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; MEDLINE; META ANALYSIS; POSTMENOPAUSE; SYSTEMATIC REVIEW; VITAMIN SUPPLEMENTATION; WRIST FRACTURE; AGED; DIET SUPPLEMENTATION; FEMALE;

AGED; BONE DENSITY; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; FEMALE; FRACTURES, BONE; HUMANS; PLACEBOS; POSTMENOPAUSE;

EID: 77951065146     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007991003659814     Document Type: Article

References (52)

1. Hodgson SF, Watts NB, Bilezikian JP, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the prevention and treatment of postmenopausal osteoporosis: 2001 edition, with selected updates for 2003. Endocr Pract 2003;9:544-564
2. Epstein S. Postmenopausal osteoporosis: fracture consequences and treatment efficacy vary by skeletal site. Aging (Milano) 2000;12:330-341
3. National Osteoporosis Foundation. Fast Facts on Osteoporosis. 2007 [cited 2010; Available from: http://www.nof.org/osteoporosis/diseasefacts.htm
4. US Department of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General. 2004 [cited 2010; Available from: http://www.surgeongeneral.gov/library/bonehealth/content.html
5. Melton 3rd LJ. Adverse outcomes of osteoporotic fractures in the general population. J Bone Miner Res 2003;18:1139-1141
6. Olsson C, Petersson C, Nordquist A. Increased mortality after fracture of the surgical neck of the humerus: a case-control study of 253 patients with a 12-year follow-up. Acta Orthop Scand 2003;74:714-717
7. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002;359:1761-1767
8. Orsini LS, Rousculp MD, Long SR, et al. Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures. Osteoporos Int 2005;16:359-371
9. Schneider EL, Guralnik JM. The aging of America. Impact on health care costs. JAMA 1990;263:2335-2340
10. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353-373
11. Malavolta N, Pratelli L, Frigato M, et al. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women. Osteoporos Int 2005;16:1691-1697
12. Beringer T, Heyburn G, Finch M, et al. Prevalence of vitamin D inadequacy in Belfast following fragility fracture. Curr Med Res Opin 2006;22:101-105
13. Dixon T, Mitchell P, Beringer T, et al. An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 2006;22: 405-415
14. Gallacher SJ, McQuillian C, Harkness M, et al. Prevalence of vitamin D inadequacy in Scottish adults with non-vertebral fragility fractures. Curr Med Res Opin 2005;21:1355-1361
15. Moniz C, Dew T, Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 2005;21:1891-1894
16. Ryan P, Dixon T. Prevalence of vitamin D inadequacy in patients attending a metabolic bone clinic in Medway. Curr Med Res Opin 2006;22:211-216
17. Simonelli C, Weiss TW, Morancey J, et al. Prevalence of vitamin D inadequacy in a minimal trauma fracture population. Curr Med Res Opin 2005; 21:1069-1074
18. Gaugris S, Heaney RP, Boonen S, et al. Vitamin D inadequacy among post-menopausal women: a systematic review. QJM 2005;98:667-676
19. Holick MF, Siris ES, Binkley N, et al. Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 2005;90:3215-3224
20. Bruyere O, Malaise O, Neuprez A, et al. Prevalence of vitamin D inadequacy in European postmenopausal women. Curr Med Res Opin 2007;23:1939-1944 (Pubitemid 47300393)
21. Moniz C, Dew T, Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 2005;21:1891-1894
22. Ness J, Aronow WS, Newkirk E, et al. Underutilization of calcium and vitamin D by older adults in a large general internal medicine practice. Am J Ther 2005;12:113-116
23. Hanley DA, Zhang Q, Meilleur MC, et al. Prescriptions for vitamin D among patients taking antiresorptive agents in Canada. Curr Med Res Opin 2007; 23:1473-1480
24. Bayly JR, Hollands RD, Riordan-Jones SE, et al. Prescribed vitamin D and calcium preparations in patients treated with bone remodelling agents in primary care: a report of a pilot study. Curr Med Res Opin 2006;22:131-137
25. Solomon DH, Morris C, Cheng H, et al. Medication use patterns for osteoporosis: an assessment of guidelines, treatment rates, and quality improvement interventions. Mayo Clin Proc 2005;80:194-202 (Pubitemid 40194534)
26. Tang BM, Eslick GD, Nowson C, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007; 370:657-666 (Pubitemid 47285316)
27. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257-2264 (Pubitemid 40629192)
28. Jackson C, Gaugris S, Sen SS, et al. The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 2007;100:185-192 (Pubitemid 47061686)
29. Boonen S, Lips P, Bouillon R, et al. Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007;92:1415-1423 (Pubitemid 46556419)
30. Leonard T, Duffy JC. A Bayesian fixed effects analysis of the Mantel-Haenszel model applied to meta-analysis. Stat Med 2002;21:2295-2312
31. Goodman SN. Toward evidence-based medical statistics. 2: The Bayes factor. Ann Intern Med 1999;130:1005-1013 (Pubitemid 29283992)
32. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (chole-calciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326:469 (Pubitemid 36269626)
33. Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005;365:1621-1628
34. Pfeifer M, Begerow B, Minne HW, et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 2000;15:1113-1118 (Pubitemid 30350073)
35. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992;327:1637-1642
36. Chapuy MC, Arlot ME, Delmas PD, et al. Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 1994; 308:1081-1082
37. Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 2002;13:257-264 (Pubitemid 34408194)
38. Porthouse J, Cockayne S, King C, et al. Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 2005;330:1003 (Pubitemid 40604285)
39. Dawson-Hughes B, Harris SS, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-676 (Pubitemid 27375473)
40. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009;169:551-561
41. Bischoff-Ferrari H, Shao A, Dawson-Hughes B, et al. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 2009 Dec 3. [Epub ahead of print]
42. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-683 (Pubitemid 43247138)
43. University of Wisconsin. Does treatment of hypovitaminosis D increase calcium absorption? In: ClinicalTrialsgov [Internet] Bethesda (MD): National Library of Medicine (US) 2000-[cited 2010 Jan 6] [cited NLM Identifier: NCT00581828; Available from: http://clinicaltrials.gov/ct2/show/NCT00581828
44. University of Wisconsin. Vitamin D Administration in the nursing home. In: ClinicalTrialsgov [Internet] Bethesda (MD): National Library of Medicine (US) 2000-[cited 2010 Jan 5] [cited; Available from: http://clinicaltrials.gov/ ct2/show/NCT00204919
45. Bischoff-Ferrari HA, Dawson-Hughes B. Where do we stand on vitamin D? Bone 2007;41:S13-19 (Pubitemid 46921513)
46. Agency for Healthcare and Research Quality. Effectiveness and safety of vitamin D in relation to bone health: US Department of Health and Human Services, 2007
47. Brown SE. Vitamin D and fracture reduction: an evaluation of the existing research. Altern Med Rev 2008;13:21-33
48. Mittlbock M, Heinzl H. A simulation study comparing properties of heterogeneity measures in meta-analyses. Stat Med 2006;25:4321-4333 (Pubitemid 46023775)
49. Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 2000;53:1119-1129
50. Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 1999;18:2693-2708
51. Resch H, Walliser J, Phillips S, et al. Physician and patient perceptions on the use of vitamin D and calcium in osteoporosis treatment: a European and Latin American perspective. Curr Med Res Opin 2007; 23:1227-1237 (Pubitemid 46998431)
52. Avenell A, Gillespie WJ, Gillespie LD, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev 2009: CD000227