Outbreak of carbapenem-resistant Klebsiella pneumoniae in Puerto Rico associated with a novel carbapenemase variant

Infection Control and Hospital Epidemiology

Volumn 31, Issue 5, 2010, Pages 476-484

  Gregory, Christopher J ^a,b   Llata, Eloisa ^a   Stine, Nicholas ^d   Gould, Carolyn ^a   Santiago, Luis Manuel ^b   Vazquez, Guillermo J ^c   Robledo, Iraida E ^c   Srinivasan, Arjun ^a   Goering, Richard V ^e   Tomashek, Kay M ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (Puerto Rico)

^c UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SURVEILLANCE; EPIDEMIC; FEMALE; GENE SEQUENCE; HUMAN; INFECTION CONTROL; KLEBSIELLA PNEUMONIAE INFECTION; MALE; PUERTO RICO; RISK FACTOR;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CASE-CONTROL STUDIES; DISEASE OUTBREAKS; DRUG RESISTANCE, BACTERIAL; FEMALE; GENETIC VARIATION; HOSPITALS, TEACHING; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PUERTO RICO; RISK FACTORS;

EID: 77951045230     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/651670     Document Type: Article

References (39)

1. Schwaber MJ, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA 2008;300:2911-2913.
2. Schwaber MJ, Klarfeld-Lidji S, Navon-Venezia S, Schwartz D, Leavitt A, Carmeli Y. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition onmortality. Antimicrob Agents Chemother 2008;52:1028-1033. (Pubitemid 351358384)
3. Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008; 29:1099-1106.
4. MacKenzie FM, Forbes KJ, Dorai-John T, Amyes SG, Gould IM. Emergence of a carbapenem-resistant Klebsiella pneumoniae. Lancet 1997;350: 783.
5. Bradford PA, Urban C, Mariano N, Projan SJ, Rahal JJ, Bush K. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC b-lactamase, and the foss of an outer membrane protein. Antimicrob Agents Chemother 1997;41: 563-569. (Pubitemid 27098404)
6. Deshpande LM, Jones RN, Fritsche TR, Sader HS. Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004). Microb Drug Resist 2006;12:223-230.
7. Srinivasan A, Patel JB. Klebsiella pneumoniae carbapenemase-producing organisms: an ounce of prevention really is worth a pound of cure. Infect Control Hosp Epidemiol 2008;29:1107-1109.
8. Bratu S, Landman D, Haag R, et al. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med 2005;165:1430-1435. (Pubitemid 40973427)
9. Bratu S, Mooty M, Nichani S, et al. Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection. Antimicrob Agents Chemother 2005;49:3018-3020. (Pubitemid 40917631)
10. Leavitt A, Navon-Venezia S, Chmelnitsky I, Schwaber MJ, Carmeli Y.Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother 2007;51:3026-3029. (Pubitemid 47206254)
11. Queenan AM, Bush K. Carbapenemases: the versatile b-lactamases. Clin Microbiol Rev 2007;20:440-458.
12. Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001;45:1151-1161. (Pubitemid 32230996)
13. Landman D, Bratu S, Kochar S, et al. Evolution of antimicrobial resistance among Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae in Brooklyn, NY. J Antimicrob Chemother 2007; 60:78-82. (Pubitemid 47073279)
14. Rice LB, Carias LL, Hutton RA, Rudin SD, Endimiani A, Bonomo RA. The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae. Antimicrob Agents Chemother 2008;52:3427-3429.
15. Garner JS, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections. In: Olmsted RN, ed. APIC Infection Control and Applied Epidemiology: Principles and Practice. St Louis, MO: Mosby; 1996: A1-A20.
16. Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: 19th information supplement. CLSI document. Wayne, PA: CLSI, 2009: M100-S19.
17. Moland ES, Black JA, Ourada J, Reisbig MD, Hanson ND, Thomson KS. Occurrence of newer b-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals. Antimicrob Agents Chemother 2002;46:3837-3842. (Pubitemid 35403258)
18. Goering RV. Pulsed-field gel electrophoresis. In: Persing DH, Tenover FC, Versalovic J, et al, eds. Microbiology: Diagnostic Principles and Practice. Washington, DC: ASM Press; 2004:185-196.
19. Siegel JD, Jackson M, Chiarello L; The Health Care Infection Control Practice Advisory Committee. 2007 Guidelines for isolation precautions: preventing transmission of infectious agents in health care settings. Centers for Disease Control and Prevention Web site. http://www.cdc.gov/ hicpac/2007IP/2007isolationPrecautions.html. Accessed July 27, 2009.
20. Larson EL. APIC guideline for handwashing and hand antisepsis in health care settings. Am J Infect Control 1995;23:251-269.
21. Ressner RA, Murray CK, Griffith ME, Rasnake MS, Hospenthal DR, Wolf SE. Outcomes of bacteremia in burn patients involved in combat operations overseas. J Am Coll Surg 2008;206:439-444.
22. Richards MJ, Edwards JR, Culver DH, Gaynes RP; National Nosocomial Infections Surveillance System. Nosocomial infections in pediatric intensive care units in the United States. Pediatrics 1999;103:e39. http:// pediatrics.aappublications.org/cgi/content/full/103/4/e39. Accessed July 27, 2009.
23. Aly NY, Al-Mousa HH, Al Asar el SM. Nosocomial infections in a medical-surgical intensive care unit. Med Princ Pract 2008;17:373-377.
24. Kwak YG, Choi SH, Choo EJ, et al. Risk factors for the acquisition of carbapenem-resistant Klebsiella pneumoniae among hospitalized patients. Microb Drug Resist 2005;11:165-169. (Pubitemid 40705827)
25. Falagas ME, Rafailidis PI, Kofteridis D, et al. Risk factors of carbapenemresistant Klebsiella pneumoniae infections: a matched case control study. J Antimicrob Chemother 2007;60:1124-1130. (Pubitemid 47617764)
26. Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicro bial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008;29:996-1011.
27. Navon-Venezia S, Leavitt A, Schwaber MJ, et al. First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States. Antimicrob Agents Chemother 2009;53:818-820.
28. Rasheed JK, Biddle JW, Anderson KF, et al. Detection of the Klebsiella pneumoniae carbapenemase type 2 carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid. J Clin Microbiol 2008;46:2066-2069.
29. Wolter DJ, Kurpiel PM, Woodford N, Palepou MF, Goering RV, Hanson ND. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. Antimicrob Agents Chemother 2009;53:557-562.
30. Wolter DJ, Khalaf N, Robledo IE, et al. Surveillance of carbapenemresistant Pseudomonas aeruginosa isolates from Puerto Rican medical center hospitals: dissemination of KPC and IMP-18 β-lactamases. Antimicrob Agents Chemother 2009;53(4):1660-1664.
31. Allman RM, Goode PS, Burst N, Bartolucci AA, Thomas DR. Pressure ulcers, hospital complications, and disease severity: impact on hospital costs and length of stay. Adv Wound Care 1999;12:22-30.
32. Hung EW, Darouiche RO, Trautner BW. Proteus bacteriuria is associated with significant morbidity in spinal cord injury. Spinal Cord 2007;45: 616-620. (Pubitemid 47373816)
33. Hussain R, Cevallos ME, Darouiche RO, Trautner BW. Gram-negative intravascular catheter-related bacteremia in patients with spinal cord injury. Arch Phys Med Rehabil 2008;89:339-342.
34. Lodise TP Jr, McKinnon PS, Rybak M. Prediction model to identify patients with Staphylococcus aureus bacteremia at risk for methicillin resistance. Infect Control Hosp Epidemiol 2003;24:655-661. (Pubitemid 37221336)
35. Roghmann MC, Siddiqui A, Plaisance K, Standiford H. MRSA colonization and the risk of MRSA bacteraemia in hospitalized patients with chronic ulcers. J Hosp Infect 2001;47:98-103. (Pubitemid 32181722)
36. Kanafani ZA, Mehio-Sibai A, Araj GF, Kanaan M, Kanj SS. Epidemiology and risk factors for extended-spectrum b-lactamase-producing organisms: a case control study at a tertiary care center in Lebanon. Am J Infect Control 2005;33:326-332. (Pubitemid 41074576)
37. Lin MF, Huang ML, Lai SH. Risk factors in the acquisition of extendedspectrum β-lactamase Klebsiella pneumoniae: a case-control study in a district teaching hospital in Taiwan. J Hosp Infect 2003;53:39-45.
38. Eveillard M, Quenon JL, Rufat P, Mangeol A, Fauvelle F. Association between hospital-acquired infections and patients' transfers. Infect Control Hosp Epidemiol 2001;22:693-696. (Pubitemid 34132009)
39. Centers for Disease Control and Prevention. Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. MMWR Morb Mortal Wkly Rep 2009;58(10):256-260.