Simplifying the complexity of cell signaling in medicine and the life sciences: Radicals and electrochemistry

Medical Hypotheses

Volumn 74, Issue 5, 2010, Pages 769-771

  Kovacic, Peter ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; AMINO ACID; AMPHOLYTE; ANION; CATION; LIGAND; METAL; PHOSPHATE; PROTEIN; RADICAL; RECEPTOR; SULFATE;

BINDING AFFINITY; BIOMEDICINE; CELL COMMUNICATION; EDITORIAL; ELECTROCHEMISTRY; ELECTRON TRANSPORT; MEDICINE; PHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN INTERACTION; STATIC ELECTRICITY;

CELL COMMUNICATION; IONS; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STATIC ELECTRICITY;

EID: 77951023689     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.10.032     Document Type: Editorial

References (22)

1. Kovacic P. Cell signaling (mechanism and reproductive toxicity): redox chains, radicals, electrons, relays, conduit, electrochemistry and other medical implications. Birth Defects Res Part C 2006, 78:333-344.
2. Hlavacek W.S., Faeder J.R. The complexity of cell signaling and the need for a new mechanics. Sci Signal 2009, 2. pe 46.
3. Shields J.M., Pruitt K., McFall A., Shaub A., Derr C.J. Understanding Ras: 'it ain't over' till it's over. Trends Cell Biol 2000, 10:147-154.
4. Kovacic P., Draskovich C.D., Pozos R.S. Unifying electrostatic mechanisms for phosphates and sulfates in cell signaling. J Recept Signal Transduct 2007, 27:433-443.
5. Kovacic P., Pozos R.S., Draskovich C.D. Unifying electrostatic mechanism for receptor-ligand activity. J Recept Signal Transduct 2007, 27:411-432.
6. Kovacic P. Unifying electrostatic mechanism for metal cations in receptors and cell signaling. J Recept Signal Transduct 2008, 28:153-162.
7. Kovacic P. Bioelectrostatics: review of widespread importance in biochemistry. J Electrostat 2008, 66:124-129.
8. Kovacic P., Pozos R.S. Bioelectronome. Integrated approach to receptor chemistry, radicals, electrochemistry, cell signaling and physiological effects based on electron transfer. J Recept Signal Transduct 2007, 27:261-294.
9. Oxidative stress and signal transduction 1997, 475. Springer, New York. H.G. Forman, E. Cadenas (Eds.).
10. Hancock G.T. Cell signaling 2005, Oxford University Press, New York, p. 296.
11. Kovacic P. Protein electron transfer (mechanism and reproductive toxicity): iminium, hydrogen bonding, homoconjugation, amino acid side chains (redox and charged), and cell signaling. Birth Defects Res Part C 2007, 81:51-64.
12. Cevc G. Membrane electrostatics. Biochim Biophys Acta 1990, 1031-3:311-382.
13. Campbell N.A. Biology 1993, Benjamin/Cummings, New York, p. 99.
14. Dong J., Ye P., Schade A.G., Gao S., Romo G.M., Turner T., et al. Tyrosine sulfation of glycoprotein 1 (b) alpha. Role of electrostatic interaction in von Willebrand factor binding. J Biol Chem 2001, 276:16690-16694.
15. Duisit G., Saleun S., Douthe S., Barsoum J., Chadeuf G., Moullier P. Baculovirus vector requires electrostatic interactions including heparin sulfate for efficient gene transfer in mammalian cells. J Gene Med 1999, 1:93-102.
16. Gomperte B.D., Tathem P.E.R., Kramer I.M. Signal transduction 2002, vol. 25. Academic Press, New York, p. 173-82.
17. Ishikita H., Knapp E.W. Electrostatic role of photosynthetic reaction center. FEBS Lett 2006, 580:4567-4570.
18. Raines D.E., Claycomb R.J., Forman S.A. Modulation of GABA (A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition. Anesth Analg 2003, 96:112-118.
19. Birtwistle M.R., Hatakeyama M., Yumoto N., Ogunnaike B.A., Hoek J.B., Kholodenko B.N. Ligand-dependent responses of the ErbB signaling network: experimental and modeling analysis. Mol Syst Biol 2007, 3:144.
20. Natarajan M., Lin K.M., Hsueh R.C., Sternweis P.C., Ranganathan R. A global analysis of cross-talk in mammalian cellular signaling network. Nat Cell Biol 2006, 8:571-580.
21. Kovacic P., Somanathan R. Ototoxicity and noise trauma: electron transfer, reactive oxygen species, cell signaling, electrical effects, and protection by antioxidants. Med Hypotheses 2008, 70:914-923.
22. Kovacic P. Unifying mechanism for addiction and toxicity of abused drugs with application to dopamine and glutamate mediators: electron transfer and reactive oxygen species. Med Hypotheses 2005, 65:90-96.