A method for identifying small molecule aggregators using photonic crystal biosensor microplates

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Volumn , Issue , 2009, Pages 788-791

  Chan, Leo L ^a   Lidstone, Erich A ^a   Finch, Kristin E ^b   Heeres, James T ^c   Hergenrother, Paul J ^b,c   Cunningham, Brian T ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; ASSAYS; BIOSENSORS; DIAGNOSIS; DYNAMIC LIGHT SCATTERING; LIGHT SCATTERING; MATERIALS HANDLING; MOLECULES; PHOTONIC CRYSTALS; SCANNING ELECTRON MICROSCOPY; THROUGHPUT;

ALPHA CHYMOTRYPSINS; AUTOMATED LIQUID HANDLING; COLORIMETRIC ASSAYS; HIGH-THROUGHPUT SCREENS; LABEL-FREE DETECTION METHOD; OPTICAL BIO-SENSORS; PHARMACEUTICAL DISCOVERY; PHOTONIC CRYSTAL BIOSENSORS;

BIOASSAY;

EID: 77951021548     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2009.5333796     Document Type: Conference Paper

References (9)

1. A. J. Ryan, N. M. Gray, P. N. Lowe, and C.-w. Chung, "Effect of Detergent on "Promiscuous" Inhibitors," J. Med. Chem., vol.46, pp. 3448-3451, 2003.
2. A. M. Giannetti, B. D. Koch, and M. F. Browner, "Surface Plasmon Resonance Based Assay for the Detection and Characterization of Promiscuous Inhibitors," J. Med. Chem., vol.51, pp. 574-580, 2008.
3. S. L. McGovern and B. K. Shoichet, "Kinase Inhibitors: Not Just for Kinases anymore," J. Med. Chem., vol.46, pp. 1478-1483, 2003.
4. G. M. Keseru and G. M. Makara, "Hit discovery and hit-to-lead approaches," Drug Discovery Today, vol.11, pp. 741-748, 2006.
5. D. R. Goode, R. K. Totten, J. T. Heeres, and P. J. Hergenrother, "Identification of promiscuous small molecule activators in high-throughput enzyme activation screens," J Med Chem, vol.51, pp. 2346-2349, 2008.
6. I. S. I. 13321, "Methods for Determination of Particle Size Distribution Part 8: Photon Correlation Spectroscopy," 1996.
7. C. M. T. Kaszuba M., McNeil-Watson F.K., "Resolving concentrated particle size mixtures using dynamic light scattering," Particle & Particle Systems Characterization, vol.24, pp. 159-162, 2007.
8. B. T. Cunningham, P. Li, S. Schulz, B. Lin, C. Baird, J. Gerstenmaier, C. Genick, F. Wang, E. Fine, and L. Laing, "Label-Free Assays on the BIND System," Journal of Biomolecular Screening, vol.9, pp. 481-490, 2004.
9. B. Lin, P. Li, and B. T. Cunningham, "A label-free biosensor-based cell attachment assay for characterization of cell surface molecules," Sensors and Actuators B-Chemical, vol.114, pp. 559-564, 2006.