Upstream mechanotaxis behavior of endothelial cells

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Volumn , Issue , 2009, Pages 2106-2110

  Song, Sukhyun ^a   Kim, Mina ^a   Shin, Jennifer H ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; CELLS; CYTOLOGY; SHEAR FLOW; SHEAR STRESS; STIFFNESS;

ENDOTHELIAL CELL REMODELING; ENDOTHELIALIZATION; HEMODYNAMIC FORCES; SHEAR STRESS MAGNITUDES; SUBSTRATE STIFFNESS; UPSTREAM MIGRATION; VASCULAR ENDOTHELIAL CELLS; VASCULAR REMODELING;

ENDOTHELIAL CELLS;

EID: 77951021507     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2009.5334307     Document Type: Conference Paper

References (18)

1. T. Ohashi and M. Sato, "Remodeling of vascular endothelial cells exposed to fluid shear stress: Experimental and numerical approach," Fluid Dyn. Res. 37 (1-2) pp. 40-59, 2005
2. S. Chien, "Molecular and mechanical bases of focal lipid accumulation in arterial wall," Prog. Biophys. Mol. Biol. 83 (2) pp. 131-151, 2003
3. A. J. Ridley, M. A. Schwartz, K. Burridge, R. A. Firtel, M. H. Ginsberg, G. Borisy, J. T. Parsons and A. R. Horwitz, "Cell migration: Integrating signals from front to back," Science. 302 (5651) pp. 1704-1709, 2003
4. D. A. Lauffenburger and A. F. Horwitz, "Cell migration: A physically integrated molecular process," Cell. 84 (3) pp. 359-369, 1996
5. M. P. Sheetz, D. Felsenfeld, C. G. Galbraith and D. Choquet, "Cell migration as a five-step cycle," Biochem. Soc. Symp. (65) pp. 233-243, 1999
6. S. Li, P. Butler, Y. X. Wang, Y. L. Hu, D. C. Han, S. Usami, J. L. Guan and S. Chien, "The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells," Proc. Natl. Acad. Sci. U.S.A. 99 (6) pp. 3546-3551, 2002
7. P. P. Hsu, S. Li, Y. S. Li, S. Usami, A. Ratcliffe, X. Wang and S. Chien, "Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation," Biochem. Biophys. Res. Commun. 285 (3) pp. 751-759, 2001
8. M. Masuda and K. Fujiwara, "The biased lamellipodium development and microtubule-organizing center position in vascular endothelial-cells migrating under the influence of fluid-flow," Biol. Cell. 77 (3) pp. 237-245, 1993
9. X. Q. Brown, K. Ookawa, and J. Y. Wong, "Evaluation of polydimethylsiloxane scaffolds with physiologically-relevant elastic moduli: interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response," Biomaterials 26 (16) pp. 3123-3129, 2005.
10. Laurent, X. Girerd, J. J. Mourad, P. Lacolley, L. Beck, P. Boutouyrie, J. P. Mignot and M. Safar, "Elastic modulus of the radial artery wall material is not increased in patients with essential hypertension," Arterioscler. Thromb. Vasc. Biol. 14 (7) pp. 1223-1231, 1994
11. S. Song, M. Kim, and J. H. Shin "Shear stress system for quantitative analysis of long-term cellular dynamic responses," ASME, J. Biomech. Eng., submitted for publication.
12. X. F. Lin and B. P. Helmke, "Micropatterned structural control suppresses mechanotaxis of endothelial cells," Biophys. J. 95 (6) pp. 3066-3078, 2008 S.
13. S. Song and J.H. Shin, "Dynamic behavior of bEnd.3," unpublished.
14. P. F. Davies, A. Robotewskyj and M. L. Griem, "Quantitative studies of endothelial-cell adhesion - directional remodeling of focal adhesion sites in response to flow forces," J. Clin. Invest. 93 (5) pp. 2031-2038, 1994
15. P. P. Hsu, S. Li, Y. S. Li, S. Usami, A. Ratcliffe, X. Wang and S. Chien, "Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation," Biochem. Biophys. Res. Commun. 285 (3) pp. 751-759, 2001
16. Y. L. Hu, S. Li, H. Miao, T. C. Tsou, M. A. del Pozo and S. Chien, "Roles of microtubule dynamics and small gtpase rac in endothelial cell migration and lamellipodium formation under flow," J. Vasc. Res. 39 (6) pp. 465-476, 2002
17. S. Li, N. F. Huang and S. Hsu, "Mechanotransduction in endothelial cell migration," J. Cell. Biochem. 96 (6) pp. 1110-1126, 2005
18. M. O. Parat, B. Anand-Apte and P. L. Fox, "Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions," Mol. Biol. Cell. 14 (8) pp. 3156-3168, 2003