Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice

Circulation Research

Volumn 106, Issue 6, 2010, Pages 1052-1060

  Tomita, Hirofumi ^a   Zhilicheva, Svetlana ^a   Kim, Shinja ^a   Maeda, Nobuyo ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Apolipoprotein E null mice; Atherosclerosis; Quantitative trait locus; Vascular geometry

Indexed keywords

APOLIPOPROTEIN E;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ARCH; AORTA ROOT; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHROMOSOME 1; CHROMOSOME 15; CHROMOSOME 9; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC TRAIT; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHROMOSOMES, MAMMALIAN; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RISK FACTORS; SPECIES SPECIFICITY;

EID: 77951021431     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.207175     Document Type: Article

References (22)

1. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999;282:2035-2042.
2. Friedman MH, Deters OJ, Mark FF, Bargeron CB, Hutchins GM. Arterial geometry affects hemodynamics. A potential risk factor for ather-soclerosis. Atherosclerosis. 1983;46:225-231.
3. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hyper-cholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
4. Maeda N, Johnson L, Kim S, Hagaman J, Friedman M, Reddick R. Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds. Atherosclerosis. 2007;195:75-82.
5. Zhu H, Zhang J, Shih J, Lopez-Bertoni F, Hagaman JR, Maeda N, Friedman MH. Differences in aortic arch geometry, hemodynamics, and plaque patterns between C57BL/6 and 129/SvEv mice. J Biomechanical Eng. 2009;131:121005.
6. Chen Y, Rollins J, Paigen B, Wang X. Genetic and genomic insights into the molecular basis of atherosclerosis. Cell Metab. 2007;6:164-179.
7. Dansky HM, Shu P, Donavan M, Montagno J, Nagle DL, Smutko JS, Roy N, Whiteing S, Barrios J, McBride TJ, Smith JD, Duyk G, Breslow JL, Moore KJ. A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse. Genetics. 2002;160:1599-1608.
8. Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvImJ. Arterioscler Thromb Vasc Biol. 2004;24:161-166.
9. Teupser D, Tan M, Persky AD, Breslow JL. Atherosclerosis quantitative trait loci are sex-and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/-mice. Proc Natl Acad Sci USA. 2006;103:123-128.
10. Smith JD, Bhasin JM, Baglione J, Settle M, Xu Y, Barnard J. Atherosclerosis susceptibility loci identified from a strain intercross of apoli-poprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006;26:597-603.
11. Wang SS, Shi W, Wang X, Velky L, Greenlee S, Wang MT, Drake TA, Lusis AJ. Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice. Arterioscler Thromb Vasc Biol. 2007;27:2671-2676.
12. Paigen B, Mitchell D, Reue K, Morrow A, Lusis AJ, LeBoeuf RC. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci USA. 1987;84: 3763-3767. (Pubitemid 17088360)
13. Phelan SA, Beier DR, Higgins DC, Paigen B. Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on chromosome 1. Mamm Genome. 2002;13:548-553.
14. Wang X, Ria M, Kelmenson PM, Eriksson P, Higgins DC, Samnegard A, Petros C, Rollins J, Bennet AM, Wiman B, de Faire U, Wennberg C
15. Olsson PG, Ishii N, Sugamura K, Hamsten A, Forsman-Semb K, Lager-crantz J, Paigen B. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet. 2005;37:365-372.
16. Su Z, Li Y, James JC, McDuffie M, Matsumoto AH, Helm GA, Weber JL, Lusis AJ, Shi W. Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene. Genetics. 2006;172:1799-1807.
17. Teupser D, Pavlides S, Tan M, Gutierrez-Ramos JC, Kolbeck R, Breslow JL. Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci USA. 2004;101:17795-17800.
18. Bonthu S, Heistad DD, Chappell DA, Lamping KG, Faraci FM. Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 1997;17:2333-2340.
19. Burgess-Herbert SL, Cox A, Tsaih SW, Paigen B. Practical applications of the bioinformatics toolbox for narrowing quantitative trait loci. Genetics. 2008;180:2227-2235.
20. Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol. 2007;27:1248-1258.
21. Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. Fate of the mammalian cardiac neural crest. Development. 2000;127:1607-1616.
22. Waldo KL, Hutson MR, Ward CC, Zdanowicz M, Stadt HA, Kumiski D, Abu-Issa R, Kirby ML. Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. Dev Biol. 2005;281:78-90 (Pubitemid 40558724)