Engineering analysis and development of the spheroid reservoir bioartificial liver

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Volumn , Issue , 2009, Pages 5985-5988

  McIntosh, Malcolm B ^a   Corner, Stephen M ^a   Amiot, Bruce P ^b   Nyberg, Scott L ^a  

^a MAYO CLINIC   (United States)

^b Brami Biomedical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENGINEERING; INDUSTRIAL ENGINEERING;

ACTIVE COMPONENTS; ACUTE LIVER FAILURE; BIOARTIFICIAL LIVER; DESIGN AND DEVELOPMENT; ENGINEERING ANALYSIS; HIGH CELL DENSITY; PRODUCTION REQUIREMENTS; SUPPORT DEVICES;

ARTIFICIAL ORGANS;

EID: 77951016566     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2009.5334687     Document Type: Conference Paper

References (8)

1. W. Kim, R. Brown, N. Terrault, and H. El-Serag, "Burden of liver disease in the United States: Summary of a workshop," Hepatology, vol.36, pp. 227-242, July 2002.
2. M. L. Yarmush, J. C. Dunn, and R. G. Tompkins, "Assessment of artificial liver support technology," Cell Transplantation, vol.1, pp. 323-341, Feb. 1992.
3. I. M. Sauer, D. Kardassis, K. Zeillinger, A. Pascher, A. Gruenwald, G. Pless, M. Irgang, M. Kraemer, G. Puhl, J. Frank, A. R. Müller, T. Steinmüller, J. Denner, P. Neuhaus, and J. C. Gerlach, "Clinical extracorporeal hybrid liver support - phase I study with primary porcine liver cells," Xenotransplantation, vol.10, pp 460-469, Sept 2003.
4. M. S. Margulis, E. A. Erukhimov, L. A. Andreiman, and L. M. Viksna, "Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency," Resuscitation, vol.18, pp. 85-94, Oct 1989.
5. T. McKenzie, J. Lillegard, and S. Nyberg, "Artificial and bioartificial liver support," Seminars In Liver Disease, vol.28, pp. 210-217, May 2008.
6. S. Nyberg, J. Hardin, B. Amiot, U. Argikar, R. P. Remmel, and P. Rinaldo, "Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver," Liver Transplantation, vol.11, pp. 901-910, Aug. 2005.
7. C. Brophy, J. Luebke-Wheeler, B. Amiot, H. Khan, R. Remmel, P. Rinaldo, and S. Nyberg, "Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function," Hepatology, vol.49, pp. 578-586, Feb. 2009.
8. A. Lazar, M. V. Peshwa, F. J. Wu, C. M. Chi, F. B. Cerra, and W. S. Hu, "Formation of porcine hepatocyte spheroids for use in a bioartificial liver," Cell Transplantation, vol.4, pp. 259-268, May-June 1995.