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The concept 'permanent' is not easy to define. We can avoid some confusion though if we distinguish between a metaphysical and an epistemic understanding of this term. Metaphysically, permanent organismic discontinuity for an organism occurs when in fact the organism will forever not be able to coordinate its life processes. Epistemically though, we can of course be wrong about when this point has occurred for an organism. For a further discussion of this concept, see Lawrence C. Becker, 'Human Being: The Boundaries of the Concept', Philosophy and Public Affairs 4:4 (1975): 334-359
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van Inwagen's example is a group of cheerleaders coordinating to form a pyramid (Material Beings, op. cit60. )
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Material Beings
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Blastomeres Arising from the First Cleavage Division Have Distinguishable Fates in Normal Mouse Development
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Cdx2 Gene Expression and Trophectoderm Lineage Specification in Mouse Embryos
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For a defense of this as the starting point of our existence, see, e.g., Damschen, Gomez-Lobo, and Schoenecker, 'Sixteen Days?,' 132, no. 3 (op. cit479-90
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The Brain and Somatic Integration: Insights into the Standard Biological Rationale for Equating Brain Death with Death
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