The design of efficient and selective routes to a key 1,4-cis-substituted cyclohexylamide intermediate

Tetrahedron Letters

Volumn 51, Issue 21, 2010, Pages 2846-2848

  Barfoot, Christopher ^a   Brooks, Gerald ^a   Davies, David T ^a   Elder, John ^a   Giordano, Ilaria ^a   Hennessy, Alan ^a   Jones, Graham ^a   Markwell, Roger ^a   McGuire, Michael ^b   Miles, Timothy ^a   Pearson, Neil ^b   Spoors, Grant ^b   Sudini, Ravinder ^b   Wei, Hengxu ^b   Wood, Jeffery ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CYCLOHEXYLAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CIS TRANS ISOMERISM; PROCESS OPTIMIZATION; PURIFICATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 77950929701     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.03.083     Document Type: Article

References (11)

1. Full name for 1: 1,1-dimethylethyl[cis-4-(aminocarbonyl)-4-hydroxycyclohexyl]carbamate. For the syntheses of these compounds and experimental details for the reactions in Schemes 1 and 2, see: (a) Brooks, G.; Davies, D. T.; Jones, G. E.; Markwell, R. E.; Pearson, N. D.; WO 2003087098; Chem. Abstr.; 2003, 139, 337959; (b) Axten, J. M.; Daines, R. A.; Davies, D. T.; Gallagher, T. F.; Jones, G. E.; Miller, W. H.; Pearson, N. D.; Pendrak, I.; WO 2004002992; Chem. Abstr.; 2004, 140, 94053.
2. For a synthesis, see: Ref. 1(b), example 3(a).
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11. +.